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Breast Cancer: early-phase trial registry
423 of 1,251 indexed Breast Cancer trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #1 of 28,707 conditions by registered trial count.
1,251 US clinical trials · 423 currently recruiting · #1 of 28,707 conditions by registered trial count
Breast Cancer: 1,251 US clinical trials tracked, 423 recruiting.
Breast Cancer is the subject of 1,251 registered US clinical trials on ClinicalTrials.gov, 423 of them currently open to new participants. 120 are in Phase 3-4 (later-stage) and 491 in Phase 1-2 (earlier-stage). The most active sponsor is Memorial Sloan Kettering Cancer Center, running 98 of these trials.
Enrollment posture brief
Registry condition breast-cancer
OPEN 423 | RECR 34% | LATE 120 | EARLY 491 | RANK #1 | SPON 98
Volume-matched condition peers
Nearest open-share peer: Refractory Multiple Myeloma (34% recruiting · 68 trials)
Breast Cancer lists 423 open slots (34% of 1,251 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Breast Cancer on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Breast Cancer is recruiting below its size-band peers.
423 of 1,251 indexed trials (33.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Breast Cancer trials is spread across many organizations.
Memorial Sloan Kettering Cancer Center accounts for 98 of 1,251 trials (7.8%). 367 distinct sponsors appear on at least one study for this condition label.
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Typical Breast Cancer enrolment sits around 90 participants.
Median target enrolment is 90 among the 1,225 trials that report a genuine target (sentinel values excluded). 630 of those (51.4%) plan for fewer than 100 participants.
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Breast Cancer research is mostly interventional.
1,015 interventional and 236 observational studies make up this index (81.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
1,251 total, page 8 of 26
A Study of Radiation Therapy With Pembrolizumab and Olaparib or Other Radiosensitizers in Women Who Have Triple-Negative or Hormone-Receptor Positive/Her2 Negative Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT04683679
Guided Meditation During Radiation Therapy for Breast and Gynecological Malignancies
University of Utah
NCT07166042
Study to Evaluate the Feasibility of Twice Daily Use of Topical Azelaic Acid in Breast Cancer Patients Undergoing Radiation
Virginia Commonwealth University
NCT06966388
Focused Ultrasound and Gemcitabine in Breast Cancer
Patrick Dillon, MD
NCT04796220
Reiki Breast Surgery QOL Project for Women Undergoing Breast Surgery
Albert Einstein College of Medicine
NCT06524895
Sacituzumab Govitecan and Zimberelimab w/SRS in the Management of Metastatic Triple Negative Breast Cancer With Brain Metastases
H. Lee Moffitt Cancer Center and Research Institute
NCT06238921
Surviving Daily Life
Thomas Jefferson University
NCT07054723
Evaluation of Talazoparib, a PARP Inhibitor, in Patients With Somatic BRCA Mutant Metastatic Breast Cancer: Genotyping Based Clinical Trial
Massachusetts General Hospital
NCT03990896
KK-LC-1 TCR-T Cell Therapy for Gastric, Breast, Cervical, and Lung Cancer
Christian Hinrichs
NCT05483491
Dance Study for Post-surgical Pain in Breast Cancer Survivors
Dana-Farber Cancer Institute
NCT06758102
Study of Ribociclib Administered Concurrently With Postoperative Radiation Therapy in Patients With High-Risk, HR+/HER2- Breast Cancer
University of Michigan Rogel Cancer Center
NCT05996107
Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers
Ruth O'Regan
NCT04886531
TNBC Gut Microbiota During Neoadjuvant Treatment
Scripps Health
NCT06610097
A Study Evaluating the Feasibility and Compliance of Manual Lymphatic Drainage Comparing Indocyanine-Green (ICG) Guided vs. Traditional Guided in Patients Undergoing Axillary Node Dissection for the Treatment of Breast Cancer
University of Florida
NCT06327490
Gut Microbiome, Adverse Effects, and Markers Through MEtabolic Reprogramming
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
NCT06536881
Definitive Radiation Therapy for Inoperable Breast Cancer
Alexander Stessin
NCT07122713
Pioglitazone Therapy Targeting Fatigue in Breast Cancer
West Virginia University
NCT05013255
Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy
Dana-Farber Cancer Institute
NCT04724499
Near Infrared Spectroscopy (NIRS) as a Method for Measuring Oxidative Capacity of Skeletal Muscle Mitochondria in Breast Cancer and All Gynecological Cancer Patients
University of South Carolina
NCT06672497
Resistance Training and Post Workout Protein to Improve Body Composition During Neoadjuvant Chemotherapy for Breast Cancer
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT06858449
A Study of Pembrolizumab and Cryoablation in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06246968
Tucatinib+Trastuzumab+Eribulin in HER2+ MBC
Criterium
NCT05458674
A Study Comparing Cancer Imaging Approaches in People With Lobular Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06557148
Everyday Exposures: How Chemicals and Weight Impact Breast Cancer Risk
M.D. Anderson Cancer Center
NCT07137468
Tart Cherry and Omega-3's for Aromatase Inhibitor Musculoskeletal Symptoms
Philip Chang
NCT06123286
CDK and Body Composition Study
Montefiore Medical Center
NCT03697577
Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer
University of Wisconsin, Madison
NCT03936478
Piloting Y-AMBIENT: A Quality of Life Intervention for Young African American Breast Cancer Survivors
University of Alabama at Birmingham
NCT05452681
Neoadjuvant Therapy and Contrast-enhanced Mammography for Early Stage Breast Cancer
Alison Stopeck
NCT06220214
EXERT-BCH Exercise Regimen to Improve Muscle Mass After Treatment of Breast Cancer
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
NCT06115486
A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT06678269
BRE-10: Biomarker Optimization of Neoadjuvant Therapy in Breast Cancer
University of Illinois at Chicago
NCT06441890
A Study of MT-4561 in Patients With Various Advanced Solid Tumors
Tanabe Pharma America
NCT06943521
Real World Treatment Experience of Patients With Breast, Lung, Ovarian, Multiple Myeloma, or Acute Myelogenous Leukemia Using Remote Symptom Monitoring
Carevive Systems
NCT05974150
Oral Aromatase Inhibitors Modify the Gut Microbiome
Wake Forest University Health Sciences
NCT05030038
BRE-08 Phase II Study of CMC Regimen for Early Stage Breast Cancer
University of Illinois at Chicago
NCT06085742
A Phase Ib Study of Novel Combination (New) of Low Dose Oral CyclophoSphamide (s) to Potentiate Axatilimab (A) + Retifanlimab (R) in Treating Metastatic Triple Negative Breast Cancer (TNBC)
M.D. Anderson Cancer Center
NCT06959537
Exercise to ReGain Stamina and Energy (The EXERGISE Study)
University of Florida
NCT05684367
Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial
University of California, Irvine
NCT07447050
Perioperative Mindfulness Proposal
Hoag Memorial Hospital Presbyterian
NCT04049214
F-Tryptophan PET/CT in Human Cancers
Barbara Ann Karmanos Cancer Institute
NCT05556473
Pharmacokinetic Study of Skeletal Muscle Area-based Paclitaxel Infusion in Patients With Cancer
University of Michigan Rogel Cancer Center
NCT05183126
Trial of Neratinib Plus Capecitabine in Subjects With HER2-Negative Metastatic Breast Cancer With Brain Metastases and Abnormally Active HER2 Signaling
University of Rochester
NCT04965064
Preoperative Irradiation for Stage I Breast Cancer
Parul Barry
NCT05464667
Brain [18F]-FES PET/CT in Patients With Estrogen-Receptor Positive Breast Cancer
Weill Medical College of Cornell University
NCT06072807
A Phase 2 Single-Arm Open-Label Pilot Trial Evaluating Zanidatamab (ZW25) in Patients With Early Stage HER2/Neu Positive (HER2+) Breast Cancer (BC)
M.D. Anderson Cancer Center
NCT05035836
24GUT540 : Meeting of Breast Cancer Patients and Pathologists
Dartmouth-Hitchcock Medical Center
NCT07040514
MRg-NIRS Imaging System Breast Cancer Trial
Keith D. Paulsen
NCT06400563
Neratinib in Combination With Ruxolitinib in Patients With mTNBC
Baylor Research Institute
NCT06008275
A Study of a One-Time Counseling Session to Help Reduce Depression, Anxiety, and Distress in People With Breast Cancer
Memorial Sloan Kettering Cancer Center
NCT07218250
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 235 |
| Phase 2 | 256 |
| Phase 3 | 100 |
| Phase 4 | 20 |
Top Sponsors
Named interventions
Most-linked intervention names on Breast Cancer records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Breast Cancer trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Breast Cancer page
1,251 registered trials, 423 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 423 Breast Cancer trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Memorial Sloan Kettering Cancer Center sponsors the most Breast Cancer trials on record, review their full trial history before evaluating a specific study. See Memorial Sloan Kettering Cancer Center's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Breast Cancer condition card totals 1,251 registered trials; most-linked intervention Fulvestrant; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.