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NCT05464667 · ClinicalTrials.gov registry record · NA
Preoperative Irradiation for Stage I Breast Cancer
A NA study of Breast Cancer, sponsored by Parul Barry.
- Recruiting
- Registry status
- NA
- Development phase
- 21
- Enrollment target
- 1
- Study location
NCT05464667: Recruiting NA study of Breast Cancer, sponsored by Parul Barry.
NCT05464667 is a NA study of Breast Cancer that is actively recruiting participants, run by Parul Barry. The registered enrollment target is 21 participants, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05464667, a NA study of Breast Cancer, is actively recruiting participants, sponsored by Parul Barry.
- RECRUITING
- Registry status
- NA
- Development phase
- 21 participants
- Enrollment target
- 1
- Study location
Study Summary
The novel use of preoperative RT will have broad implications for breast cancer patients, most of whom present with early-stage disease. In the era of reduced chemotherapy delivery, preoperative RT will allow oncologists to assess radiologic and biologic tumor response and correlate it to outcomes. Underutilization of RT negatively affects mortality. This trial aims to further evaluate pre-operative radiation therapy in patients with early stage, biologically favorable breast cancer, with improved access to RT.
Primary Outcome
Maximum tolerated dose (MTD) of RT, which will be defined based on the occurrence of grade 2 or higher acute radiation dermatitis as defined per National Cancer Institute, Common Terminology Criteria for Adverse Events (CTCAE) v5.0, occurring within approximately 1 month after radiation therapy (RT). Dose escalation will begin with 30 GY and be escalated to 35, 40, and 50 GY as tolerated.
Conditions Studied
Interventions
- RADIATION Radiation Therapy (RT)
Study Locations (1)
Pennsylvania
- UPMC Magee Womens Hospital - Radiation Oncology - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 21 participants |
| Start Date | 2023-07-07 |
| Est. Completion | 2028-03-31 |
| Phase | NA |
What NCT05464667 shows while recruiting
NCT05464667 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 21 participants, a relatively small participant target, below the 2,803-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (99% lower).
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 1 intervention - of which Radiation Therapy (RT) is the first listed.
NCT05464667 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT05464667 about?
NCT05464667 is a clinical study titled "Preoperative Irradiation for Stage I Breast Cancer". The novel use of preoperative RT will have broad implications for breast cancer patients, most of whom present with early-stage disease. In the era of reduced chemotherapy delivery, preoperative RT will allow oncologists to assess radiologic and biologic tumor response and correlate it to outcomes. ...
What is the current status of trial NCT05464667?
This trial is currently recruiting. It is a NA study. The enrollment target is 21 participants. The study started on 2023-07-07. Estimated completion is 2028-03-31.
What conditions does trial NCT05464667 study?
This clinical trial studies the following conditions: Breast Cancer.
What interventions are being tested in trial NCT05464667?
The interventions under investigation include: Radiation Therapy (RT) (RADIATION).
Who is sponsoring clinical trial NCT05464667?
This trial is sponsored by Parul Barry, which has 2 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05464667 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05464667's enrollment target sits among peer trials
21 1073rd of 1224 higher than 147 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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