Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT04827238 · ClinicalTrials.gov registry record
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
A clinical trial of Aortic Valve Stenosis and Aortic Stenosis, sponsored by University of British Columbia.
- Completed
- Registry status
- 49
- Enrollment target
- 9
- Study locations
NCT04827238: Completed study of Aortic Valve Stenosis and Aortic Stenosis, sponsored by University of British Columbia.
NCT04827238 is a study of Aortic Valve Stenosis and Aortic Stenosis that has completed, run by University of British Columbia. The registered enrollment target is 49 participants, below the 1,042-participant average among 30 other Aortic Valve Stenosis trials with a reported enrollment target (95% lower). The trial reports 9 study locations across 7 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04827238, a study of Aortic Valve Stenosis and Aortic Stenosis, has completed, sponsored by University of British Columbia.
- COMPLETED
- Registry status
- 49 participants
- Enrollment target
- 9
- Study locations
Study Summary
The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
Primary Outcome
Transaortic valve gradients measured by echocardiography and direct invasive methods
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Standardized Invasive Hemodynamics
Study Locations (9)
Indiana
- eCommunity - Indianapolis
- Community Hospital - Munster
British Columbia
- Vancouver General Hospital - Vancouver
- St. Paul's Hospital - Vancouver
Arizona
- PIMA Heart Centre - Tucson
Florida
- Tenet Health - Boca Raton
Massachusetts
- Massachusetts General Hospital - Boston
Michigan
- William Beaumont Hospital - Southfield
Ontario
- McMaster University - Hamilton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 49 participants |
| Start Date | 2021-08-30 |
| Est. Completion | 2025-06-20 |
What the finished NCT04827238 record still lists
NCT04827238 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 49 participants, a relatively small participant target, below the 1,042-participant average among 30 other Aortic Valve Stenosis trials with a reported enrollment target (95% lower).
The record links to 2 conditions, with Aortic Valve Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Standardized Invasive Hemodynamics is the first listed.
NCT04827238 lists 9 locations in 7 states (Indiana, British Columbia, Arizona).
Frequently Asked Questions
What is clinical trial NCT04827238 about?
NCT04827238 is a clinical study titled "Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)". The DISCORDANCE TAVR study will determine the discordance between echocardiography-derived and invasive transaortic gradients, as determined by a consistent and reproducible technique (Standardized Invasive Hemodynamics) post-TAVR.
What is the current status of trial NCT04827238?
This trial is currently completed. The enrollment target is 49 participants. The study started on 2021-08-30. Estimated completion is 2025-06-20.
What conditions does trial NCT04827238 study?
This clinical trial studies the following conditions: Aortic Valve Stenosis, Aortic Stenosis.
What interventions are being tested in trial NCT04827238?
The interventions under investigation include: Standardized Invasive Hemodynamics (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT04827238?
This trial is sponsored by University of British Columbia, which has 18 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04827238 being conducted?
This trial has 9 study locations across Arizona, Florida, Indiana, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Aortic Valve Stenosis
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04827238's enrollment target sits among peer trials
49 26th of 30 higher than 5 of 30 other Aortic Valve Stenosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aortic Valve Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
STS/ACC Transcatheter Valve Therapy Registry (TVT Registry)
RECRUITING
-
Intravascular Lithotripsy in High Risk Calcified Iliac Anatomy for Transfemoral TAVR
RECRUITING
-
Platelet Adhesion in the Pathobiology of Aortic Stenosis
RECRUITING
-
Imaging Histone Deacetylase in the Heart
RECRUITING · NA
-
MRI in Transcatheter Aortic Valve Replacement Patients
RECRUITING · NA
-
Detecting Changes in Arterial Blood Volume and Cardiac Efficiency
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT02704858 · 49 participants · Phase 1
Safety and Efficacy Study in Recurrent or Progressive Grade III or IV IDH1 Mutated Glioma
- NCT03516708 · 49 participants · Phase 1
Epacadostat (INCB024360) Added to Preoperative Chemoradiation in Patients With Locally Advanced Rectal Cancer
- NCT03692429 · 49 participants · Phase 1
alloSHRINK - Standard cHemotherapy Regimen and Immunotherapy With Allogeneic NKG2D-based CYAD-101 Chimeric Antigen Receptor T-cells
- NCT04329494 · 49 participants · Phase 1
PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI