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ClinicalTrials.gov 13 recruiting now official registry

Polycystic Ovary Syndrome clinical trials

13 of 31 indexed Polycystic Ovary Syndrome trials are currently recruiting.

31 US clinical trials · 13 currently recruiting

Polycystic Ovary Syndrome is the subject of 31 registered US clinical trials on ClinicalTrials.gov, 13 of them currently open to new participants. 3 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is University of Virginia, running 4 of these trials.

The research picture

Polycystic Ovary Syndrome has 31 registered US clinical trials, 13 of them open to new participants right now, about 42% of the total.

13
recruiting participants now
42%
of trials open to enrollment
3
in Phase 3–4 (later-stage)
4
top sponsor: University of Virginia
Phase 15Phase 22Phase 31Phase 42

Active & Recent Trials

31 total, page 1 of 1

RECRUITING 500,000 participants

Apple Women's Health Study

Apple

NCT04196595

RECRUITING 15,000 participants

The PCOS Challenge Study

PCOS Challenge: The National Polycystic Ovary Syndrome Association

NCT05797909

RECRUITING 500 participants

Fasting Insulin and HOMA-IR by Age, Sex, Race/Ethnicity, BMI, and PCOS Diagnosis

Lilli Health

NCT05950282

RECRUITING NA 300 participants

IVM With Low Cost Priming, Enhanced Oocyte Recovery, and Delayed Transfer

Bruce Rose, MD

NCT04149496

RECRUITING NA 195 participants

The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

May Health

NCT06206746

RECRUITING NA 168 participants

Myo-Inositol for Infertility in PCOS

University of Oklahoma

NCT04407754

RECRUITING Early Phase 1 144 participants

Relative Contributions of Predictors of Hyperandrogenism in Older vs. Young Women With PCOS

University of Virginia

NCT03905603

RECRUITING Phase 2 100 participants

Combined Oral Contraceptive Pill and Resistance Starch

University of Pennsylvania

NCT06852365

RECRUITING Phase 1 100 participants

The Physiological Responses and Adaptation of Brown Adipose Tissue to Chronic Treatment With Beta3-Adrenergic Receptor Agonists

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

NCT03049462

RECRUITING NA 95 participants

Lifestyle Medicine: Establishing Clinical Approaches to Chronic Disease for Rural Patients

West Virginia School of Osteopathic Medicine

NCT06049420

RECRUITING Early Phase 1 37 participants

Study to Assess Potential Impairments in Estradiol Augmentation of Gonadotropin Secretion in Polycystic Ovary Syndrome

University of Virginia

NCT03401047

RECRUITING Early Phase 1 32 participants

Does Spironolactone Normalize Sleep-wake Luteinizing Hormone Pulse Frequency in Pubertal Girls With Hyperandrogenism?

University of Virginia

NCT04723862

RECRUITING Early Phase 1 32 participants

Hyperandrogenemia and Altered Day-night LH Pulse Patterns

University of Virginia

NCT03068910

ACTIVE NOT RECRUITING Phase 4 190 participants

Randomized Controlled Trial of Combined Letrozole and Clomid (CLC II) Versus Letrozole Alone for Women With Anovulation

Rachel Mejia

NCT05206448

ACTIVE NOT RECRUITING NA 70 participants

A Study to Evaluate the Effect of Elix Cycle Balance and Daily Harmony on Polycystic Ovary Syndrome

Zenchi

NCT05875233

ACTIVE NOT RECRUITING NA 47 participants

PCOS & Insulin Resistance Exercise Study

University of California, San Francisco

NCT02303470

ACTIVE NOT RECRUITING 36 participants

Adipose Tissue and Polycystic Ovary Syndrome (PCOS)(EIFFEL)

AdventHealth Translational Research Institute

NCT01745471

ACTIVE NOT RECRUITING NA 20 participants

Restoring Metabolic and Reproductive Health With Sleep in PCOS Study, CPAP Trial

University of California, San Francisco

NCT05920694

COMPLETED 126 participants

Comparison of Lifestyle Markers Between Women With and Without Polycystic Ovary Syndrome

Cornell University

NCT01859663

COMPLETED NA 97 participants

Metabolic Syndrome in PCOS: Precursors and Interventions

Northwestern University

NCT00442689

COMPLETED NA 79 participants

Insulin and the Polycystic Ovary Syndrome--Weight Reduction Study

Virginia Commonwealth University

NCT00436865

COMPLETED Phase 4 79 participants

Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS

Maimonides Medical Center

NCT03644212

COMPLETED NA 47 participants

Evaluation of Vitamin D in Women With PCOS and Sexual Dysfunction

Wright State University

NCT02865187

COMPLETED NA 41 participants

Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome

University of California, San Diego

NCT00989781

COMPLETED NA 40 participants

Effects of a Female Hormone Balance Supplement on Symptoms of Polycystic Ovary Syndrome and Severe Premenstrual Syndrome

Rael

NCT06124300

COMPLETED NA 40 participants

A Single Group Study to Evaluate the Effects of a Myo-Inositol and D-Chiro Inositol Supplement on Symptoms Associated With Polycystic Ovary Syndrome and Hormone Imbalance

Optify

NCT06158932

COMPLETED NA 39 participants

Ovarian Morphology and Theca Cell Androgen Production in Women With Polycystic Ovary Syndrome (PCOS)

University of California, San Diego

NCT02145247

COMPLETED Phase 3 38 participants

Saxagliptin + Metformin Compared to Saxagliptin or Metformin Monotherapy in PCOS Women With Impaired Glucose Homeostasis

Woman's

NCT02022007

COMPLETED Phase 2 20 participants

A Trial of Lipitor (Atorvastatin) for the Treatment of Polycystic Ovary Syndrome (PCOS) in Women With Elevated Low-density Lipoprotein (LDL) Cholesterol

Milton S. Hershey Medical Center

NCT00529542

COMPLETED NA 18 participants

Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea

University of Chicago

NCT00696111

COMPLETED NA 8 participants

Effects of Exercise for Overweight Women With Polycystic Ovary Syndrome

Pennington Biomedical Research Center

NCT01150539

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 2
Phase 3 1
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Polycystic Ovary Syndrome Trial Landscape

31 indexed Polycystic Ovary Syndrome studies · 13 recruiting (42%).

Phase mix: 3 late (III/IV) vs 7 early (I/II).

Top sponsor: University of Virginia (4 trials), 9 others listed. 31 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Polycystic Ovary Syndrome?

PlainTrial tracks 31 US clinical trials for Polycystic Ovary Syndrome, of which 13 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Polycystic Ovary Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.