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NCT05550896 · ClinicalTrials.gov registry record
Platelet Adhesion in the Pathobiology of Aortic Stenosis
A clinical trial of Aortic Valve Stenosis, sponsored by University of Virginia.
- Recruiting
- Registry status
- 65
- Enrollment target
- 1
- Study location
NCT05550896 is a study of Aortic Valve Stenosis that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 65 participants, below the 1,041-participant average among 30 other Aortic Valve Stenosis trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state.
The verdict
NCT05550896, a study of Aortic Valve Stenosis, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- 65 participants
- Enrollment target
- 1
- Study location
Study Summary
Aortic stenosis (AS) is a serious and common condition that affects 2-3% of the population \>65 years of age in Western countries. It is also responsible for extraordinarily high healthcare expenditures, estimated to be over $6 billion annually,2 in part because the primary treatment for severe AS is aortic valve replacement (AVR) which is resource-intensive. Valve abnormalities are frequently recognized before AS becomes severe, or before there is need for guideline-directed procedural intervention, thereby providing an opportunity for pharmacologic intervention to slow disease progression. Yet, all attempts to prevent AS progression in those with degenerative non-congenital forms of disease have failed. The only non-procedural intervention that benefits patients with moderate or greater AS is the aggressive treatment of hypertension, which reduces net left ventricular (LV) afterload (valvulo-arterial impedance \[Zva\]) and can slow secondary LV remodeling. The overall goal of this proposal is to integrate advanced imaging and vascular biology to study how von Willebrand factor (VWF) and platelet adhesion promote AS progression through many parallel pathways, thereby representing a potential therapeutic target. We are hypothesizing that blood markers of abnormal VWF proteolysis and platelet-derived factors, and abnormal valve shear patterns which can be detected by advanced analysis of spectral Doppler on echocardiography are predictors for progressive AS.
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Echocardiogaphy
Study Locations (1)
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2023-01-03 |
| Est. Completion | 2028-06-01 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05550896
The ClinicalTrials.gov registry entry for NCT05550896 describes a study currently listed as recruiting, categorized as an unspecified phase. The registered enrollment target is 65 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 1,041-participant average among 30 other Aortic Valve Stenosis trials with a reported enrollment target (94% lower). The listed sponsor is University of Virginia, which has 449 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Aortic Valve Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Echocardiogaphy is the first listed.
NCT05550896 reports 1 study location spanning 1 distinct geographic area - top geographies include Virginia.
Frequently Asked Questions
What is clinical trial NCT05550896 about?
NCT05550896 is a clinical study titled "Platelet Adhesion in the Pathobiology of Aortic Stenosis". Aortic stenosis (AS) is a serious and common condition that affects 2-3% of the population \>65 years of age in Western countries. It is also responsible for extraordinarily high healthcare expenditures, estimated to be over $6 billion annually,2 in part because the primary treatment for severe AS i...
What is the current status of trial NCT05550896?
This trial is currently recruiting. The enrollment target is 65 participants. The study started on 2023-01-03. Estimated completion is 2028-06-01.
What conditions does trial NCT05550896 study?
This clinical trial studies the following conditions: Aortic Valve Stenosis.
What interventions are being tested in trial NCT05550896?
The interventions under investigation include: Echocardiogaphy (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT05550896?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05550896 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.