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ClinicalTrials.gov 42 recruiting now official registry

Anxiety Disorders clinical trials

42 of 85 indexed Anxiety Disorders trials are currently recruiting.

85 US clinical trials · 42 currently recruiting

Anxiety Disorders is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 5 of these trials.

The research picture

Anxiety Disorders has 85 registered US clinical trials, 42 of them open to new participants right now, about 49% of the total.

42
recruiting participants now
49%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
5
top sponsor: Massachusetts General Hospital
Phase 15Phase 26Phase 38Phase 42

Active & Recent Trials

85 total, page 1 of 2

RECRUITING 50,000 participants

RIVER At Home Ketamine Protocols

RIVER Foundation

NCT06070766

RECRUITING 16,000 participants

Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers

National Institute of Mental Health (NIMH)

NCT00024635

RECRUITING Phase 2 2,530 participants

Study of Neuro-Cognitive Correlates of Pediatric Anxiety Disorders

National Institute of Mental Health (NIMH)

NCT00018057

RECRUITING NA 2,500 participants

Clinical Study Evaluating Pharmacogenomics-informed Pharmacotherapy Versus Dosing as Usual in Psychiatric Disorders

Maastricht University Medical Center

NCT05656469

RECRUITING NA 2,448 participants

Enhancing Engagement by Integrating Goals and Concerns That Matter to Patients

Dartmouth-Hitchcock Medical Center

NCT06898593

RECRUITING NA 2,000 participants

Cultural Adaptation of a SSI for Youth Anxiety

University of Miami

NCT04729504

RECRUITING 1,500 participants

Resilience in Adolescent Development

University of Texas Southwestern Medical Center

NCT03458936

RECRUITING 1,000 participants

Technology Exposure and Child Health: Wellness Impact and Social Effects: an Observational Product Registry Study

Aura

NCT06664944

RECRUITING NA 600 participants

CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos

Drexel University

NCT06139159

RECRUITING 500 participants

Ketamine Treatment Plans for Chronic Conditions

RIVER Foundation

NCT06038409

RECRUITING 390 participants

Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders

National Institute of Mental Health (NIMH)

NCT00397111

RECRUITING NA 306 participants

Enhancing Psychotherapy for Veterans and Service Members With PTSD and Anxiety

Baylor College of Medicine

NCT05843695

RECRUITING NA 240 participants

Neurostimulation Versus Therapy for Problems With Emotions

Duke University

NCT05712057

RECRUITING NA 238 participants

Whole Health in VA Mental Health: Omnis Salutis

VA Office of Research and Development

NCT05400252

RECRUITING 200 participants

An Exploratory Study Examining Biopsychosocial Markers of Anxiety and Depression

Singula Institute

NCT05466851

RECRUITING NA 200 participants

A Comparison of Two School Based Interventions to Manage Anxiety in Autistic Students

University of Colorado, Denver

NCT05863520

RECRUITING NA 192 participants

A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

Massachusetts General Hospital

NCT06929442

RECRUITING NA 180 participants

Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety

University of Texas at Austin

NCT05427708

RECRUITING Phase 4 165 participants

Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression

Laureate Institute for Brain Research

NCT06004115

RECRUITING Phase 4 150 participants

Trial With the Treatment of Sertraline in Youth With Generalized, Separation and/or Social Anxiety Disorders.

University of Cincinnati

NCT04221997

RECRUITING Phase 2 150 participants

Gaze-Contingent Music Therapy Augmentation of CBT for Pediatric Anxiety

National Institute of Mental Health (NIMH)

NCT06595953

RECRUITING NA 150 participants

RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty

University of Pittsburgh

NCT05658796

RECRUITING NA 139 participants

Internet-delivered Cognitive-Behavioral Therapy for Adolescents With Autism and Anxiety

Baylor College of Medicine

NCT06537128

RECRUITING Phase 2 128 participants

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

University of California, San Diego

NCT06273527

RECRUITING NA 120 participants

Expansion and Evaluation of AI-generated Clinical Assessment (AI-COA®) of Depression and Anxiety Severity

Deliberate Solutions

NCT06923995

RECRUITING Phase 2 108 participants

Pramipexole to Enhance Social Connections

University of California, San Diego

NCT06269146

RECRUITING NA 100 participants

Reducing Mental Health Disparities Among Latinxs With a Telenovela Intervention

University of Nevada, Reno

NCT06163599

RECRUITING NA 96 participants

Pilot Effectiveness Trial of an ACT Self-help Workbook Tailored Specifically for Prisons

University of Wisconsin, Madison

NCT06162624

RECRUITING NA 95 participants

Initial Assessment of the Feasibility and Efficacy of a Scalable Digital CBT for Generalized Anxiety and Associated Health Behaviors in a Cardiovascular Disease Population

Boston University Charles River Campus

NCT04895995

RECRUITING NA 90 participants

Measurement-Based Care (MBC) Implementation, Effectiveness, and Mechanisms of Change

Carilion Clinic

NCT06671158

RECRUITING NA 90 participants

Online Parent Education for Child Anxiety

Massachusetts General Hospital

NCT07153250

RECRUITING Phase 3 90 participants

Cannabidiol-Assisted Learning for Managing Generalized Anxiety Disorder

Wayne State University

NCT07123467

RECRUITING NA 80 participants

Mindful Self-compassion for Anxiety and Depression: Impact of Delivery Method

Georgetown University

NCT07028216

RECRUITING NA 80 participants

Modulating Anxious Coping

Medical University of South Carolina

NCT04824105

RECRUITING NA 76 participants

Toward Understanding Drivers of Patient Engagement With Digital Mental Health Interventions - Part II

Brigham and Women's Hospital

NCT05555875

RECRUITING NA 70 participants

DINO RCT - Treating Anxiety in Children With Autism

Hugo W. Moser Research Institute at Kennedy Krieger

NCT06066983

RECRUITING NA 70 participants

Development of a Transdiagnostic Intervention for Adolescents at Risk for Serious Mental Illness

Massachusetts General Hospital

NCT05962879

RECRUITING NA 60 participants

Managing Anxiety in Pediatric Primary Care (MAPP)

UConn Health

NCT06104904

RECRUITING NA 54 participants

A Single Session Parenting Intervention for Children on a Outpatient Therapy Waitlist

Massachusetts General Hospital

NCT06043271

RECRUITING NA 40 participants

Mindful Self-Compassion for Anxiety Disorders and Depression

Georgetown University

NCT05671419

RECRUITING NA 40 participants

Modulating Escape Using Focused Ultrasound

Medical University of South Carolina

NCT06273904

RECRUITING NA 12 participants

Effectiveness of the SoundHeal Multi-Sensory Integrative Therapy Among Justice-Involved Youth

SoundHeal

NCT07364799

ACTIVE NOT RECRUITING Phase 3 316 participants

Fluoxetine vs CBT in Childhood Anxiety Disorders

Children's Hospital Los Angeles

NCT04760275

ACTIVE NOT RECRUITING NA 174 participants

Reconnecting to Ourselves and Others in Virtual Meetings (ROOM)

Massachusetts General Hospital

NCT06360562

ACTIVE NOT RECRUITING 60 participants

SKY Breath Intervention

University of California, San Francisco

NCT05388110

ACTIVE NOT RECRUITING NA 50 participants

TCI-Massage Clinical Trial

The Center for Victims of Torture, United States

NCT07482358

ACTIVE NOT RECRUITING NA 32 participants

Transitioning Emotionally and Academically to Middle School Successfully (TEAMSS)

UConn Health

NCT05145387

ACTIVE NOT RECRUITING NA 30 participants

Pre-Post Intervention Study to Investigate the Safety, Feasibility, & Efficacy of the NeurGear ZenBud System for the Treatment of Anxiety & Anxiety-Related Symptoms

NeurGear

NCT06574971

ACTIVE NOT RECRUITING NA 20 participants

Focused Ultrasound Amygdala Neuromodulation

University of Texas at Austin

NCT05228964

ACTIVE NOT RECRUITING NA 15 participants

PRISM for Depression and Anxiety in Young Adults With Cancer

Dana-Farber Cancer Institute

NCT06502483

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Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 6
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anxiety Disorders Trial Landscape

85 indexed Anxiety Disorders studies · 42 recruiting (49%).

Phase mix: 10 late (III/IV) vs 11 early (I/II).

Top sponsor: Massachusetts General Hospital (5 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anxiety Disorders?

PlainTrial tracks 85 US clinical trials for Anxiety Disorders, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anxiety Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.