Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 42 recruiting now official registry

Anxiety Disorders clinical trials

42 of 85 indexed Anxiety Disorders trials are currently recruiting.

85 US clinical trials · 42 currently recruiting

Anxiety Disorders is the subject of 85 registered US clinical trials on ClinicalTrials.gov, 42 of them currently open to new participants. 10 are in Phase 3-4 (later-stage) and 11 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 5 of these trials.

The research picture

Anxiety Disorders has 85 registered US clinical trials, 42 of them open to new participants right now, about 49% of the total.

42
recruiting participants now
49%
of trials open to enrollment
10
in Phase 3–4 (later-stage)
5
top sponsor: Massachusetts General Hospital
Phase 15Phase 26Phase 38Phase 42

Active & Recent Trials

85 total, page 2 of 2

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Testing a Transdiagnostic TMS Treatment Target

Brigham and Women's Hospital

NCT06282146

COMPLETED NA 6,205 participants

Harnessing Mobile Technology to Reduce Mental Health Disorders in College Populations

Washington University School of Medicine

NCT04162847

COMPLETED NA 895 participants

Transdiagnostic Behavioral Activation Therapy for Youth Anxiety and Depression

Rutgers University

NCT01829100

COMPLETED Phase 2 725 participants

AZD7325 Proof of Concept in Patients With Generalized Anxiety Disorder (GAD)

AstraZeneca

NCT00808249

COMPLETED Phase 3 575 participants

Safety and Efficacy Maintenance Study of Quetiapine SR to Treat GAD Patients.

AstraZeneca

NCT00314210

COMPLETED Phase 3 480 participants

A Comparison of Duloxetine Hydrochloride, Marketed Comparator, and Placebo in the Treatment of Generalized Anxiety Disorder

Eli Lilly and Company

NCT00122850

COMPLETED Phase 3 360 participants

Telephone-Based Care Management Program for Individuals With Anxiety Disorders

University of Pittsburgh

NCT00158327

COMPLETED NA 250 participants

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety Disorders

Boston University Charles River Campus

NCT01243606

COMPLETED NA 222 participants

A Cognitive-Behavioral Intervention for Depression and Anxiety in COPD

US Department of Veterans Affairs

NCT00105911

COMPLETED NA 216 participants

School-based Treatment of Anxiety Research Study (STARS)

UConn Health

NCT01761396

COMPLETED Phase 1 150 participants

Treatment for Specific Phobias in Children

Virginia Polytechnic Institute and State University

NCT00051220

COMPLETED NA 125 participants

Flourishing and Virtue in Cognitive-Behavioral Therapy for Anxiety and Depressive Disorders

Boston University Charles River Campus

NCT05120232

COMPLETED NA 124 participants

Explanatory Clinical Trial of a Novel Parent Intervention for Childhood Anxiety (SPACE)

Yale University

NCT02310152

COMPLETED Phase 3 120 participants

Quetiapine Extended Release (XR) in Bipolar Patients With Comorbid Generalized Anxiety Disorder (GAD)

University Hospitals Cleveland Medical Center

NCT00671853

COMPLETED NA 115 participants

Retraining Attention to Treat Alcohol Dependence and Social Anxiety

University of Cincinnati

NCT01886716

COMPLETED NA 110 participants

Family-Focused CBT Skills App and Standard Self Help Options for Childhood Anxiety

Kansas City Center for Anxiety Treatment, P.A.

NCT03269370

COMPLETED Phase 2 109 participants

Inhaled Oxytocin and HPA Axis Reactivity

University of North Carolina, Chapel Hill

NCT03593473

COMPLETED Phase 1 103 participants

Mindfulness-based Stress Reduction and Cognitive Function in Stress and Aging

Washington University School of Medicine

NCT01693874

COMPLETED NA 95 participants

Personalized Feedback for Smokers With Elevated Anxiety Sensitivity

University of Houston

NCT03382093

COMPLETED 89 participants

Feasibility of Collateral Information Review and Its Impact on Clinical Decision-Making

Mclean Hospital

NCT04635748

COMPLETED NA 88 participants

Reward Processes and Rehearsal in Exposure Therapy

University of California, Los Angeles

NCT06132425

COMPLETED Phase 1 68 participants

Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders

Louisiana State University and A&M College

NCT01875796

COMPLETED NA 61 participants

Transdiagnostic Sleep and Anxiety Treatment

Florida State University

NCT03664310

COMPLETED NA 59 participants

A Single-Session Intervention for Families on Waitlists for Child Anxiety Treatment

Florida International University

NCT05841680

COMPLETED NA 56 participants

Anxiety in Older Veterans

VA Office of Research and Development

NCT02400723

COMPLETED NA 50 participants

Threat Interpretation Bias as Cognitive Marker and Treatment Target in Pediatric Anxiety

University of Denver

NCT04245501

COMPLETED NA 45 participants

Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli

Georgetown University

NCT03206437

COMPLETED 45 participants

Evaluating a Personalized Trans-Diagnostic Group Therapy for Anxiety

Stanford University

NCT03457922

COMPLETED NA 42 participants

Benzodiazepine Taper With Cognitive Behavioral Therapy in Patients Using Prescription Opioids

University of California, Los Angeles

NCT05573906

COMPLETED NA 40 participants

Relaxation Treatment for Anxiety in Adults Aged 60 or Older

Palo Alto Veterans Institute for Research

NCT02429778

COMPLETED Phase 3 40 participants

School-based Treatment for Anxious Children

Johns Hopkins University

NCT00536094

COMPLETED NA 37 participants

Study of Treatment for Opioid Dependence and Anxiety Disorders

Mclean Hospital

NCT02252068

COMPLETED Phase 3 30 participants

Treatment Effects of Escitalopram (Lexapro®) on Generalized Anxiety Disorder in Patients With HIV and AIDS

Duke University

NCT00887679

COMPLETED NA 27 participants

Strategies for Treating Anxiety Research Study

University of Nevada, Las Vegas

NCT05398016

COMPLETED Phase 1 15 participants

Antiglucocorticoid Therapy for Cognitive Impairment in Late-life Anxiety Disorders

Washington University School of Medicine

NCT01333098

← Previous Page 2 of 2

Phase Distribution

PhaseTrial count
Phase 1 5
Phase 2 6
Phase 3 8
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Anxiety Disorders Trial Landscape

85 indexed Anxiety Disorders studies · 42 recruiting (49%).

Phase mix: 10 late (III/IV) vs 11 early (I/II).

Top sponsor: Massachusetts General Hospital (5 trials), 9 others listed. 35 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Anxiety Disorders?

PlainTrial tracks 85 US clinical trials for Anxiety Disorders, of which 42 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Anxiety Disorders?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.