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NCT04574167 · ClinicalTrials.gov registry record · NA
Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans
A NA study of Alcohol Use Disorder, sponsored by VA Office of Research and Development.
- Completed
- Registry status
- NA
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT04574167: Completed NA study of Alcohol Use Disorder, sponsored by VA Office of Research and Development.
NCT04574167 is a NA study of Alcohol Use Disorder that has completed, run by VA Office of Research and Development. The registered enrollment target is 45 participants, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (86% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04574167, a NA study of Alcohol Use Disorder, has completed, sponsored by VA Office of Research and Development.
- COMPLETED
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
Alcohol misuse is an epidemic among Veterans in the United States. Nearly 1/3 of Veterans have a lifetime history of Alcohol Use Disorder (AUD). In 2014, there were 15,306 unique patients treated in inpatient VA treatment programs alone, which represents a 10.7% increase from just two years prior. Unfortunately, about 2/3 of those entering treatment will relapse within one year. Cognitive impairments found in chronic alcohol use interfere with adaptive behavior needed for successful recovery. These cognitive impairments and their underlying neural substrates may provide promising new targets for interventions that can reduce relapse rates. Evidence suggests that cognitive training can improve cognition in individuals with AUD, strengthen neural networks mediating cognition, and improve treatment outcome. However, cognitive training is effort intensive, has small effect sizes, and may have limited durability. The primary objective of this study is to investigate if transcranial direct current stimulation (tDCS) can increase the effectiveness of cognitive training to enhance cognition in alcohol use disorder and improve treatment outcome.
Primary Outcome
Participants will complete MRI sessions on a 3T scanner located in the Center for Magnetic Resonance Research (CMRR) at the University of Minnesota. Participants will undergo resting-state MRI over a 12-minute scan in order to gather resting state functional connectivity (RSFC). Hierarchical linear models will examine differences in change in target engagement (frontal-striatal RSFC) between active and sham tDCS conditions.
Conditions Studied
Interventions
- DEVICE Sham Transcranial Direct Current Stimulation (tDCS)
- DEVICE Active Transcranial Direct Current Stimulation (tDCS)
Study Locations (1)
Minnesota
- Minneapolis VA Health Care System, Minneapolis, MN - Minneapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2020-01-01 |
| Est. Completion | 2026-03-06 |
| Phase | NA |
What the finished NCT04574167 record still lists
NCT04574167 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 328-participant average among 184 other Alcohol Use Disorder trials with a reported enrollment target (86% lower).
The record links to 1 condition, with Alcohol Use Disorder appearing as the primary indexed condition, and to 2 interventions - of which Sham Transcranial Direct Current Stimulation (tDCS) is the first listed.
NCT04574167 reports a single indexed study location in Minnesota.
Frequently Asked Questions
What is clinical trial NCT04574167 about?
NCT04574167 is a clinical study titled "Effects of tDCS Paired With Cognitive Training on Brain Networks Associated With Alcohol Use Disorder in Veterans". Alcohol misuse is an epidemic among Veterans in the United States. Nearly 1/3 of Veterans have a lifetime history of Alcohol Use Disorder (AUD). In 2014, there were 15,306 unique patients treated in inpatient VA treatment programs alone, which represents a 10.7% increase from just two years prior. U...
What is the current status of trial NCT04574167?
This trial is currently completed. It is a NA study. The enrollment target is 45 participants. The study started on 2020-01-01. Estimated completion is 2026-03-06.
What conditions does trial NCT04574167 study?
This clinical trial studies the following conditions: Alcohol Use Disorder.
What interventions are being tested in trial NCT04574167?
The interventions under investigation include: Sham Transcranial Direct Current Stimulation (tDCS) (DEVICE), Active Transcranial Direct Current Stimulation (tDCS) (DEVICE).
Who is sponsoring clinical trial NCT04574167?
This trial is sponsored by VA Office of Research and Development, which has 1,668 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04574167 being conducted?
This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04574167's enrollment target sits among peer trials
45 133rd of 184 higher than 51 of 184 other Alcohol Use Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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