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NCT06070649 · ClinicalTrials.gov registry record · Phase 1
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
A Phase 1 study of Alcohol Use Disorder (AUD) and Alcohol-Related Disorders, sponsored by Yale University.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 63
- Enrollment target
- 1
- Study location
NCT06070649: Recruiting Phase 1 study of Alcohol Use Disorder (AUD) and Alcohol-Related Disorders, sponsored by Yale University.
NCT06070649 is a Phase 1 study of Alcohol Use Disorder (AUD) and Alcohol-Related Disorders that is actively recruiting participants, run by Yale University. The registered enrollment target is 63 participants, below the 1,822-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (97% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06070649, a Phase 1 study of Alcohol Use Disorder (AUD) and Alcohol-Related Disorders, is actively recruiting participants, sponsored by Yale University.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 63 participants
- Enrollment target
- 1
- Study location
Study Summary
This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.
Primary Outcome
Systematic Assessment for Treatment Emergent Effects (SAFTEE) and MedDRA will be used weekly for 8 weeks to assess safety and tolerability of DMT in women and men with AUD.
Conditions Studied
Interventions
- DRUG 0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion
- DRUG 0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion
- DRUG 25 mg Diphenhydramine (5 min) + Normal Saline
Study Locations (1)
Connecticut
- Connecticut Mental Health Center - New Haven
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 63 participants |
| Start Date | 2025-08-04 |
| Est. Completion | 2026-08-01 |
| Phase | Phase 1 |
What NCT06070649 shows while recruiting
NCT06070649 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 63 participants, a relatively small participant target, below the 1,822-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (97% lower).
The record links to 3 conditions, with Alcohol Use Disorder (AUD) appearing as the primary indexed condition, and to 3 interventions - of which 0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion is the first listed.
NCT06070649 reports a single indexed study location in Connecticut.
Frequently Asked Questions
What is clinical trial NCT06070649 about?
NCT06070649 is a clinical study titled "The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)". This proposed study is a double-blind, randomized, placebo-controlled, parallel-group, laboratory study to determine the effects of DMT, plus psychotherapy, on Alcohol Use Disorder.
What is the current status of trial NCT06070649?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 63 participants. The study started on 2025-08-04. Estimated completion is 2026-08-01.
What conditions does trial NCT06070649 study?
This clinical trial studies the following conditions: Alcohol Use Disorder (AUD), Alcohol-Related Disorders, Alcohol Use.
What interventions are being tested in trial NCT06070649?
The interventions under investigation include: 0.3mg/kg/min Dimethyltryptamine + Normal Saline infusion (DRUG), 0.2 mg/kg/min + Dimethyltryptamine 0.01mg/kg/min infusion (DRUG), 25 mg Diphenhydramine (5 min) + Normal Saline (DRUG).
Who is sponsoring clinical trial NCT06070649?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06070649 being conducted?
This trial has 1 study location across Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder (AUD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06070649's enrollment target sits among peer trials
63 20th of 30 higher than 10 of 30 other Alcohol Use Disorder (AUD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder (AUD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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