Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT07118618 · ClinicalTrials.gov registry record · Phase 2
Probenecid Administration for Alcohol Craving and Consumption
A Phase 2 study of Alcohol Use Disorder (AUD) and Alcohol Consumption, sponsored by Brown University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT07118618: Recruiting Phase 2 study of Alcohol Use Disorder (AUD) and Alcohol Consumption, sponsored by Brown University.
NCT07118618 is a Phase 2 study of Alcohol Use Disorder (AUD) and Alcohol Consumption that is actively recruiting participants, run by Brown University. The registered enrollment target is 120 participants, below the 1,820-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07118618, a Phase 2 study of Alcohol Use Disorder (AUD) and Alcohol Consumption, is actively recruiting participants, sponsored by Brown University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
Primary Outcome
Acute alcohol craving during an alcohol cue-reactivity procedure assessed using change in the alcohol urge questionnaire (AUQ). AUQ consists of eight statements about the respondent's feelings and thoughts about drinking as they are completing the questionnaire (i.e., right now). Drinking refers to various types of alcohol, including beer, wine and liquor. The respondent is asked to respond to each statement about alcohol craving via a 7-item Likert scale ranging from "strongly disagree" to "str
Conditions Studied
Interventions
- DRUG Placebo Oral Tablet
- DRUG Probenecid Oral Tablet
Study Locations (1)
Rhode Island
- Brown University - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2026-03-14 |
| Est. Completion | 2030-12-31 |
| Phase | Phase 2 |
What NCT07118618 shows while recruiting
NCT07118618 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, below the 1,820-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (93% lower).
The record links to 3 conditions, with Alcohol Use Disorder (AUD) appearing as the primary indexed condition, and to 2 interventions - of which Placebo Oral Tablet is the first listed.
NCT07118618 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT07118618 about?
NCT07118618 is a clinical study titled "Probenecid Administration for Alcohol Craving and Consumption". This study proposes a 16-week, between-subject, double-blind, randomized controlled trial (RCT) with probenecid (2g /day) compared to placebo in individuals with AUD to test if reduces craving and alcohol consumption.
What is the current status of trial NCT07118618?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 120 participants. The study started on 2026-03-14. Estimated completion is 2030-12-31.
What conditions does trial NCT07118618 study?
This clinical trial studies the following conditions: Alcohol Use Disorder (AUD), Alcohol Consumption, Craving.
What interventions are being tested in trial NCT07118618?
The interventions under investigation include: Placebo Oral Tablet (DRUG), Probenecid Oral Tablet (DRUG).
Who is sponsoring clinical trial NCT07118618?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07118618 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder (AUD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07118618's enrollment target sits among peer trials
120 13th of 30 higher than 18 of 30 other Alcohol Use Disorder (AUD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder (AUD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
RECRUITING · Phase 2
-
Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: Pilot Study 3 Semaglutide
RECRUITING · Phase 2
-
Psilocybin With Psychological Support (Psi-PS) for Military Veterans and First Responders With Co-occurring PTSD & Alcohol Use Disorder (AUD)
RECRUITING · Phase 2
-
Study of Tirzepatide for Recovery and Alcohol Use Management
RECRUITING · Phase 2
-
Pharmaceutically-Enhanced Reinforcement for Reduced Alcohol and Smoking
RECRUITING · Phase 2
-
Suvorexant for Treatment of AUD and PTSD
RECRUITING · Phase 2
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01174108 · 120 participants · Phase 2
Allogeneic Hematopoietic Stem Cell Transplantation for Severe Aplastic Anemia and Other Bone Marrow Failure Syndromes Using G-CSF Mobilized CD34+ Selected Hematopoietic Precursor Cells Co-Infused With a Reduced Dose of Non-Mobilized Donor T-cells
- NCT01627301 · 120 participants · NA
Sympathetic Overactivity in Post-traumatic Stress Disorder
- NCT02025023 · 120 participants · Phase 3
Local 5-Fluorouracil Injection for the Treatment of Chalazia: A Prospective, Comparative Study
- NCT02128906 · 120 participants · Phase 2
Radiotherapy With Cisplatin vs. Docetaxel-cetuximab in HNSCC: ERCC1 Biomarker Enrichment and Interaction Design
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI