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NCT04135846 · ClinicalTrials.gov registry record · Phase 2
Alpha-1 Blockade for Alcohol Use Disorder (AUD)
A Phase 2 study of Alcohol Use Disorder (AUD), sponsored by Brown University.
- Recruiting
- Registry status
- Phase 2
- Development phase
- 184
- Enrollment target
- 1
- Study location
NCT04135846: Recruiting Phase 2 study of Alcohol Use Disorder (AUD), sponsored by Brown University.
NCT04135846 is a Phase 2 study of Alcohol Use Disorder (AUD) that is actively recruiting participants, run by Brown University. The registered enrollment target is 184 participants, below the 1,818-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (90% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04135846, a Phase 2 study of Alcohol Use Disorder (AUD), is actively recruiting participants, sponsored by Brown University.
- RECRUITING
- Registry status
- Phase 2
- Development phase
- 184 participants
- Enrollment target
- 1
- Study location
Study Summary
The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
Primary Outcome
Number of drinks per week (DPW) in naturalistic condition as measured by the timeline follow-back (TLFB)
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Doxazosin
Study Locations (1)
Rhode Island
- Brown University - Providence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 184 participants |
| Start Date | 2019-12-19 |
| Est. Completion | 2026-08-31 |
| Phase | Phase 2 |
What NCT04135846 shows while recruiting
NCT04135846 is an interventional study that assigns participants to a tested intervention. The registered 184 participants enrollment target is mid-sized for trials with a published cap, below the 1,818-participant average among 30 other Alcohol Use Disorder (AUD) trials with a reported enrollment target (90% lower).
The record links to 1 condition, with Alcohol Use Disorder (AUD) appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT04135846 reports a single indexed study location in Rhode Island.
Frequently Asked Questions
What is clinical trial NCT04135846 about?
NCT04135846 is a clinical study titled "Alpha-1 Blockade for Alcohol Use Disorder (AUD)". The goal of this research is to replicate findings previously conducted in a pilot trial and to understand, mechanistically, the role of stress in the development of AUD pharmacotherapies that target noradrenergic blockade.
What is the current status of trial NCT04135846?
This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 184 participants. The study started on 2019-12-19. Estimated completion is 2026-08-31.
What conditions does trial NCT04135846 study?
This clinical trial studies the following conditions: Alcohol Use Disorder (AUD).
What interventions are being tested in trial NCT04135846?
The interventions under investigation include: Placebo (DRUG), Doxazosin (DRUG).
Who is sponsoring clinical trial NCT04135846?
This trial is sponsored by Brown University, which has 231 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04135846 being conducted?
This trial has 1 study location across Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alcohol Use Disorder (AUD)
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04135846's enrollment target sits among peer trials
184 11th of 30 higher than 20 of 30 other Alcohol Use Disorder (AUD) trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alcohol Use Disorder (AUD) trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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