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A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors
NCT02671435 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, open-label, dose-escalation, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, pharmacokinetic (PK), pharmacodynamics, and immunogenicity of durvalumab (MEDI4736) in combination with monalizumab (IPH2201) in adult participants with selected advanced solid tumors and the combination of durvalumab and monalizumab (IPH2201) standard of care systemic therapy with or without biological agent and monalizumab (IPH2201) with biological agent administered to participants with recurrent or metastatic colorectal cancer (CRC).
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Cetuximab
- DRUG Durvalumab
- DRUG Monalizumab
- DRUG mFOLFOX6
Study Locations (20)
California
- Research Site — Duarte
- Research Site — La Jolla
- Research Site — Los Angeles
- Research Site — Sacramento
- Research Site — Santa Monica
New York
- Research Site — New Hyde Park
- Research Site — New York
- Research Site — The Bronx
Alabama
- Research Site — Birmingham
Arizona
- Research Site — Scottsdale
Colorado
- Research Site — Aurora
Florida
- Research Site — Tampa
Illinois
- Research Site — Chicago
Maryland
- Research Site — Baltimore
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 383 participants |
| Start Date | 2016-02-22 |
| Est. Completion | 2025-09-01 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02671435
The ClinicalTrials.gov registry entry for NCT02671435 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 383 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is MedImmune, which has 55 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Advanced Solid Tumors appearing as the primary indexed condition, and to 5 interventions — of which Bevacizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02671435 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, New York, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02671435 about?
NCT02671435 is a clinical study titled "A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors". This is a multicenter, open-label, dose-escalation, dose-exploration and dose-expansion study to evaluate the safety, tolerability, antitumor activity, pharmacokinetic (PK), pharmacodynamics, and immunogenicity of durvalumab (MEDI4736) in combination with monalizumab (IPH2201) in adult participants ...
What is the current status of trial NCT02671435?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 383 participants. The study started on 2016-02-22. Estimated completion is 2025-09-01.
What conditions does trial NCT02671435 study?
This clinical trial studies the following conditions: Advanced Solid Tumors. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02671435?
The interventions under investigation include: Bevacizumab (DRUG), Cetuximab (DRUG), Durvalumab (DRUG), Monalizumab (DRUG), mFOLFOX6 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02671435?
This trial is sponsored by MedImmune, which has 55 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02671435 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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