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A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors
NCT03893955 · View on ClinicalTrials.gov ↗
Study Summary
A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. The dose-expansion phase can begin once the recommended phase 2 dose/maximum tolerated dose (RP2D/MTD) is determined in the dose-escalation phase.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Nab-paclitaxel
- DRUG ABBV-927
- DRUG ABBV-181
- DRUG ABBV-368
Study Locations (20)
North Carolina
- Duke Cancer Center /ID# 217641 — Durham
- Carolina BioOncology Institute /ID# 210664 — Huntersville
Texas
- Mary Crowley Cancer Research /ID# 210716 — Dallas
- NEXT Oncology /ID# 210717 — San Antonio
Other
- Centre Jean Perrin /ID# 217911 — Clermont-Ferrand
- AP-HP - Hopital Bichat - Claude-Bernard /ID# 212869 — Paris
Arkansas
- Highlands Oncology Group, PA /ID# 218863 — Springdale
California
- St Jude Hospital dba St Joseph /ID# 211130 — Santa Rosa
Connecticut
- Yale University School of Medicine /ID# 210678 — New Haven
Florida
- Moffitt Cancer Center /ID# 215037 — Tampa
Indiana
- Fort Wayne Medical Oncology and Hematology, Inc /ID# 226072 — Fort Wayne
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 150 participants |
| Start Date | 2019-05-21 |
| Est. Completion | 2026-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03893955
The ClinicalTrials.gov registry entry for NCT03893955 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 150 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AbbVie, which has 603 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Cancer appearing as the primary indexed condition, and to 5 interventions — of which Carboplatin is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03893955 reports 20 study locations spanning 17 distinct geographic areas — top geographies include North Carolina, Texas, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03893955 about?
NCT03893955 is a clinical study titled "A Study to Determine the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of ABBV-927 With ABBV-368, Budigalimab (ABBV-181) and/or Chemotherapy in Participants With Locally Advanced or Metastatic Solid Tumors". A study evaluating the safety, pharmacokinetics (PK), pharmacodynamics, and preliminary efficacy of ABBV-927 with ABBV-368, Budigalimab (ABBV-181) and/or chemotherapy in participants with selected solid tumors. This study consists of 2 main parts, a dose-escalation phase and a dose-expansion phase. ...
What is the current status of trial NCT03893955?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 150 participants. The study started on 2019-05-21. Estimated completion is 2026-03.
What conditions does trial NCT03893955 study?
This clinical trial studies the following conditions: Cancer, Advanced Solid Tumors, Metastatic Solid Tumors, Triple-Negative Breast Cancer (TNBC), Non-small-cell-lung-cancer (NSCLC). These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03893955?
The interventions under investigation include: Carboplatin (DRUG), Nab-paclitaxel (DRUG), ABBV-927 (DRUG), ABBV-181 (DRUG), ABBV-368 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03893955?
This trial is sponsored by AbbVie, which has 603 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03893955 being conducted?
This trial has 20 study locations across Arkansas, California, Connecticut, Florida, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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