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NCT04449874 · ClinicalTrials.gov registry record · Phase 1
A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation
A Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer, sponsored by Genentech.
- Active
- Registry status
- Phase 1
- Development phase
- 498
- Enrollment target
- 20
- Study locations
NCT04449874 is a Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer that is active but no longer recruiting, run by Genentech. The registered enrollment target is 498 participants, below the 658-participant average among 449 other Non-Small Cell Lung Cancer trials with a reported enrollment target (24% lower). The trial reports 20 study locations across 13 states.
The verdict
NCT04449874, a Phase 1 study of Non-Small Cell Lung Cancer and Colorectal Cancer, is active but no longer recruiting, sponsored by Genentech.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 498 participants
- Enrollment target
- 20
- Study locations
Study Summary
This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.
Conditions Studied
Interventions
- DRUG Bevacizumab
- DRUG Atezolizumab
- DRUG Cetuximab
- DRUG Erlotinib
- DRUG GDC-6036
Study Locations (20)
California
- City of Hope Comprehensive Cancer Center - Duarte
- UCSD Moores Cancer Center - La Jolla
- Chao Family Comprehensive Cancer Center UCI - Orange
Other
- UZ Antwerpen - Edegem
- CHU de Liège - Liège
- AZ St Maarten Campus Leopoldstr - Mechelen
Pennsylvania
- Abramson Cancer Center - Philadelphia
- UPMC - Hillman Cancer Center - Pittsburgh
New South Wales
- St Vincent's Hospital Sydney - Darlinghurst
- Slade Health Inward goods - Mount Kuring-Gai
Victoria
- Peter MacCallum Cancer Center - Melbourne
- Alfred Health - Melbourne
Connecticut
- Yale Cancer Center - New Haven
Massachusetts
- Dana Farber Cancer Institute - Boston
Oklahoma
- University of Oklahoma - Oklahoma City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 498 participants |
| Start Date | 2020-07-29 |
| Est. Completion | 2027-12-31 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04449874
The ClinicalTrials.gov registry entry for NCT04449874 describes a study currently listed as active not recruiting, categorized as Phase 1. The registered enrollment target is 498 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 658-participant average among 449 other Non-Small Cell Lung Cancer trials with a reported enrollment target (24% lower). The listed sponsor is Genentech, which has 332 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Non-Small Cell Lung Cancer appearing as the primary indexed condition, and to 5 interventions - of which Bevacizumab is the first listed.
NCT04449874 reports 20 study locations spanning 13 distinct geographic areas - top geographies include California, Other, Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04449874 about?
NCT04449874 is a clinical study titled "A Study to Evaluate the Safety, Pharmacokinetics, and Activity of GDC-6036 Alone or in Combination in Participants With Advanced or Metastatic Solid Tumors With a KRAS G12C Mutation". This is a Phase I dose-escalation and dose-expansion study that will evaluate the safety, pharmacokinetics (PK), and preliminary activity of GDC-6036 in patients with advanced or metastatic solid tumors with a KRAS G12C mutation.
What is the current status of trial NCT04449874?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 498 participants. The study started on 2020-07-29. Estimated completion is 2027-12-31.
What conditions does trial NCT04449874 study?
This clinical trial studies the following conditions: Non-Small Cell Lung Cancer, Colorectal Cancer, Advanced Solid Tumors.
What interventions are being tested in trial NCT04449874?
The interventions under investigation include: Bevacizumab (DRUG), Atezolizumab (DRUG), Cetuximab (DRUG), Erlotinib (DRUG), GDC-6036 (DRUG).
Who is sponsoring clinical trial NCT04449874?
This trial is sponsored by Genentech, which has 332 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04449874 being conducted?
This trial has 20 study locations across California, Connecticut, Massachusetts, Oklahoma, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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