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Advanced Solid Tumors clinical trials
70 of 145 indexed Advanced Solid Tumors trials are currently recruiting.
145 US clinical trials · 70 currently recruiting
Advanced Solid Tumors is the subject of 145 registered US clinical trials on ClinicalTrials.gov, 70 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 144 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.
The research picture
Advanced Solid Tumors has 145 registered US clinical trials, 70 of them open to new participants right now, about 48% of the total.
- 70
- recruiting participants now
- 48%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 5
- top sponsor: Amgen
Active & Recent Trials
145 total, page 3 of 3
Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors
Novartis Pharmaceuticals
NCT01576666
A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors
Hoffmann-La Roche
NCT05240898
A Phase 1 Dose-escalation Study of OSI-906 and Erlotinib (Tarceva®)
Astellas Pharma
NCT00739453
Study of Continuous OSI-906 Dosing
Astellas Pharma
NCT00514007
Open-Label, Dose-Finding Study Evaluating Safety and PK of FPA144 in Patients With Advanced Solid Tumors
Five Prime Therapeutics
NCT02318329
A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors
Pfizer
NCT04672460
A First In Patient, Study Of Investigational Drug PF-03446962 In Patients With Advanced Solid Tumors
Pfizer
NCT00557856
A Study of HGS1029 (AEG40826-2HCl) in Subjects With Advanced Solid Tumors
Human Genome Sciences
NCT00708006
Study of Mogamulizumab + MEDI4736 (Durvalumab) and Mogamulizumab + Tremelimumab in Subjects w/ Advanced Solid Tumors
Kyowa Kirin
NCT02301130
Phase 1 Study of OSI-930 in Cancer Patients
Astellas Pharma
NCT00513851
A Study of ABT-806 in Subjects With Advanced Solid Tumor Types
AbbVie (prior sponsor, Abbott)
NCT01255657
Safety of TT-00420 (Tinengotinib) Monotherapy in Patients With Advanced Solid Tumors and Triple Negative Breast Cancer
TransThera Sciences (Nanjing)
NCT03654547
Study of Plitidepsin in Combination With Sorafenib or Gemcitabine in Patients With Advanced Solid Tumors or Lymphomas
PharmaMar
NCT00788099
Effect of Sapanisertib (MLN0128) on the QTc Interval in Participants With Advanced Solid Tumors
Calithera Biosciences
NCT02197572
Phase I Safety Study of the Drug MM-121 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment
Merrimack Pharmaceuticals
NCT00734305
A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Renal Impairment
Taiho Oncology
NCT02301117
A Study of ARRY-520 in Patients With Advanced Cancer
Array Biopharma, now a wholly owned subsidiary of Pfizer
NCT00462358
An Open-Label Pharmacokinetics and Safety Study of Talazoparib (MDV3800)
Pfizer
NCT02997176
Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma
Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U
NCT00996957
AMG 386 Drug-Drug Interaction Study With Paclitaxel
Amgen
NCT01992341
Dose-Escalation Phase 1 Study of G-202 (Mipsagargin) in Patients With Advanced Solid Tumors
GenSpera
NCT01056029
Study of Intravenous TCD-717 in Patients With Advanced Solid Tumors
Traslational Cancer Drugs Pharma, SL
NCT01215864
Safety Study of IMC-18F1,to Treat Advanced Solid Tumors in Subjects That no Longer Respond to Standard Therapy
Eli Lilly and Company
NCT00782002
Food Effect Study of Alisertib (MLN8237) in Participants With Advanced Solid Tumors or Lymphomas
Millennium Pharmaceuticals
NCT01898078
Pharmacokinetics and Safety of Panobinostat in Patients With Advanced Solid Tumors and Various Degrees of Hepatic Function
Novartis Pharmaceuticals
NCT01007968
A Study of AMG 820 in Subjects With Advanced Solid Tumors
AmMax Bio
NCT01444404
A Study of CS1001 in Subjects with Advanced Solid Tumors
CStone Pharmaceuticals
NCT03744403
Phase 1 Trial of the LSD1 Inhibitor SP-2577 (Seclidemstat) in Patients With Advanced Solid Tumors
Salarius Pharmaceuticals
NCT03895684
First-in-human Study of M4076 in Advanced Solid Tumors (DDRiver Solid Tumors 410)
EMD Serono Research & Development Institute
NCT04882917
Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer
R-Pharm
NCT00207090
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC61in Subjects With Advanced Solid Tumors
Ascletis Pharmaceuticals Co.
NCT05287399
Safety Study of ON 01910.Na in Combination With Irinotecan or Oxaliplatin
Traws Pharma
NCT00861328
A Phase 1/2, Open-Label, Dose-Escalation Study of JI-101, in Patients With Advanced Solid Tumors
Jubilant Innovation
NCT00842335
MK-2206, Paclitaxel and Trastuzumab in Treating Patients With HER2-overexpressing Solid Tumor Malignancies
University of California, San Francisco
NCT01235897
Safety, Tolerability, and Immunoregulatory Activity of Mogamulizumab (KW-0761) in Subjects With Advanced and/or Metastatic Solid Tumors
Memorial Sloan Kettering Cancer Center
NCT02281409
A Study of IMC-A12 Every 2 Weeks in Patients With Tumors Who No Longer Respond to Treatment or No Treatment is Available
Eli Lilly and Company
NCT00785941
Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors
Abbott
NCT01401933
A Rollover Study for Subjects That Have Participated in an Astellas Sponsored Linsitinib Trial
Astellas Pharma Global Development
NCT02057380
Study of Oral Darinaparsin in Patients With Advanced Solid Tumors
Alaunos Therapeutics
NCT01139346
Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors
Amgen
NCT04727554
Rollover Study for Subjects Who Have Participated in an Astellas Sponsored ASP2215 Trial
Astellas Pharma Global Development
NCT02561455
Study of the Mass Balance of Oral FTD and TPI as Components of TAS-102 in Patients With Advanced Solid Tumors
Taiho Oncology
NCT02031055
A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the Body
Astellas Pharma Global Development
NCT01529684
Study of NK012 and Carboplatin in Solid Tumors With Dose Expansion in Triple Negative Breast Cancer
Nippon Kayaku Co.
NCT01238952
Mass Balance, Pharmacokinetics and Metabolism Study of Alisertib
Millennium Pharmaceuticals
NCT01714947
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 137 |
| Phase 2 | 7 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Advanced Solid Tumors Trial Landscape
145 indexed Advanced Solid Tumors studies · 70 recruiting (48%).
Phase mix: 1 late (III/IV) vs 144 early (I/II).
Top sponsor: Amgen (5 trials), 9 others listed. 45 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Advanced Solid Tumors?
PlainTrial tracks 145 US clinical trials for Advanced Solid Tumors, of which 70 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Advanced Solid Tumors?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.