Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 70 recruiting now official registry

Advanced Solid Tumors clinical trials

70 of 145 indexed Advanced Solid Tumors trials are currently recruiting.

145 US clinical trials · 70 currently recruiting

Advanced Solid Tumors is the subject of 145 registered US clinical trials on ClinicalTrials.gov, 70 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 144 in Phase 1-2 (earlier-stage). The most active sponsor is Amgen, running 5 of these trials.

The research picture

Advanced Solid Tumors has 145 registered US clinical trials, 70 of them open to new participants right now, about 48% of the total.

70
recruiting participants now
48%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
5
top sponsor: Amgen
Phase 1137Phase 27Phase 31

Active & Recent Trials

145 total, page 3 of 3

COMPLETED Phase 1 120 participants

Phase Ib, Dose Escalation Study of Oral LDE225 in Combination With BKM120 in Patients With Advanced Solid Tumors

Novartis Pharmaceuticals

NCT01576666

COMPLETED Phase 1 116 participants

A Phase 1 Study of RO7623066 Alone and in Combination in Patients With Advanced Solid Tumors

Hoffmann-La Roche

NCT05240898

COMPLETED Phase 1 95 participants

A Phase 1 Dose-escalation Study of OSI-906 and Erlotinib (Tarceva®)

Astellas Pharma

NCT00739453

COMPLETED Phase 1 95 participants

Study of Continuous OSI-906 Dosing

Astellas Pharma

NCT00514007

COMPLETED Phase 1 79 participants

Open-Label, Dose-Finding Study Evaluating Safety and PK of FPA144 in Patients With Advanced Solid Tumors

Five Prime Therapeutics

NCT02318329

COMPLETED Phase 1 73 participants

A Bioequivalence Study Between the Proposed and Current Talazoparib Capsule Formulation and Food Effect Study for the Proposed Talazoparib Capsule Formulation in Participants With Advanced Solid Tumors

Pfizer

NCT04672460

COMPLETED Phase 1 70 participants

A First In Patient, Study Of Investigational Drug PF-03446962 In Patients With Advanced Solid Tumors

Pfizer

NCT00557856

COMPLETED Phase 1 66 participants

A Study of HGS1029 (AEG40826-2HCl) in Subjects With Advanced Solid Tumors

Human Genome Sciences

NCT00708006

COMPLETED Phase 1 64 participants

Study of Mogamulizumab + MEDI4736 (Durvalumab) and Mogamulizumab + Tremelimumab in Subjects w/ Advanced Solid Tumors

Kyowa Kirin

NCT02301130

COMPLETED Phase 1 60 participants

Phase 1 Study of OSI-930 in Cancer Patients

Astellas Pharma

NCT00513851

COMPLETED Phase 1 49 participants

A Study of ABT-806 in Subjects With Advanced Solid Tumor Types

AbbVie (prior sponsor, Abbott)

NCT01255657

COMPLETED Phase 1 48 participants

Safety of TT-00420 (Tinengotinib) Monotherapy in Patients With Advanced Solid Tumors and Triple Negative Breast Cancer

TransThera Sciences (Nanjing)

NCT03654547

COMPLETED Phase 1 45 participants

Study of Plitidepsin in Combination With Sorafenib or Gemcitabine in Patients With Advanced Solid Tumors or Lymphomas

PharmaMar

NCT00788099

COMPLETED Phase 1 44 participants

Effect of Sapanisertib (MLN0128) on the QTc Interval in Participants With Advanced Solid Tumors

Calithera Biosciences

NCT02197572

COMPLETED Phase 1 44 participants

Phase I Safety Study of the Drug MM-121 in Patients With Advanced Solid Tumors Resisting Ordinary Treatment

Merrimack Pharmaceuticals

NCT00734305

COMPLETED Phase 1 43 participants

A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Renal Impairment

Taiho Oncology

NCT02301117

COMPLETED Phase 1 41 participants

A Study of ARRY-520 in Patients With Advanced Cancer

Array Biopharma, now a wholly owned subsidiary of Pfizer

NCT00462358

COMPLETED Phase 1 38 participants

An Open-Label Pharmacokinetics and Safety Study of Talazoparib (MDV3800)

Pfizer

NCT02997176

COMPLETED Phase 1 37 participants

Study of ACE-041 in Patients With Advanced Solid Tumors or Relapsed/Refractory Multiple Myeloma

Acceleron Pharma, Inc., a wholly-owned subsidiary of Merck & Co., Inc., Rahway, NJ U

NCT00996957

COMPLETED Phase 1 35 participants

AMG 386 Drug-Drug Interaction Study With Paclitaxel

Amgen

NCT01992341

COMPLETED Phase 1 30 participants

Dose-Escalation Phase 1 Study of G-202 (Mipsagargin) in Patients With Advanced Solid Tumors

GenSpera

NCT01056029

COMPLETED Phase 1 28 participants

Study of Intravenous TCD-717 in Patients With Advanced Solid Tumors

Traslational Cancer Drugs Pharma, SL

NCT01215864

COMPLETED Phase 1 27 participants

Safety Study of IMC-18F1,to Treat Advanced Solid Tumors in Subjects That no Longer Respond to Standard Therapy

Eli Lilly and Company

NCT00782002

COMPLETED Phase 1 26 participants

Food Effect Study of Alisertib (MLN8237) in Participants With Advanced Solid Tumors or Lymphomas

Millennium Pharmaceuticals

NCT01898078

COMPLETED Phase 1 25 participants

Pharmacokinetics and Safety of Panobinostat in Patients With Advanced Solid Tumors and Various Degrees of Hepatic Function

Novartis Pharmaceuticals

NCT01007968

COMPLETED Phase 1 25 participants

A Study of AMG 820 in Subjects With Advanced Solid Tumors

AmMax Bio

NCT01444404

COMPLETED Phase 1 24 participants

A Study of CS1001 in Subjects with Advanced Solid Tumors

CStone Pharmaceuticals

NCT03744403

COMPLETED Phase 1 23 participants

Phase 1 Trial of the LSD1 Inhibitor SP-2577 (Seclidemstat) in Patients With Advanced Solid Tumors

Salarius Pharmaceuticals

NCT03895684

COMPLETED Phase 1 22 participants

First-in-human Study of M4076 in Advanced Solid Tumors (DDRiver Solid Tumors 410)

EMD Serono Research & Development Institute

NCT04882917

COMPLETED Phase 1 19 participants

Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer

R-Pharm

NCT00207090

COMPLETED Phase 1 18 participants

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ASC61in Subjects With Advanced Solid Tumors

Ascletis Pharmaceuticals Co.

NCT05287399

COMPLETED Phase 1 18 participants

Safety Study of ON 01910.Na in Combination With Irinotecan or Oxaliplatin

Traws Pharma

NCT00861328

COMPLETED Phase 1 18 participants

A Phase 1/2, Open-Label, Dose-Escalation Study of JI-101, in Patients With Advanced Solid Tumors

Jubilant Innovation

NCT00842335

COMPLETED Phase 1 17 participants

MK-2206, Paclitaxel and Trastuzumab in Treating Patients With HER2-overexpressing Solid Tumor Malignancies

University of California, San Francisco

NCT01235897

COMPLETED Phase 1 17 participants

Safety, Tolerability, and Immunoregulatory Activity of Mogamulizumab (KW-0761) in Subjects With Advanced and/or Metastatic Solid Tumors

Memorial Sloan Kettering Cancer Center

NCT02281409

COMPLETED Phase 1 16 participants

A Study of IMC-A12 Every 2 Weeks in Patients With Tumors Who No Longer Respond to Treatment or No Treatment is Available

Eli Lilly and Company

NCT00785941

COMPLETED Phase 1 14 participants

Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors

Abbott

NCT01401933

COMPLETED Phase 2 13 participants

A Rollover Study for Subjects That Have Participated in an Astellas Sponsored Linsitinib Trial

Astellas Pharma Global Development

NCT02057380

COMPLETED Phase 1 12 participants

Study of Oral Darinaparsin in Patients With Advanced Solid Tumors

Alaunos Therapeutics

NCT01139346

COMPLETED Phase 1 11 participants

Study of AMG 994 Monotherapy and AMG 994 and AMG 404 Combination Therapy in Participants With Advanced Solid Tumors

Amgen

NCT04727554

COMPLETED Phase 1 9 participants

Rollover Study for Subjects Who Have Participated in an Astellas Sponsored ASP2215 Trial

Astellas Pharma Global Development

NCT02561455

COMPLETED Phase 1 8 participants

Study of the Mass Balance of Oral FTD and TPI as Components of TAS-102 in Patients With Advanced Solid Tumors

Taiho Oncology

NCT02031055

COMPLETED Phase 1 5 participants

A Study to Look at How a Single Oral Dose of 14C-OSI-906 is Absorbed, Broken Down and Eliminated in the Body

Astellas Pharma Global Development

NCT01529684

COMPLETED Phase 1 4 participants

Study of NK012 and Carboplatin in Solid Tumors With Dose Expansion in Triple Negative Breast Cancer

Nippon Kayaku Co.

NCT01238952

COMPLETED Phase 1 3 participants

Mass Balance, Pharmacokinetics and Metabolism Study of Alisertib

Millennium Pharmaceuticals

NCT01714947

← Previous Page 3 of 3

Phase Distribution

PhaseTrial count
Phase 1 137
Phase 2 7
Phase 3 1

Top Sponsors

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Advanced Solid Tumors Trial Landscape

145 indexed Advanced Solid Tumors studies · 70 recruiting (48%).

Phase mix: 1 late (III/IV) vs 144 early (I/II).

Top sponsor: Amgen (5 trials), 9 others listed. 45 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Advanced Solid Tumors?

PlainTrial tracks 145 US clinical trials for Advanced Solid Tumors, of which 70 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Advanced Solid Tumors?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.