Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03889795 · ClinicalTrials.gov registry record · Phase 1
Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors
A Phase 1 study of Advanced Solid Tumor and Advanced Pancreatic Cancer, sponsored by Danae Hamouda, MD.
- Active
- Registry status
- Phase 1
- Development phase
- 15
- Enrollment target
- 1
- Study location
NCT03889795: Active Phase 1 study of Advanced Solid Tumor and Advanced Pancreatic Cancer, sponsored by Danae Hamouda, MD.
NCT03889795 is a Phase 1 study of Advanced Solid Tumor and Advanced Pancreatic Cancer that is active but no longer recruiting, run by Danae Hamouda, MD. The registered enrollment target is 15 participants, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03889795, a Phase 1 study of Advanced Solid Tumor and Advanced Pancreatic Cancer, is active but no longer recruiting, sponsored by Danae Hamouda, MD.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 15 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression on established standard therapy, will be enrolled in this trial.
Primary Outcome
Occurrence of any ≥ Grade 3 toxicity encountered within the four weeks following the administration of C3, regardless of attribution
Conditions Studied
Interventions
- DRUG Metformin
- DRUG Simvastatin
- DRUG Digoxin
Study Locations (1)
Ohio
- University of Toledo, Eleanor N. Dana Cancer Center - Toledo
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2019-06-05 |
| Est. Completion | 2027-12-30 |
| Phase | Phase 1 |
What the registry record for NCT03889795 still lists
NCT03889795 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 193-participant average among 189 other Advanced Solid Tumor trials with a reported enrollment target (92% lower).
The record links to 2 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 3 interventions - of which Metformin is the first listed.
NCT03889795 reports a single indexed study location in Ohio.
Frequently Asked Questions
What is clinical trial NCT03889795 about?
NCT03889795 is a clinical study titled "Phase IB Metformin, Digoxin, Simvastatin in Solid Tumors". This is a single-center trial in subjects with pancreatic cancer and other advanced solid tumors. It is an open-label, single arm dose escalation Phase IB trial with subjects accrued in a 3 subject dose escalation cohort. Subjects with treated advanced solid tumors, and showing disease progression o...
What is the current status of trial NCT03889795?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 15 participants. The study started on 2019-06-05. Estimated completion is 2027-12-30.
What conditions does trial NCT03889795 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Advanced Pancreatic Cancer.
What interventions are being tested in trial NCT03889795?
The interventions under investigation include: Metformin (DRUG), Simvastatin (DRUG), Digoxin (DRUG).
Who is sponsoring clinical trial NCT03889795?
This trial is sponsored by Danae Hamouda, MD, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03889795 being conducted?
This trial has 1 study location across Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Advanced Solid Tumor
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03889795's enrollment target sits among peer trials
15 184th of 189 higher than 2 of 189 other Advanced Solid Tumor trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Advanced Solid Tumor trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
PM14 Administered Intravenously to Patients with Advanced Solid Tumors
RECRUITING · Phase 1
-
A Study of EP0031 in Patients With Advanced RET-altered Malignancies
RECRUITING · Phase 1
-
Study of AVZO-021 in Patients With Advanced Solid Tumors
RECRUITING · Phase 1
-
A First-in-Human Study of YL217 in Patients With Advanced Solid Tumors
RECRUITING · Phase 1
-
Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors
RECRUITING · Phase 1
-
Phase I Study of Tolododekin Alfa (ANK-101) in Advanced Solid Tumors
RECRUITING · Phase 1
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT01889381 · 15 participants · Phase 2
Human Craniomaxillofacial Allotransplantation
- NCT02530073 · 15 participants · NA
Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) for CDH
- NCT02535936 · 15 participants · NA
Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
- NCT02918474 · 15 participants · NA
Decision Making Tool in Supporting Decision Making in Contralateral Prophylactic Mastectomy in Patients With Newly Diagnosed Breast Cancer
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI