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Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET
NCT03993873 · View on ClinicalTrials.gov ↗
Study Summary
A phase 1/2, first-in-human, open-label study of the safety, tolerability, PK, and efficacy of the novel MET/CSF1R/SRC inhibitor TPX-0022 in adult subjects with advanced or metastatic NSCLC, Gastric Cancer, or solid tumors harboring genetic alterations in MET. (SHIELD-I)
Conditions Studied
Interventions
- DRUG elzovantinib (TPX-0022)
Study Locations (20)
Other
- Local Institution - 4201 — Lyon
- Local Institution - 6304 — Seoul
- Local Institution - 6303 — Seoul
- Local Institution - 6302 — Seoul
California
- Local Institution - 2102 — La Jolla
- Local Institution - 2108 — Orange
Massachusetts
- Local Institution - 2107 — Boston
- Local Institution - 2109 — Boston
Michigan
- Local Institution - 2106 — Ann Arbor
- Local Institution - 2113 — Detroit
Val-de-Marne
- Local Institution - 4203 — Saint-Mandé
- Local Institution - 4204 — Villejuif
Colorado
- Local Institution - 2105 — Denver
Illinois
- Local Institution - 2111 — Chicago
Missouri
- Local Institution - 2103 — St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 95 participants |
| Start Date | 2019-09-05 |
| Est. Completion | 2027-03-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT03993873
The ClinicalTrials.gov registry entry for NCT03993873 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 95 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Turning Point Therapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 3 conditions, with Advanced Solid Tumor appearing as the primary indexed condition, and to 1 intervention — of which elzovantinib (TPX-0022) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT03993873 reports 20 study locations spanning 13 distinct geographic areas — top geographies include Other, California, Massachusetts. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT03993873 about?
NCT03993873 is a clinical study titled "Study of TPX-0022 in Patients With Advanced NSCLC, Gastric Cancer or Solid Tumors Harboring Genetic Alterations in MET". A phase 1/2, first-in-human, open-label study of the safety, tolerability, PK, and efficacy of the novel MET/CSF1R/SRC inhibitor TPX-0022 in adult subjects with advanced or metastatic NSCLC, Gastric Cancer, or solid tumors harboring genetic alterations in MET. (SHIELD-I)
What is the current status of trial NCT03993873?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 95 participants. The study started on 2019-09-05. Estimated completion is 2027-03-03.
What conditions does trial NCT03993873 study?
This clinical trial studies the following conditions: Advanced Solid Tumor, Metastatic Solid Tumors, MET Gene Alterations. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT03993873?
The interventions under investigation include: elzovantinib (TPX-0022) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT03993873?
This trial is sponsored by Turning Point Therapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT03993873 being conducted?
This trial has 20 study locations across California, Colorado, Illinois, Massachusetts, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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