Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 1

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

NCT05270213 · View on ClinicalTrials.gov ↗

Study Summary

RBS2418 (investigational product) is a specific immune modulator, working through ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1), designed to lead to anti-tumor immunity by increasing endogenous 2'-3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) and adenosine triphosphate (ATP levels) and reducing adenosine production in the tumors. RBS2418 has the potential to be an important therapeutic option for subjects both as monotherapy and in combination with other cancer treatments including monotherapy and in combination with other cancer treatments including immunotherapy or chemotherapy. This study is an open-label, multi-site Phase 1a/1b study of RBS2418, a selective ENPP1 inhibitor, in combination with pembrolizumab or other approved anticancer therapies or as a monotherapy in subjects with advanced unresectable, recurrent or metastatic tumors. The phase 1a (dose escalation phase) has been completed. The Phase 1b expansion phase of the study has been increased in size and scope.

Conditions Studied

Interventions

  • DRUG Pembrolizumab
  • DRUG RBS2418
  • DRUG Other approved anti-cancer therapy

Study Locations (14)

Arizona

  • Honor Health Research Institute — Scottsdale
  • University of Arizona — Tucson

California

  • Stanford Cancer Institute — Palo Alto
  • UCLA Hematology/Oncology - Santa Monica — Santa Monica

Maryland

  • Johns Hopkins Sidney Kimmel Comprehensive Cancer Center — Baltimore
  • American Oncology Partners of Maryland — Bethesda

Delaware

  • Christiana Care Health Services — Newark

Kentucky

  • Norton Cancer Institute — Louisville

Louisiana

  • Ochsner Clinic Foundation — New Orleans

New York

  • Ichan School of Medicine at Mount Sinai — New York

North Carolina

  • Carolina BioOncology Institute — Huntersville

Trial Details

FieldValue
Enrollment Target 164 participants
Start Date 2022-07-11
Est. Completion 2027-12
Phase Phase 1

Sponsor

Riboscience

3 total trials

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05270213

The ClinicalTrials.gov registry entry for NCT05270213 describes a study currently listed as recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 164 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Riboscience, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Advanced Cancer appearing as the primary indexed condition, and to 3 interventions — of which Pembrolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05270213 reports 14 study locations spanning 11 distinct geographic areas — top geographies include Arizona, California, Maryland. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05270213 about?

NCT05270213 is a clinical study titled "Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors". RBS2418 (investigational product) is a specific immune modulator, working through ectonucleotide pyrophosphatase/phosphodiesterase I (ENPP1), designed to lead to anti-tumor immunity by increasing endogenous 2'-3'-cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) and adenosine triphospha...

What is the current status of trial NCT05270213?

This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 164 participants. The study started on 2022-07-11. Estimated completion is 2027-12.

What conditions does trial NCT05270213 study?

This clinical trial studies the following conditions: Advanced Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05270213?

The interventions under investigation include: Pembrolizumab (DRUG), RBS2418 (DRUG), Other approved anti-cancer therapy (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05270213?

This trial is sponsored by Riboscience, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05270213 being conducted?

This trial has 14 study locations across Arizona, California, Delaware, Kentucky, Louisiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial