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A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome
NCT00391872 · View on ClinicalTrials.gov ↗
Study Summary
Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progress or the imminent threat of a heart attack. ACS is usually caused by the formation of a blood clot in an artery that partially or totally blocks the blood supply to a portion of the heart muscle. Ticagrelor will be compared with clopidogrel to determine which drug, when either is used in conjunction with aspirin, is better at reducing deaths from vascular causes, future heart attacks and/or strokes in patients with ACS.
Conditions Studied
Interventions
- DRUG Clopidogrel
- DRUG Ticagrelor
Study Locations (20)
California
- Research Site — Bakersfield
- Research Site — Beverly Hills
- Research Site — Burbank
- Research Site — Healdsburg
- Research Site — Los Angeles
- Research Site — Roseville
- Research Site — Sacramento
- Research Site — San Diego
- Research Site — Torrance
Alabama
- Research Site — Birmingham
- Research Site — Huntsville
- Research Site — Mobile
Connecticut
- Research Site — Danbury
- Research Site — Hartford
Florida
- Research Site — Atlantis
- Research Site — Daytona Beach
Arizona
- Research Site — Tucson
Colorado
- Research Site — Fort Collins
Delaware
- Research Site — Newark
District of Columbia
- Research Site — Washington D.C.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 18,624 participants |
| Start Date | 2006-10 |
| Est. Completion | 2009-03 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00391872
The ClinicalTrials.gov registry entry for NCT00391872 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 18,624 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is AstraZeneca, which has 1,053 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Acute Coronary Syndrome appearing as the primary indexed condition, and to 2 interventions — of which Clopidogrel is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00391872 reports 20 study locations spanning 8 distinct geographic areas — top geographies include California, Alabama, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00391872 about?
NCT00391872 is a clinical study titled "A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome". Ticagrelor is a new, reversible binding, anti-platelet medication. Anti-platelet medications work to prevent the formation of blood clots. Ticagrelor is being developed as a treatment for patients with acute coronary syndrome (ACS). ACS is a term that is used to describe both heart attacks in progre...
What is the current status of trial NCT00391872?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 18,624 participants. The study started on 2006-10. Estimated completion is 2009-03.
What conditions does trial NCT00391872 study?
This clinical trial studies the following conditions: Acute Coronary Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00391872?
The interventions under investigation include: Clopidogrel (DRUG), Ticagrelor (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00391872?
This trial is sponsored by AstraZeneca, which has 1,053 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00391872 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Connecticut. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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