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ACTIVE NOT RECRUITING Phase 3

A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome

NCT05754957 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular \[CV\] death, myocardial infarction \[MI\], and ischemic stroke).

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG Milvexian

Study Locations (20)

California

  • Bakersfield Memorial Hospital — Bakersfield
  • Mission Cardiovascular Research Institute — Fremont
  • Radin Cardiovascular Medical Group — Newport Beach
  • Valley Clinical Trials, Inc. — Northridge
  • Stanford University School of Medicine — Palo Alto
  • VA Palo Alto Healthcare System — Palo Alto
  • Huntington Hospital — Pasadena
  • The Cardiovascular Center — Redding
  • University Of California San Diego — San Diego
  • San Diego Cardiac Center — San Diego
  • VA San Diego Health Care System — San Diego

Alabama

  • Advanced Cardiovascular, LLC — Alexander City
  • SORRA Research — Birmingham
  • Ascension St. Vincent's Health System — Birmingham
  • IMC-Diagnostic and Medical Clinic — Mobile
  • Cardiology Associates of Mobile Inc — Mobile

Arizona

  • Mercy Gilbert Medical Center — Gilbert
  • Valleywise Health Medical Center — Phoenix
  • HonorHealth Neurology — Scottsdale

Arkansas

  • Arkansas Heart Hospital — Little Rock

Trial Details

FieldValue
Enrollment Target 14,194 participants
Start Date 2023-04-07
Est. Completion 2026-10-19
Phase Phase 3

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05754957

The ClinicalTrials.gov registry entry for NCT05754957 describes a study currently listed as active not recruiting. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 14,194 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Acute Coronary Syndrome appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05754957 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05754957 about?

NCT05754957 is a clinical study titled "A Study of Milvexian in Participants After a Recent Acute Coronary Syndrome". The purpose of this study is to evaluate that milvexian is superior to placebo, in addition to standard-of-care, in reducing the risk of major adverse cardiovascular event (MACE) (the composite of cardiovascular \[CV\] death, myocardial infarction \[MI\], and ischemic stroke).

What is the current status of trial NCT05754957?

This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 14,194 participants. The study started on 2023-04-07. Estimated completion is 2026-10-19.

What conditions does trial NCT05754957 study?

This clinical trial studies the following conditions: Acute Coronary Syndrome. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05754957?

The interventions under investigation include: Placebo (OTHER), Milvexian (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05754957?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05754957 being conducted?

This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial