Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 25 of 30

COMPLETED Phase 1

Sensitivity to Intravenous Nicotine: Genetic Moderators

NCT00969137

COMPLETED

Endometrial Effects of Metformin Action in Women With Polycystic Ovarian Syndrome (PCOS)

NCT01070160

COMPLETED NA

Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects

NCT00935493

COMPLETED NA

Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates

NCT01050660

COMPLETED NA

Hormones and Physical Exercise (HOPE) Study

NCT02056067

COMPLETED

Imaging of Cannabinoid 1 Receptors Using [11C]OMAR and PET

NCT01719497

TERMINATED Phase 2

Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD): The Role of Biomarkers in Predicting a Response to Therapy

NCT00920309

COMPLETED Phase 1

Vorinostat in Combination With Palliative Radiotherapy for Patients With Non-Small Cell Lung Cancer

NCT00821951

COMPLETED

Registry of Pregnancies Conceived Following Exposure to Ovulation Stimulation Medications

NCT00902382

COMPLETED NA

Pilot Study of a Raltegravir Based NRTI Sparing Regimen

NCT00814879

COMPLETED Phase 3

Women's Activity and Lifestyle Study in Connecticut

NCT02107066

COMPLETED Phase 1

Combination of Lenalidomide and Autologous Mature Dendritic Cells Pulsed With KRN7000 in Myeloma

NCT00698776

COMPLETED Phase 2

Concurrent Alcohol and Smoking Treatment: Effects on Alcohol Relapse Risk

NCT00861146

COMPLETED NA

Changing Lifestyles for Better Health

NCT00848757

COMPLETED NA

Buprenorphine/Raltegravir Pharmacokinetic Interaction Study

NCT00858962

COMPLETED Early Phase 1

Effects of Salvinorin A in Healthy Controls

NCT00700596

COMPLETED Early Phase 1

Effects of Delta-9-THC and Iomazenil in Healthy Humans

NCT00982982

COMPLETED Phase 2

Cannabidiol Treatment of Cognitive Dysfunction in Schizophrenia

NCT00588731

COMPLETED Phase 2

Study of Sorafenib and Transarterial Chemoembolization (TACE) to Treat Hepatocellular Carcinoma

NCT00844883

COMPLETED Phase 2

Investigation of Naltrexone for Pathological Gambling

NCT01057862

COMPLETED Phase 2

Ketamine Infusion for Obsessive-Compulsive Disorder

NCT01349231

COMPLETED NA

Mindfulness Training for Smoking Cessation

NCT01144689

COMPLETED Phase 3

Pregnancy in Polycystic Ovary Syndrome II

NCT00719186

TERMINATED NA

Doxorubicin Beads in Treating Patients With Unresectable Liver Metastases From Neuroendocrine Tumors

NCT00730483

COMPLETED Phase 3

Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).

NCT00744055

COMPLETED

Chronic Alcohol and Brain Stress Circuit Response

NCT01031264

COMPLETED NA

Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence

NCT00923923

TERMINATED Phase 1

Vorinostat and Pegylated Liposomal Doxorubicin in Relapsed or Refractory Lymphomas

NCT00785798

COMPLETED NA

Rehabilitation of Patients With COPD Using Electrical Muscle Stimulation

NCT01799330

COMPLETED NA

Pilot Trial of Naltrexone for Obesity in Women With Schizophrenia

NCT00793780

COMPLETED

The Impact of Pancreatic Islet Cell Allotransplantation on Cognitive Function in Type 1 Diabetes Mellitus

NCT00590876

COMPLETED Phase 2

A Trial of Negative Ion Generation Versus Light-Emitting Diode Phototherapy for Seasonal Affective Disorder (SAD)

NCT00809523

COMPLETED Phase 1

Study of the Weekly Oral RAD001 in Combination With Oral Topotecan in Patients With Advanced or Recurrent Endometrial Cancers

NCT00703807

COMPLETED Phase 1

HDAC Inhibitor Vorinostat (SAHA) With Capecitabine (Xeloda) Using a New Weekly Dose Regimen for Advanced Breast Cancer

NCT00719875

COMPLETED NA

Treatment of Obesity and Binge Eating: Behavioral Weight Loss Versus Stepped Care

NCT00829283

COMPLETED NA

The Impact of Active Nurse Participation on Adenoma Detection During Routine Colonoscopy

NCT00859625

COMPLETED Phase 2

Modeling Stress-precipitated Smoking Behavior for Medication Development

NCT00773357

COMPLETED Early Phase 1

Biological Clock Dysfunction in Optic Nerve Hypoplasia

NCT00825591

TERMINATED Phase 2

Domperidone in Refractory Gastroparesis

NCT00760461

COMPLETED Early Phase 1

Dronabinol Interactions With Cognitive Enhancing Drug in Humans

NCT00842985

COMPLETED NA

Transitions: Linkages From Jail To Community

NCT00841711

COMPLETED NA

Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department

NCT00913770

COMPLETED NA

Implementation of Practice Standards for ECG Monitoring

NCT01269736

COMPLETED NA

Health Benefits of Vitamin D and Calcium in Women With PCOS (Polycystic Ovarian Syndrome)

NCT00743574

COMPLETED NA

Transvaginal Appendectomy

NCT00806429

COMPLETED NA

The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects

NCT01600885

COMPLETED NA

Chronic Pain and Opioid Dependence Assessment and Treatment

NCT00727675

TERMINATED

Impact of Oral Contraceptives on GABA and Neurosteroids

NCT00656318

COMPLETED Phase 4

Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence

NCT00555425

COMPLETED Phase 4

Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women

NCT00628771

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.