Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 26 of 30

COMPLETED

The Prevalence of HIV Drug Resistance and Transmission Risk in Opioid Agonist Treatment

NCT00857350

COMPLETED Phase 2

FOLFOX With Bevacizumab in Metastatic or Unresectable Gastroesophageal and Gastric Cancer

NCT00673673

COMPLETED

Functional MRI of Stress in Obesity

NCT01719484

COMPLETED Phase 3

TEENCOPE: An Internet Coping Skills Training Program for Teens With Type 1 Diabetes

NCT00684658

COMPLETED Phase 1

Pharmacotherapy & CM for Opioid and Cocaine Dependence

NCT00838981

COMPLETED NA

Randomized, Controlled, Double Blind Trial of Eszopiclone for Insomnia Associated With Schizophrenia

NCT00645944

COMPLETED Phase 2

Modification of Cognitive Processing Therapy (CPT-C) for PTSD and Alcohol Dependence

NCT00639288

COMPLETED Phase 2

Ziprasidone in the Psychosis Prodrome

NCT00635700

COMPLETED Early Phase 1

Cannabinoids, Neural Synchrony, and Information Processing

NCT00708994

COMPLETED Phase 4

Naltrexone for Heavy Drinking in Young Adults

NCT00568958

COMPLETED Early Phase 1

Compromised Microcirculation in Women With Polycystic Ovary Syndrome

NCT00757185

TERMINATED Phase 1

Rapamycin for Prevention of Chronic Graft-Versus-Host Disease

NCT00623012

COMPLETED Phase 1

Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects

NCT00700076

COMPLETED NA

Basic Research Study to Examine the Relation Between Muscle Insulin Resistance and Lipid Production in the Liver.

NCT02196051

COMPLETED NA

Positive Lifestyles Using Safety

NCT00836290

COMPLETED Phase 2

The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse

NCT00773422

COMPLETED NA

Women With Cancer: An Exercise Study to Promote Health

NCT01102985

COMPLETED NA

Stress Reduction to Reduce Risk for Arrhythmia in ICD Patients (The RISTA Study)

NCT00627263

COMPLETED Phase 2

Investigation of Efficacy and Safety of Botulinum Toxin A (Botox-Allergan Inc) in Migraine Headaches

NCT00660192

COMPLETED Phase 2

Memantine Treatment Study of Pathological Gambling

NCT00585169

COMPLETED Phase 1

Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) Antagonism

NCT02675530

COMPLETED Phase 2

Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse

NCT00809835

COMPLETED Phase 4

Evaluating the Effectiveness of Sertraline in Treating Women With Premenstrual Dysphoric Disorder

NCT00536198

COMPLETED Phase 1

Computer-Based Training in Cognitive Behavior Therapy

NCT00350610

COMPLETED

The Role of Stress in Self-Control, Coping, and Emotion Regulation

NCT01554501

COMPLETED

Cortical GABA Concentrations in Insomnia

NCT00765752

COMPLETED Early Phase 1

Sirolimus, Tacrolimus and Short Course Methotrexate for Prevention of Acute GVHD in Recipients of Mismatched Unrelated Donor Allogeneic Stem Cell Transplantation

NCT00612274

COMPLETED

Racial Differences in Orthostatic Tolerance

NCT00844181

COMPLETED NA

Bilateral Repetitive Transcranial Magnetic Stimulation for Auditory Hallucinations Original Study

NCT00567281

COMPLETED Phase 1

Sex Differences in Progesterone Effects on Responses to Stress and Drug Cues

NCT00585520

COMPLETED NA

Cocaine Withdrawal and Pharmacotherapy Response

NCT00566969

COMPLETED

Examining Heart Attacks in Young Women

NCT00597922

COMPLETED NA

Drug Counseling and Abstinent-Contingent Take-Home Buprenorphine in Malaysia

NCT00539123

COMPLETED Phase 4

Treatment of Binge Eating in Obese Patients in Primary Care

NCT00537810

COMPLETED Phase 3

Behavioral Drug and HIV Risk Reduction Counseling in Methadone Patients in China

NCT00757744

TERMINATED Phase 2

N-Acetylcysteine in Adjunct to DBT for the Treatment of Self-Injurious Behavior in BPD

NCT00539188

TERMINATED NA

Ceftriaxone in the Management of Bipolar Depression

NCT00566111

COMPLETED Early Phase 1

Pharmacogenetics of Cannabinoid Response

NCT00678730

COMPLETED Phase 1

Cannabinoid Receptor Function & Alcoholism

NCT00624715

COMPLETED Phase 1

Message Framing for Telephone Quitline Callers

NCT00589277

COMPLETED NA

Varenicline and Nicotine Interactions in Humans (VA)

NCT00606892

COMPLETED Phase 4

Study of Behavioral Weight Loss Therapy for Obesity and Binge Eating in Monolingual Hispanic Persons

NCT00516919

COMPLETED Early Phase 1

GABA (Gamma Amino Butyric Acid) Medication for Tobacco

NCT00644137

COMPLETED Early Phase 1

Early Versus Delayed Routine HIV Testing in Connecticut Jails

NCT00624247

COMPLETED Phase 3

Mecamylamine for the Treatment of Patients With Depression and Alcohol Dependence

NCT00563797

COMPLETED NA

An Integrated Substance Abuse-Domestic Violence (SADV) Treatment Outcome Study

NCT07140276

COMPLETED NA

Daily Exposure Monitoring to Prevent Hearing Loss

NCT01714375

COMPLETED Phase 2

Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome

NCT00529308

COMPLETED Phase 1

Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers

NCT00502216

COMPLETED Phase 2

Efficacy of Levetiracetam in Cocaine-Abusing Methadone Maintained Patients

NCT00577005

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.