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NCT00923923 · ClinicalTrials.gov registry record · NA
Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 57
- Enrollment target
NCT00923923: Completed NA study, sponsored by Yale University.
NCT00923923 is a NA study that has completed, run by Yale University. The registered enrollment target is 57 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00923923, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 57 participants
- Enrollment target
Study Summary
Method: This study is designed as an accompaniment to an already funded study - a 12-week treatment trial with prazosin for patients with PTSD and AD. The study design will consist of III phases. In phase I, all subjects will participate in three laboratory sessions to determine their reactivity to stress. Stress reactivity will be measured using: traumatic experiences, stressful non-trauma experiences and neutral experiences, presented randomly. Laboratory sessions will be conducted in an outpatient setting. Phase II is a randomized clinical trial evaluating prazosin versus placebo for 12 weeks in a double-blind, controlled fashion in an outpatient setting. The treatment will last for 12 weeks and outcomes will include symptoms of PTSD and alcohol use. In phase III, subjects will again participate in a laboratory session. This phase of the study will be conducted after at least 6 weeks of treatment while patients are on medication (prazosin or placebo). Hypotheses: Primary: The investigators hypothesize that prazosin will be more effective than placebo in reducing trauma-related stress reactivity in a laboratory paradigm, particularly anxiety, craving for alcohol, and hormonal response, in individuals with PTSD and AD. Secondary: The investigators hypothesize that stress reactivity will have a moderating effect on treatment with prazosin, such that individuals with high levels of stress reactivity will have fewer heavy drinking days, a significant reduction in PTSD symptoms, and shorter time to relapse than individuals with low levels of stress reactivity.
Interventions
- BEHAVIORAL stress
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 57 participants |
| Start Date | 2009-01 |
| Est. Completion | 2015-07 |
| Phase | NA |
What the finished NCT00923923 record still lists
NCT00923923 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 57 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which stress is the first listed.
NCT00923923 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00923923 about?
NCT00923923 is a clinical study titled "Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence". Method: This study is designed as an accompaniment to an already funded study - a 12-week treatment trial with prazosin for patients with PTSD and AD. The study design will consist of III phases. In phase I, all subjects will participate in three laboratory sessions to determine their reactivity to...
What is the current status of trial NCT00923923?
This trial is currently completed. It is a NA study. The enrollment target is 57 participants. The study started on 2009-01. Estimated completion is 2015-07.
What interventions are being tested in trial NCT00923923?
The interventions under investigation include: stress (BEHAVIORAL).
Who is sponsoring clinical trial NCT00923923?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00923923's enrollment target sits among peer trials
57 1261st of 2000 higher than 739 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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