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NCT00935493 · ClinicalTrials.gov registry record · NA
Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
A NA study, sponsored by Yale University.
- Completed
- Registry status
- NA
- Development phase
- 154
- Enrollment target
NCT00935493: Completed NA study, sponsored by Yale University.
NCT00935493 is a NA study that has completed, run by Yale University. The registered enrollment target is 154 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00935493, a NA study, has completed, sponsored by Yale University.
- COMPLETED
- Registry status
- NA
- Development phase
- 154 participants
- Enrollment target
Study Summary
This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
Primary Outcome
The primary outcome measure (PEF6\_Z) is the mean of z-scores for 6 executive function tasks (CANTAB: Spatial Working Memory, Stockings of Cambridge, Intradimensiona/Extradimensional Shift, Paired Associates Learning; Stroop Color Word Score, Trail Making Test - B). The score is composed of six component scales coded as z scores that measures cognitive functioning in which higher scores represent better cognitive functioning; therefore, the least squares means listed here represent mean outcome
Interventions
- DRUG Placebo
- DRUG Guanfacine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 154 participants |
| Start Date | 2009-06 |
| Est. Completion | 2012-08 |
| Phase | NA |
What the finished NCT00935493 record still lists
NCT00935493 is an interventional study that assigns participants to a tested intervention. The registered 154 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (89% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00935493 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00935493 about?
NCT00935493 is a clinical study titled "Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects". This proposal aims to determine whether low does of the alpha-2A-adrenoceptor agonist guanfacine can improve deficits in prefrontally-mediated cognitive functions in healthy elderly subjects.
What is the current status of trial NCT00935493?
This trial is currently completed. It is a NA study. The enrollment target is 154 participants. The study started on 2009-06. Estimated completion is 2012-08.
What interventions are being tested in trial NCT00935493?
The interventions under investigation include: Placebo (DRUG), Guanfacine (DRUG).
Who is sponsoring clinical trial NCT00935493?
This trial is sponsored by Yale University, which has 1,492 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00935493's enrollment target sits among peer trials
154 656th of 2000 higher than 1,345 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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