University of Pennsylvania

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, University of Pennsylvania sits in the top decile of US sponsors by registered trial count (#15 of 15,742 sponsors by registered trial count).

1,423 total trials 199 currently recruiting 982 completed early-phase tilt top decile by trial count

University of Pennsylvania: 1,423 sponsored US clinical trials, 199 recruiting.

University of Pennsylvania sponsors 1,423 registered US clinical trials on ClinicalTrials.gov, 199 of them currently recruiting, and 982 completed. 130 of these trials are in Phase 3-4 (later-stage) and 339 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Obesity, with 17 trials.

Top-decile sponsor footprint

University of Pennsylvania ranks in the top decile of sponsors by registered trial count (#15 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 65/100

982 of 1,090 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (90.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,423 total, page 12 of 29

COMPLETED NA

A Peer-Led Intervention to Improve Postpartum Retention in HIV Care

NCT04168008

COMPLETED

Clinical Performance of NIPT in Multiple Gestation Pregnancies

NCT04488393

TERMINATED Early Phase 1

18F-FluorThanatrace (PET/CT) in Glioblastoma

NCT04221061

COMPLETED Phase 1

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease

NCT04482179

COMPLETED Phase 1

Developing Oral LT3 Therapy for Heart Failure - HFrEF

NCT04112316

TERMINATED

Effect of PARP Inhibitors on Glomerular Filtration Rate

NCT04367467

COMPLETED NA

Ob/Gyn Residency Podcast Curriculum

NCT04933071

COMPLETED NA

Testing the Influence of Different Sugary Drink Warning Label Designs

NCT03648138

TERMINATED Phase 2

Penn Microbiome Therapy (PMT) for Severe-Clostridium Difficile Infection (CDI)

NCT03970200

COMPLETED NA

Fruits and Vegetables Incentives Study

NCT04235413

COMPLETED NA

Improving Aging in Place in Subsidized Housing

NCT04212442

TERMINATED Phase 2

Penn Microbiome Therapy for Recurrent Clostridium Difficile Infection

NCT03973697

COMPLETED NA

Lactation Achievement With Texts at Home

NCT04108533

COMPLETED Early Phase 1

Low Dose Fat-Induced Insulin Resistance

NCT03479671

COMPLETED Phase 4

Neurocognitive Benefits of a Weight Management Program

NCT04202133

COMPLETED NA

FITBIT Study on Mobility and Readmissions After Radical Cystectomy

NCT04314778

COMPLETED NA

Effect of rTMS on Anxiety

NCT03993509

COMPLETED NA

Acceptability and Efficacy of the Zemedy App for Irritable Bowel Syndrome

NCT04170686

COMPLETED

Perspectives on Prophylactic Antibiotic Use in Dermatologic Surgery

NCT04150523

COMPLETED

Antibiotic Adherence Practices in Dermatologic Surgery

NCT04117724

COMPLETED NA

Randomized Clinical Trial to Increase Physical Activity After a a Hypertensive Pregnancy

NCT04119232

COMPLETED NA

Hypnosis for Bladder Pain Syndrome

NCT04010513

TERMINATED Early Phase 1

Molecular Imaging of the Underlying Mechanism of Cardiotoxicity in Patients With Light Chain Amyloidosis Using PET/CT

NCT04105634

COMPLETED NA

Tracking and Improving Trust/Respect

NCT04392336

COMPLETED Phase 3

First Line Radiofrequency Ablation Versus Antiarrhythmic Drugs for Persistent Atrial Fibrillation Treatment (RAAFT-3)

NCT04037397

TERMINATED NA

Commensal Oral Microbiota in Head and Neck Cancer

NCT03843554

COMPLETED Phase 4

Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis C

NCT03365635

COMPLETED NA

Use of Virtual Reality for Overdose Management Educational Trainings

NCT04091659

COMPLETED NA

Nurtured in Nature

NCT04146025

COMPLETED NA

Bone Regenerative Techniques in Endodontic Microsurgery

NCT04514991

COMPLETED NA

A Randomized Trial of Behavioral Economic Approaches to Reduce Unnecessary Opioid Prescribing

NCT03825549

COMPLETED NA

Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment

NCT04073992

COMPLETED NA

Move to Improve Physical Activity in Parkinson's Disease

NCT04051151

COMPLETED Phase 2

Improving Self-care of Heart Failure Caregivers

NCT03988621

COMPLETED NA

Magnetic Stimulation to Treat VT Storm

NCT04043312

COMPLETED Phase 4

Pitocin or Oral Misoprostol for PROM IOL

NCT04028765

COMPLETED Phase 4

Rapid Initiation of Drug Treatment Engagement

NCT03908437

COMPLETED Phase 4

Use of Medication to Improve Weight Loss in Suboptimal Early Responders to Behavioral Treatment

NCT03779048

COMPLETED NA

Machine-Generated Mortality Estimates and Nudges to Promote Advance Care Planning Discussion Among Cancer Patients

NCT03984773

COMPLETED

Post-op Crowd Sourcing Health Data Via Text-messaging

NCT03532256

COMPLETED

Voices Of Individuals: Challenges and Experiences Of bvFTD

NCT04060082

COMPLETED NA

Time Restricted Eating Pilot - Bariatrics

NCT04006366

COMPLETED

Vessel Wall MR Imaging to Explore Sex-Differences of Intracranial Arterial Wall Changes After Suspected Stroke

NCT03990545

COMPLETED NA

Plan and Pledge, HIV Self-testing in South Africa

NCT03898557

COMPLETED NA

Medication Adherence and Outcomes Among Patients in United States With HIV

NCT03995745

COMPLETED NA

Using Digital Health, Financial Incentives, and Community Health Worker Support to Change Health Behavior

NCT03939793

COMPLETED Phase 1

Towards Predicting the Analgesic Response to Ibuprofen Following Third-molar Extraction

NCT03893175

COMPLETED NA

Comparative Effectiveness of Financial Incentives and Nudges to Reduce Cellphone Use While Driving Among UBI Auto Policy Holders

NCT03833219

COMPLETED

Cholate Clearance in Fontans

NCT03726229

COMPLETED NA

Evaluation of SmartSleep Technology for Improving the Efficiency and Restorative Quality of Sleep in Healthy Adults

NCT03911154

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Phase Distribution

PhaseTrial count
Phase 1 182
Phase 2 157
Phase 3 43
Phase 4 87

What is open in the University of Pennsylvania pipeline

199 recruiting of 1,423 indexed (14% open); 982 completed (69%).

Phase mix: 130 late (III/IV) vs 339 early (I/II) (early-phase heavy).

Top condition: Obesity (17 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

University of Pennsylvania: open-pipeline peers nationwide

Peers matched on 1,423 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

University of Pennsylvania sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 0%5%10%15%20% Total trials Recruiting share University of PennsylvaniaJohns Hopkins UniversityNovartis PharmaceuticalsYale UniversityGlaxoSmithKlineSeattle Institute for Biomedical and Clinical ResearchUniversity of Illinois at Urbana-ChampaignJohns Hopkins Bloomberg School of Public HealthMilton S. Hershey Medical Center
University of Pennsylvania sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

University of Pennsylvania sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,423 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this University of Pennsylvania page

1,423 registered trials is a research-attention snapshot, not an endorsement of University of Pennsylvania or any single study.

  • 199 of University of Pennsylvania's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Obesity is the condition University of Pennsylvania studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Obesity trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. University of Pennsylvania pipeline card: 1,423 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.