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NCT03993509 · ClinicalTrials.gov registry record · NA
Effect of rTMS on Anxiety
A NA study of Anxiety and Fear, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 68
- Enrollment target
- 1
- Study location
NCT03993509: Completed NA study of Anxiety and Fear, sponsored by University of Pennsylvania.
NCT03993509 is a NA study of Anxiety and Fear that has completed, run by University of Pennsylvania. The registered enrollment target is 68 participants, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03993509, a NA study of Anxiety and Fear, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 68 participants
- Enrollment target
- 1
- Study location
Study Summary
Given the overall lack of treatment adherence/efficacy, side effects of drugs, and the substantial burden of anxiety disorders on the individual and on the national healthcare system, there is a critical need for mechanistic research into the CNS mechanisms that underlie these disorders. Accordingly, the objective of this grant is to use noninvasive neuromodulation to causally identify the key neural mechanisms that mediate the cognitive symptoms of anxiety. This project is relevant to public health because it has the potential to lead to novel repetitive transcranial magnetic stimulation treatments for pathological anxiety.
Primary Outcome
Electromyography Facial electromyography (EMG) startle responses were recorded from the left orbicularis oculi muscle at 2000 Hz using a Biopac MP160 unit (Biopac; Goleta, CA) via 15 × 20 mm hydrogel coated vinyl electrodes (Rhythmlink #DECUS10026; Columbia, SC). Startle EMG was bandpass filtered from 30 to 300 Hz, rectified, and smoothed using a 20-ms sliding window. Startle responses were scored as the peak (max during the 20 ms to 120 ms post-noise window) - the baseline (50 ms pre-noise win
Conditions Studied
Interventions
- DEVICE rTMS to the right dlPFC
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2019-10-30 |
| Est. Completion | 2022-11-23 |
| Phase | NA |
What the finished NCT03993509 record still lists
NCT03993509 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 68 participants, a relatively small participant target, below the 440-participant average among 364 other Anxiety trials with a reported enrollment target (85% lower).
The record links to 3 conditions, with Anxiety appearing as the primary indexed condition, and to 1 intervention - of which rTMS to the right dlPFC is the first listed.
NCT03993509 reports a single indexed study location in Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT03993509 about?
NCT03993509 is a clinical study titled "Effect of rTMS on Anxiety". Given the overall lack of treatment adherence/efficacy, side effects of drugs, and the substantial burden of anxiety disorders on the individual and on the national healthcare system, there is a critical need for mechanistic research into the CNS mechanisms that underlie these disorders. Accordingly...
What is the current status of trial NCT03993509?
This trial is currently completed. It is a NA study. The enrollment target is 68 participants. The study started on 2019-10-30. Estimated completion is 2022-11-23.
What conditions does trial NCT03993509 study?
This clinical trial studies the following conditions: Anxiety, Fear, Anxiety and Fear.
What interventions are being tested in trial NCT03993509?
The interventions under investigation include: rTMS to the right dlPFC (DEVICE).
Who is sponsoring clinical trial NCT03993509?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03993509 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anxiety
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03993509's enrollment target sits among peer trials
68 218th of 364 higher than 145 of 364 other Anxiety trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anxiety trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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