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NCT04073992 · ClinicalTrials.gov registry record · NA
Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment
A NA study of Insomnia Chronic, sponsored by University of Pennsylvania.
- Completed
- Registry status
- NA
- Development phase
- 9
- Enrollment target
- 1
- Study location
NCT04073992 is a NA study of Insomnia Chronic that has completed, run by University of Pennsylvania. The registered enrollment target is 9 participants, below the 118-participant average among 16 other Insomnia Chronic trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state.
The verdict
NCT04073992, a NA study of Insomnia Chronic, has completed, sponsored by University of Pennsylvania.
- COMPLETED
- Registry status
- NA
- Development phase
- 9 participants
- Enrollment target
- 1
- Study location
Study Summary
The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years. The purpose of this study is to examine whether treatment of insomnia with cognitive behavioral therapy (CBT-I) is associated with a decrease in dementia biomarkers found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning. This will be followed by 8 weeks of treatment with CBT-I and then repeat CSF sampling.
Conditions Studied
Interventions
- BEHAVIORAL cognitive behavioral treatment of insomnia
Study Locations (1)
Pennsylvania
- University of Pennsylvania - Philadelphia
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2019-09-01 |
| Est. Completion | 2022-12-30 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04073992
The ClinicalTrials.gov registry entry for NCT04073992 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 9 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 118-participant average among 16 other Insomnia Chronic trials with a reported enrollment target (92% lower). The listed sponsor is University of Pennsylvania, which has 1,423 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Insomnia Chronic appearing as the primary indexed condition, and to 1 intervention - of which cognitive behavioral treatment of insomnia is the first listed.
NCT04073992 reports 1 study location spanning 1 distinct geographic area - top geographies include Pennsylvania.
Frequently Asked Questions
What is clinical trial NCT04073992 about?
NCT04073992 is a clinical study titled "Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment". The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasin...
What is the current status of trial NCT04073992?
This trial is currently completed. It is a NA study. The enrollment target is 9 participants. The study started on 2019-09-01. Estimated completion is 2022-12-30.
What conditions does trial NCT04073992 study?
This clinical trial studies the following conditions: Insomnia Chronic.
What interventions are being tested in trial NCT04073992?
The interventions under investigation include: cognitive behavioral treatment of insomnia (BEHAVIORAL).
Who is sponsoring clinical trial NCT04073992?
This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04073992 being conducted?
This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Read our methodology - how this data is sourced, computed, and verified.
Related
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