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NCT04073992 · ClinicalTrials.gov registry record · NA

Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment

A NA study of Insomnia Chronic, sponsored by University of Pennsylvania.

Completed
Registry status
NA
Development phase
9
Enrollment target
1
Study location

NCT04073992: Completed NA study of Insomnia Chronic, sponsored by University of Pennsylvania.

NCT04073992 is a NA study of Insomnia Chronic that has completed, run by University of Pennsylvania. The registered enrollment target is 9 participants, below the 118-participant average among 16 other Insomnia Chronic trials with a reported enrollment target (92% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04073992, a NA study of Insomnia Chronic, has completed, sponsored by University of Pennsylvania.

COMPLETED
Registry status
NA
Development phase
9 participants
Enrollment target
1
Study location

Study Summary

The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasing vulnerability to dementia. Longitudinal studies have found that sleep disturbance often precedes and increases risk for dementia by several years. The purpose of this study is to examine whether treatment of insomnia with cognitive behavioral therapy (CBT-I) is associated with a decrease in dementia biomarkers found in cerebrospinal fluid (CSF). Fifteen adults age 30-50 with chronic insomnia will undergo overnight polysomnography and CSF sampling in the morning. This will be followed by 8 weeks of treatment with CBT-I and then repeat CSF sampling.

Primary Outcome

CSF levels of the proteins tau and beta amyloid

Conditions Studied

Insomnia Chronic

Interventions

  • BEHAVIORAL cognitive behavioral treatment of insomnia

Study Locations (1)

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 9 participants
Start Date 2019-09-01
Est. Completion 2022-12-30
Phase NA
University of Pennsylvania

1,423 total trials

What the finished NCT04073992 record still lists

NCT04073992 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 118-participant average among 16 other Insomnia Chronic trials with a reported enrollment target (92% lower).

The record links to 1 condition, with Insomnia Chronic appearing as the primary indexed condition, and to 1 intervention - of which cognitive behavioral treatment of insomnia is the first listed.

NCT04073992 reports a single indexed study location in Pennsylvania.

Frequently Asked Questions

What is clinical trial NCT04073992 about?

NCT04073992 is a clinical study titled "Chronic Insomnia and CSF Markers of Dementia - Effects of Treatment". The longstanding view has been that insomnia, and other forms of sleep disturbance, emerge as a consequence of dementia and are the result of progressive neuronal damage. However, there is growing evidence that the direction of causation may go both ways, with sleep disturbance potentially increasin...

What is the current status of trial NCT04073992?

This trial is currently completed. It is a NA study. The enrollment target is 9 participants. The study started on 2019-09-01. Estimated completion is 2022-12-30.

What conditions does trial NCT04073992 study?

This clinical trial studies the following conditions: Insomnia Chronic.

What interventions are being tested in trial NCT04073992?

The interventions under investigation include: cognitive behavioral treatment of insomnia (BEHAVIORAL).

Who is sponsoring clinical trial NCT04073992?

This trial is sponsored by University of Pennsylvania, which has 1,423 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04073992 being conducted?

This trial has 1 study location across Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Insomnia Chronic

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04073992's enrollment target sits among peer trials

9 17th of 16 the lowest of 16 other Insomnia Chronic trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Insomnia Chronic trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT04073992, the US trial registry maintained by the National Library of Medicine. NCT04073992 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.