Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00418457 · ClinicalTrials.gov registry record · Phase 3
Regional Anesthesia and Breast Cancer Recurrence
A Phase 3 study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- Phase 3
- Development phase
- 2,108
- Enrollment target
NCT00418457: Completed Phase 3 study, sponsored by The Cleveland Clinic.
NCT00418457 is a Phase 3 study that has completed, run by The Cleveland Clinic. The registered enrollment target is 2,108 participants, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (173% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00418457, a Phase 3 study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- Phase 3
- Development phase
- 2,108 participants
- Enrollment target
Study Summary
In this multi-center trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to thoracic epidural or paravertebral anesthesia/analgesia, or to general anesthesia and morphine analgesia. Participants will be followed for up to 10 years to determine the rate of cancer recurrence or metastasis.
Primary Outcome
time to breast cancer recurrence from the end of surgery.
Interventions
- DRUG General anesthesia and opioids
- DRUG Regional analgesia and propofol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,108 participants |
| Start Date | 2007-01 |
| Est. Completion | 2019-12 |
| Phase | Phase 3 |
What the finished NCT00418457 record still lists
NCT00418457 is an interventional study that assigns participants to a tested intervention. Its 2,108 participants enrollment target places it among the larger protocols in the corpus, above the 772-participant average among 15,282 other Phase 3 trials with a reported enrollment target (173% higher).
The record links to 0 conditions, and to 2 interventions - of which General anesthesia and opioids is the first listed.
NCT00418457 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00418457 about?
NCT00418457 is a clinical study titled "Regional Anesthesia and Breast Cancer Recurrence". In this multi-center trial, Stage 1-3 patients having mastectomies or isolated lumpectomy with axillary node dissection will be randomly assigned to thoracic epidural or paravertebral anesthesia/analgesia, or to general anesthesia and morphine analgesia. Participants will be followed for up to 10 ye...
What is the current status of trial NCT00418457?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 2,108 participants. The study started on 2007-01. Estimated completion is 2019-12.
What interventions are being tested in trial NCT00418457?
The interventions under investigation include: General anesthesia and opioids (DRUG), Regional analgesia and propofol (DRUG).
Who is sponsoring clinical trial NCT00418457?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00418457's enrollment target sits among peer trials
2,108 98th of 2000 higher than 1,903 of 2,000 other Phase 3 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 3 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT05967273 · 2,106 participants · NA
CirrhosisRx CDS System
- NCT04649242 · 2,100 participants · Phase 3
Randomized Study in Children and Adolescents With Migraine: Acute Treatment
- NCT05206331 · 2,100 participants · Phase 4
CEM to Reduce Biopsy Rates for Less Than Highly Suspicious Breast Abnormalities: a Prospective Study
- NCT05270499 · 2,100 participants
Aveir VR Real-World Evidence Post-Approval Study
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia