The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 12 of 14

COMPLETED NA

Virtual Hypertension Clinic

NCT01167920

COMPLETED

Randomized Trial of Alerts in Patients Demonstrating a "Triple Low"

NCT00998894

COMPLETED Phase 4

Does Treximet Improve Productivity and Patient Satisfaction Due to Sustained Response and Consistency of Response?

NCT01086358

COMPLETED NA

Capsule Endoscopy for Post-Ablation Esophageal Lesion Assessment

NCT00990782

COMPLETED NA

Lidocaine 5% Patch (Lidoderm) for the Prevention of Acute and Chest Pain Following Robotic Valve Surgery

NCT03120351

COMPLETED

The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras

NCT01080287

COMPLETED NA

Effect of Succinylcholine on Patients Using Statins

NCT00986583

COMPLETED NA

Comparison of 3 Techniques for Ultrasound-guided Femoral Nerve Catheter Insertion

NCT00927368

COMPLETED NA

Low Dose Thymoglobulin to Protect Kidney Function After Liver Transplant

NCT00970073

COMPLETED

The Efficacy Side Effects and the Tolerance of Polyethylene Glycol 3350 as a Bowel Prep in Children

NCT01164410

COMPLETED Phase 4

Prospective Evaluation of Vitagel for Reduction in Blood Loss and Pain Following Unilateral Total Knee Arthroplasty

NCT01027286

COMPLETED NA

Effect of Sildenafil on Diffusion Capacity in Patients With PH and Parenchymal Lung Disease

NCT01948518

COMPLETED NA

Timing of Direct Current Cardioversion (DCC) in Patients Undergoing Ablation of Persistent/Permanent Atrial Fibrillation

NCT02429648

TERMINATED

Evaluation of High-Density Lipoprotein in Obesity Study

NCT00912236

COMPLETED

Lacrimal Drainage Resistance Study

NCT01766232

COMPLETED NA

Quality of Life in Patients That Undergo J Pouch or Side to End Coloanal Anastomosis for Rectal Cancer

NCT01182116

COMPLETED Phase 4

Rejuvenation of the Lower Eyelid Using a Combination of Two Hyaluronic Acid Fillers - a Pilot Study

NCT00852241

COMPLETED NA

Interventional Study of Anxiety Symptoms in the Implantable Cardioverter Defibrillator (ICD) Patient

NCT00851071

COMPLETED NA

Effects of Meditation on Multiple Sclerosis and Peripheral Neuropathy

NCT00981643

TERMINATED NA

A Study of the Efficacy of Subcutaneous Phosphatidylcholine and Deoxycholate Injections for Localized Fat Removal

NCT00851747

TERMINATED Phase 2

Pregabalin for the Treatment of Vulvodynia

NCT00853229

COMPLETED

fMRI of the Brainstem in Migraine Sufferers and Controls. Does Iron Deposition Correlate With Progression of Disease?

NCT00868556

COMPLETED

Factors Predicting Positive Yields on Biliary Brush Cytology During Endoscopic Retrograde Cholangiopancreatography

NCT00894348

TERMINATED NA

The Effect of Dexamethasone on the Duration of Interscalene Nerve Blocks With Ropivacaine or Bupivacaine

NCT00801138

COMPLETED Phase 4

Evaluation of Intravenous Cardene(Nicardipine)and Labetalol Use in the Emergency Department

NCT00765648

COMPLETED Phase 3

Ultrasound Guided Supraclavicular Nerve Block

NCT00825786

COMPLETED

Chest Imaging, Breath, and Biomarkers in a Screening Trial

NCT01663155

COMPLETED

Costs of Postoperative Nausea and Vomiting in Ambulatory Surgery Patients

NCT00858949

COMPLETED Phase 2

Rilonacept for Treatment of Familial Mediterranean Fever (FMF)

NCT00582907

TERMINATED NA

Comparison Between the Fastrach and CTrach Laryngeal Mask Airway

NCT00814775

TERMINATED NA

Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain

NCT00720330

TERMINATED NA

Pulsed Dye Laser and Affirm Laser in the Treatment of Abdominoplasty Scars

NCT00735254

TERMINATED NA

Lidocaine and Ketamine in Abdominal Surgery

NCT00721110

COMPLETED NA

Mindfulness, Yoga, and Cardiovascular Disease

NCT00696852

COMPLETED NA

Hepatic Effects of Gastric Bypass Surgery

NCT00701376

COMPLETED NA

Perioperative Intravenous Lidocaine or Epidural Anesthesia on Outcomes in Complex Spine Surgery

NCT00840996

TERMINATED Phase 4

Hemodynamic and Inflammatory Effects of Abrupt Versus Tapered Corticosteroid Discontinuation in Septic Shock

NCT01150409

COMPLETED

Evaluation of ST2 and IL-33 in Patients Presenting to the Emergency Department With Trouble Breathing

NCT00707811

COMPLETED Phase 3

Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis

NCT00658736

COMPLETED NA

GlideScope Video Laryngoscope Versus Fiberoptic Intubation

NCT01091948

COMPLETED

Plasma Free Fatty Acids in Risk Assessment of Sepsis in the Emergency Department: A Prospective Pilot Study

NCT01530854

COMPLETED NA

Pentax Airway Scope (AWS) Intubation

NCT00667693

TERMINATED NA

Effect of Nortriptyline on Abdominal Pain/Discomfort and Quality of Life in Patients With Nonulcer Dyspepsia

NCT00547703

COMPLETED NA

A Controlled Trial of High Dietary Fiber Intake on Serum Lipids

NCT00593632

COMPLETED

Temperature Measurement in Post-Anesthesia Care Units

NCT00614588

COMPLETED NA

Comparison of Vital HEAT (vH2) Temperature Management System to Upper-body Forced-air Warming

NCT00815191

TERMINATED

PeriOperative Bridging - Perioperative Anticoagulation in the Setting of Recent Intracoronary Drug Eluting Stents

NCT00606151

COMPLETED

Sequential Cystatin C Levels and Renal Impairment in Acute Heart Failure

NCT00561483

COMPLETED Phase 2

Trial of Vascular Endothelial Growth Factor (VEGF), Bevacizumab, in Combination With Cytotoxic Chemotherapy for Endometrial Cancer

NCT00879359

COMPLETED

Intraocular Pressure During Spine Surgery

NCT00593359

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.