National Institute of Neurological Disorders and Stroke (NINDS)

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, National Institute of Neurological Disorders and Stroke (NINDS) sits in the top decile of US sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count).

567 total trials 48 currently recruiting 467 completed early-phase tilt top decile by trial count

National Institute of Neurological Disorders and Stroke (NINDS): 567 sponsored US clinical trials, 48 recruiting.

National Institute of Neurological Disorders and Stroke (NINDS) sponsors 567 registered US clinical trials on ClinicalTrials.gov, 48 of them currently recruiting, and 467 completed. 16 of these trials are in Phase 3-4 (later-stage) and 158 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Healthy, with 23 trials.

Top-decile sponsor footprint

National Institute of Neurological Disorders and Stroke (NINDS) ranks in the top decile of sponsors by registered trial count (#61 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

C 70/100

467 of 508 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (91.9%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

567 total, page 6 of 12

COMPLETED

Brain Excitability in Patients With Succinic Semialdehyde Dehydrogenase Deficiency

NCT00132366

COMPLETED Phase 1

Deep Brain Stimulation to Treat Cervical Dystonia

NCT00132340

COMPLETED

Mirroring a Movement

NCT00123448

COMPLETED

Neuropathology of Spasmodic Dysphonia

NCT00118586

COMPLETED

Interhemispheric Plasticity in Humans

NCT00120666

COMPLETED Phase 2

Double Blind Trial of DC Polarization in FTD

NCT00117858

COMPLETED

MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle

NCT00117221

COMPLETED

Motor Performance in Chronic Stroke Patients

NCT00110175

COMPLETED

Effects of Two Different Kinds of Exercise on Stroke Rehabilitation

NCT00108680

COMPLETED Phase 2

Talampanel to Treat Parkinson's Disease

NCT00108667

COMPLETED

Study to Collect Data on Fabry Disease Patients With Enhanceable Alpha-Galactosidase A Activity

NCT00106912

COMPLETED Phase 2

Transcranial Electrical Polarization to Treat Focal Hand Dystonia

NCT00106782

COMPLETED Phase 2

Deep Brain Stimulation for Cervical Dystonia

NCT00105430

COMPLETED

Genetic Characterization of Parkinson's Disease

NCT00105131

COMPLETED Phase 1

Nitrite Infusion in Healthy Volunteers

NCT00103025

COMPLETED

Effect of Surface Electrical Stimulation on Movement of the Larynx

NCT00104000

COMPLETED

Brain Function in Focal Dystonia

NCT00102999

COMPLETED Phase 2

Clinical Trial Characterizing the Bioavailability of 1-Octanol in Adults With Ethanol-responsive Essential Tremor

NCT00102596

COMPLETED

Brain Reorganization Following Constraint-Induced Therapy in Children With Cerebral Palsy

NCT00100503

COMPLETED

Biomarkers in Multiple Sclerosis

NCT00325988

COMPLETED

Magnetic Resonance Imaging to Detect Brain Damage in Patients With Multiple Sclerosis

NCT00099307

COMPLETED Phase 1

Safety Study of Interferon Beta 1a to for Acute Stroke

NCT00097318

COMPLETED

Brain Activities Associated With Different Facial Expressions Using Blood Oxygenation Level Dependent Functional MRI

NCT00096564

COMPLETED Phase 2

Non-Pharmacologic Therapy for Neurocardiogenic Syncope

NCT00096902

COMPLETED Phase 4

Replagal Enzyme Replacement Therapy for Adults With Fabry Disease

NCT00097890

COMPLETED

The Functional Anatomy of Personality Trait Knowledge: An fMRI Study

NCT00095407

COMPLETED Phase 2

Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance

NCT00093860

COMPLETED Phase 2

Effects of Lithium and Divalproex'on Brain-Derived Neurotrophic Factor in Huntington's Disease

NCT00095355

COMPLETED

Neural Correlates of Observation of Tactile Stimulation in Healthy Subjects

NCT00091533

COMPLETED Phase 2

Rituximab to Treat Stiff Person Syndrome

NCT00091897

COMPLETED Phase 2

Lisuride Patch to Treat Parkinson's Disease

NCT00089622

COMPLETED

Treatment Study of Frontotemporal Dementia

NCT00088751

COMPLETED Phase 3

Comparison of TransMID vs Standard Treatment of Cancerous Brain Tumors

NCT00088400

COMPLETED Phase 2

Effect of Lithium and Divalproex in Alzheimer's Disease

NCT00088387

COMPLETED

Effect of Direct Current Polarization on Brain Function

NCT00088569

COMPLETED

Biological Markers in Parkinson's Disease

NCT00088335

COMPLETED Phase 2

ACP-103 to Treat Parkinson's Disease

NCT00086294

COMPLETED

Brain Electrical Stimulation to Enhance Recovery After Stroke

NCT00085657

COMPLETED

Herpes Virus-6 and Epilepsy

NCT00085683

COMPLETED

Observational Learning in Stroke Patients

NCT00083642

COMPLETED

Role of the Brain in Making Economic Decisions

NCT00083317

COMPLETED

Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives

NCT00082615

COMPLETED

Pelvic Pain in Women With Endometriosis

NCT00073801

COMPLETED

Language and Emotional Function in Patients With Temporal Lobe Epilepsy

NCT00081432

COMPLETED

Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder

NCT00081419

COMPLETED

Timing of Voluntary Movement in Patients With Schizophrenia

NCT00080548

COMPLETED

Brain Physiology in Polio Survivors

NCT00080600

COMPLETED

Rhythm Perception and Generation

NCT00080067

COMPLETED Phase 2

Octanol to Treat Essential Tremor

NCT00080366

COMPLETED Phase 2

Alemtuzumab to Treat Sporadic Inclusion Body Myositis

NCT00079768

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Phase Distribution

PhaseTrial count
Phase 1 80
Phase 2 78
Phase 3 11
Phase 4 5

What is open in the National Institute of Neurological Disorders and Stroke (NINDS) pipeline

48 recruiting of 567 indexed (8% open); 467 completed (82%).

Phase mix: 16 late (III/IV) vs 158 early (I/II) (early-phase heavy).

Top condition: Healthy (23 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

National Institute of Neurological Disorders and Stroke (NINDS): open-pipeline peers nationwide

Peers matched on 567 registered trials and 8% open enrollment, not the therapeutic-area sidebar.

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 0200400600 5%10%15%20%25% Total trials Recruiting share National Institute of Neurological Disorders and Stroke (NINDS)Children's Hospital Medical Center, CincinnatiUniversity of Maryland, BaltimoreAmgenMerck Sharp & DohmeNational Jewish HealthACADIA PharmaceuticalsTexas Tech University Health Sciences Center, El PasoBoehringer Ingelheim
National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

National Institute of Neurological Disorders and Stroke (NINDS) sits at or above the median trial volume and below the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 567 trials (± recruiting share)

Sponsors near 8% open enrollment (± trial volume)

What to do with this National Institute of Neurological Disorders and Stroke (NINDS) page

567 registered trials is a research-attention snapshot, not an endorsement of National Institute of Neurological Disorders and Stroke (NINDS) or any single study.

  • 48 of National Institute of Neurological Disorders and Stroke (NINDS)'s trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Healthy is the condition National Institute of Neurological Disorders and Stroke (NINDS) studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Healthy trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. National Institute of Neurological Disorders and Stroke (NINDS) pipeline card: 567 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.