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NCT00093860 · ClinicalTrials.gov registry record · Phase 2
Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance
A Phase 2 study of Syncope, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- Phase 2
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT00093860: Completed Phase 2 study of Syncope, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
NCT00093860 is a Phase 2 study of Syncope that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 50 participants, below the 846-participant average among 11 other Syncope trials with a reported enrollment target (94% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00093860, a Phase 2 study of Syncope, has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI). SAI is a particular pattern of nervous system and chemical responses in which the blood vessels in skeletal muscles do not remain constricted appropriately during standing for a long time. This can lower blood pressure and cause fainting. Propranolol (Inderal® (Registered Trademark)) is a Food and Drug Administration-approved drug that belongs to a class of drugs called beta-blockers. These drugs slow the heart rate and maintain blood pressure in certain situations. Children between 10 and 17 years of age with frequent fainting or near-fainting due to SAI may be eligible for this study. Children must experience severe dizzy episodes at least once every 2 months or fainting episodes at least once every 4 months. The condition must be severe enough to affect the child's quality of life or to have forced the child to alter his or her life routines to accommodate to the illness. Screening includes a tilt table test, described below, to determine if the child has a particular chemical pattern in the blood. Children enrolled in the study take propranolol pills in increasing doses during the first week of the study to determine the proper dose for the individual. Then, the drug is stopped until the experimental phase of the study begins. In this phase, children are randomly assigned to take either propranolol or placebo (a look-alike pill with no active ingredient) for a maximum of 3 days. On the fourth day, the child undergoes a tilt table test to determine whether the treatment affects his or her ability to tolerate tilt. For this test, the child lies on a padded table with a motorized tilt mechanism that can move the child from a flat position to an upright position in about 10 seconds. The child remains upright for up to 40 minutes while the following measurements are taken: * Blood sampling: Blood is drawn through a catheter (th
Conditions Studied
Interventions
- DRUG Propranolol
Study Locations (1)
Maryland
- National Institute of Neurological Disorders and Stroke (NINDS) - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2004-10 |
| Est. Completion | 2005-03 |
| Phase | Phase 2 |
What the finished NCT00093860 record still lists
NCT00093860 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 846-participant average among 11 other Syncope trials with a reported enrollment target (94% lower).
The record links to 1 condition, with Syncope appearing as the primary indexed condition, and to 1 intervention - of which Propranolol is the first listed.
NCT00093860 reports a single indexed study location in Maryland.
Frequently Asked Questions
What is clinical trial NCT00093860 about?
NCT00093860 is a clinical study titled "Propranolol to Treat Fainting in Children With Sympathoadrenal Imbalance". This study will examine the effectiveness of the drug propranolol in preventing fainting in patients with sympathoadrenal imbalance (SAI). SAI is a particular pattern of nervous system and chemical responses in which the blood vessels in skeletal muscles do not remain constricted appropriately durin...
What is the current status of trial NCT00093860?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 50 participants. The study started on 2004-10. Estimated completion is 2005-03.
What conditions does trial NCT00093860 study?
This clinical trial studies the following conditions: Syncope.
What interventions are being tested in trial NCT00093860?
The interventions under investigation include: Propranolol (DRUG).
Who is sponsoring clinical trial NCT00093860?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00093860 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Syncope
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00093860's enrollment target sits among peer trials
50 10th of 11 higher than 2 of 11 other Syncope trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Syncope trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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