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NCT00096564 · ClinicalTrials.gov registry record
Brain Activities Associated With Different Facial Expressions Using Blood Oxygenation Level Dependent Functional MRI
A clinical trial, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- Completed
- Registry status
- 25
- Enrollment target
NCT00096564 is a clinical trial that has completed, run by National Institute of Neurological Disorders and Stroke (NINDS). The registered enrollment target is 25 participants.
The verdict
NCT00096564 has completed, sponsored by National Institute of Neurological Disorders and Stroke (NINDS).
- COMPLETED
- Registry status
- 25 participants
- Enrollment target
Study Summary
Objectives: The purpose of this study is to identify areas of brain activation during the urge to yawn. Little is known about how yawning is suppressed, or why yawning often occurs in response to seeing another person yawn (contagious yawning). Contagious yawning is similar to other contagious motor programs, such as the greater urge Tourette subjects feel to tic when seeing repetitive movements or other subjects' tics, the urge to scratch when discussing itching and scratching, or the urge to urinate when hearing running water. Hypothetically, the urge or the suppression of this urge is modulated by a common cortical circuit implicated in Tourette syndrome. We plan to use functional magnetic resonance imaging (fMRI) to identify the pattern of blood oxygenation level-dependent (BOLD) activation in the brain when normal volunteers feel the urge to yawn. Study Population: We intend to study 25 normal, right-handed, healthy volunteers. Study Design: Using an event-related design, we will scan subjects, using the same 3T fMRI scanner, while showing a video of a person yawning, gaping, coughing, or doing nothing. Each of these four action stimuli will last for four seconds, with varying interstimulus intervals. Each video set will contain all actions displayed ten times pseudorandomly. Two data sets will be collected from each subject and will be separated by a brief rest period. Subjects will be instructed before the scan to watch a videotaped person perform various behaviors, without detailing the specific actions. So as not to influence their natural response to the yawning stimulus, we will instruct them only to keep their head still. The variable of interest will be the activation during urge-generation, contrasted with other control stimuli. A survey will be administered for informational purposes following the scan to assess the subjects' general impression of their susceptibility to yawning, whether they yawned in the scanner, whether they suppressed the urge t
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2004-11-09 |
| Est. Completion | 2008-08-20 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00096564
The ClinicalTrials.gov registry entry for NCT00096564 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 25 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00096564 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00096564 about?
NCT00096564 is a clinical study titled "Brain Activities Associated With Different Facial Expressions Using Blood Oxygenation Level Dependent Functional MRI". Objectives: The purpose of this study is to identify areas of brain activation during the urge to yawn. Little is known about how yawning is suppressed, or why yawning often occurs in response to seeing another person yawn (contagious yawning). Contagious yawning is similar to other contagious motor...
What is the current status of trial NCT00096564?
This trial is currently completed. The enrollment target is 25 participants. The study started on 2004-11-09. Estimated completion is 2008-08-20.
Who is sponsoring clinical trial NCT00096564?
This trial is sponsored by National Institute of Neurological Disorders and Stroke (NINDS), which has 567 total clinical trials registered on ClinicalTrials.gov.
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