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NCT00229619 · ClinicalTrials.gov registry record · Phase 2
Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia
A Phase 2 study of Anemia, Aplastic and Anemia, Diamond-Blackfan, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- Completed
- Registry status
- Phase 2
- Development phase
- 11
- Enrollment target
- 1
- Study location
NCT00229619 is a Phase 2 study of Anemia, Aplastic and Anemia, Diamond-Blackfan that has completed, run by National Heart, Lung, and Blood Institute (NHLBI). The registered enrollment target is 11 participants, below the 539-participant average among 5 other Anemia, Aplastic trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state.
The verdict
NCT00229619, a Phase 2 study of Anemia, Aplastic and Anemia, Diamond-Blackfan, has completed, sponsored by National Heart, Lung, and Blood Institute (NHLBI).
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 11 participants
- Enrollment target
- 1
- Study location
Study Summary
This study will test whether the immune-suppressing drug rituximab can increase blood counts and reduce the need for transfusions in patients with moderate aplastic anemia, pure red cell aplasia, or Diamond Blackfan anemia. These are rare and serious blood disorders in which the immune system turns against bone marrow cells, causing the bone marrow to stop producing red blood cells in patients with pure red cell aplasia and Diamond Blackfan anemia, and red blood cells, white blood cells and platelets in patients with aplastic anemia. Rituximab is a laboratory-made monoclonal antibody that recognizes and destroys white blood cells called lymphocytes that are responsible for destroying bone marrow cells in these diseases. The drug is currently approved by the Food and Drug Administration for treating patients with B-cell non-Hodgkin lymphoma, a disease of white blood cells.
Conditions Studied
Interventions
- DRUG Rituximab
Study Locations (1)
Maryland
- National Institutes of Health Clinical Center, 9000 Rockville Pike - Bethesda
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2005-09 |
| Est. Completion | 2010-06 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00229619
The ClinicalTrials.gov registry entry for NCT00229619 describes a study currently listed as completed, categorized as Phase 2. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 539-participant average among 5 other Anemia, Aplastic trials with a reported enrollment target (98% lower). The listed sponsor is National Heart, Lung, and Blood Institute (NHLBI), which has 501 total studies on file at ClinicalTrials.gov.
The record links to 3 conditions, with Anemia, Aplastic appearing as the primary indexed condition, and to 1 intervention - of which Rituximab is the first listed.
NCT00229619 reports 1 study location spanning 1 distinct geographic area - top geographies include Maryland.
Frequently Asked Questions
What is clinical trial NCT00229619 about?
NCT00229619 is a clinical study titled "Rituximab to Treat Moderate Aplastic Anemia, Pure Red Cell Aplasia, or Diamond Blackfan Anemia". This study will test whether the immune-suppressing drug rituximab can increase blood counts and reduce the need for transfusions in patients with moderate aplastic anemia, pure red cell aplasia, or Diamond Blackfan anemia. These are rare and serious blood disorders in which the immune system turns ...
What is the current status of trial NCT00229619?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 11 participants. The study started on 2005-09. Estimated completion is 2010-06.
What conditions does trial NCT00229619 study?
This clinical trial studies the following conditions: Anemia, Aplastic, Anemia, Diamond-Blackfan, Red-Cell Aplasia, Pure.
What interventions are being tested in trial NCT00229619?
The interventions under investigation include: Rituximab (DRUG).
Who is sponsoring clinical trial NCT00229619?
This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 501 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00229619 being conducted?
This trial has 1 study location across Maryland. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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