National Heart, Lung, and Blood Institute (NHLBI)

501 total trials 62 currently recruiting 381 completed

National Heart, Lung, and Blood Institute (NHLBI) sponsors 501 registered US clinical trials on ClinicalTrials.gov, 62 of them currently recruiting, and 381 completed. 33 of these trials are in Phase 3-4 (later-stage) and 205 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atherosclerosis, with 12 trials.

Trial Pipeline

501 total, page 5 of 11

COMPLETED Phase 1

A Pilot Study of Fludarabine Plus Cyclophosphamide in Refractory Severe Aplastic Anemia

NCT01187017

COMPLETED

Effects of Rosuvastatin on the Immune System in Healthy Volunteers With Normal Cholesterol

NCT01200836

COMPLETED Phase 2

Ofatumumab-based Induction Chemoimmunotherapy in Previously Untreated Patients With CLL/SLL

NCT01145209

COMPLETED

A Study of the Kinetics of Lymphoid Cells in Patients With Monoclonal B-cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL), Mantle Cell Lymphoma (MCL) and Healthy Volunteers

NCT01117142

COMPLETED Phase 1

Gardasil Vaccination in Post Stem Cell Transplant Patients

NCT01092195

COMPLETED Phase 3

Stem Cell Transplant With Lenalidomide Maintenance in Patients With Multiple Myeloma (BMT CTN 0702)

NCT01109004

COMPLETED Phase 2

Evaluation of Oral Alpha-Cyclodextrin for Decreasing Serum Cholesterol

NCT01131299

COMPLETED

New Techniques to Evaluate Mitral Regurgitation

NCT01063322

TERMINATED Phase 3

Statins for Acutely Injured Lungs From Sepsis

NCT00979121

COMPLETED

Cardiac MRI for Patients Enrolled in INFUSE-AMI

NCT01059214

COMPLETED

Novel Influenza A (H1N1) Surveillance Registry

NCT01046331

COMPLETED

Characterization of the Innate Immune Response in Healthy NIH Employees at Baseline and After Immunization With the H1N1 Vaccine

NCT00995527

COMPLETED Phase 2

A Randomized, Placebo-Controlled, Double-Blind Pilot Study of Pioglitazone Hydrochloride in Severe, Refractory Asthma

NCT00994175

COMPLETED

Cellular and Molecular Characterization of the Immune Response in Healthy NIH Employees atBaseline, and After Immunization With the H1N1 or Seasonal Influenza Vaccines

NCT01191853

COMPLETED

Collection of Blood, Bone Marrow, and Buccal Mucosa Samples From Healthy Volunteers for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Laboratory Research Studies

NCT00995891

COMPLETED Phase 3

Clarification of Optimal Anticoagulation Through Genetics

NCT00839657

COMPLETED Phase 2

Horse ATG/CsA in Aplastic Anemia Patients Unresponsive to or With a Suboptimal Response to Rabbit ATG/CsA Treatment

NCT00944749

COMPLETED

Screening Protocol for Subjects Being Evaluated for Center for Human Immunology, Autoimmunity, and Inflammatory Diseases (CHI) Protocols

NCT00968084

COMPLETED

X-ray Fluoroscopy Fused With Computed Tomography (XFC) Technical Development

NCT00965679

COMPLETED

Comparison of Cardiac Computed Tomography and Vasodilator Stress Magnetic Resonance Imaging Perfusion in Patients With Prior Equivocal Stress Test for Detection of Coronary Artery Disease

NCT00929227

COMPLETED Phase 2

A Pilot Study of the Thrombopoietin-Receptor Agonist Eltrombopag in Refractory Aplastic Anemia Patients

NCT00922883

COMPLETED Phase 1

A Pilot Study of the Safety and Activity of Escalating Doses of ON 01910.Na in Patients With Relapsed Mantle Cell Lymphoma, Multiple Myeloma, Chronic Lymphocytic Leukemia, and Related Lymphoid Malignancies

NCT00861510

COMPLETED NA

Mismatched Donor Lymphocyte Infusions for Relapsed Disease Following Allogeneic Stem Cell Transplantation

NCT00859586

COMPLETED

Pilot Study of Mitochondrial Biology in Human Platelets

NCT00833846

COMPLETED Phase 3

Long-term Oxygen Treatment Trial

NCT00692198

COMPLETED

Collection of Blood and Bone Marrow Samples From Select Patients With CML to Measure Minimal Residual Disease

NCT00819143

COMPLETED Phase 3

Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery

NCT00836329

COMPLETED

Neuropsychological Effects of Immunosuppressive Treatment in Subjects With Aplastic Anemia

NCT00767650

COMPLETED

Identification of Risk Factors for Arrhythmia in Children and Adolescents With Hypertrophic Cardiomyopathy

NCT00753233

COMPLETED

Long-Term Effects of Hydroxyurea in Children With Sickle Cell Anemia (The BABY HUG Follow-up Study)

NCT00890396

COMPLETED NA

Multisystemic Therapy to Reduce Health Disparities in Adolescents With Asthma

NCT00916240

COMPLETED Phase 1

Natural Killer Cells and Bortezomib to Treat Cancer

NCT00720785

TERMINATED

Transfusion-Associated Microchimerism in Previously Injured Individuals Who Received a Blood Transfusion

NCT00441779

TERMINATED

Technical Development of Interventional Cardiovascular Magnetic Resonance Imaging in Normal Volunteers

NCT00720460

COMPLETED

Screening for Subjects to Participate in Studies of Blood Disorders

NCT00695123

COMPLETED Phase 2

Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelodysplastic Syndrome

NCT00604201

COMPLETED Phase 2

Effects of Worksite Wellness Interventions on Vascular Function, Insulin Sensitivity and High-Density Lipoprotein in Overweight or Obese Women

NCT00666172

COMPLETED

Evaluation of Toxicity From Stem Cell Transplant

NCT00631787

TERMINATED

Biomarkers in Exhaled Breath From Asthmatic Patients

NCT00635271

COMPLETED

Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia

NCT00011648

TERMINATED

Cardiovascular Disease Screening

NCT00483951

COMPLETED

Pilot Study to Assess the Proteome in Human Atrial Tissue

NCT00591903

COMPLETED Phase 3

Early Versus Delayed Enteral Feeding to Treat People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN Study)

NCT00883948

TERMINATED Phase 3

Early Versus Delayed Enteral Feeding and Omega-3 Fatty Acid/Antioxidant Supplementation for Treating People With Acute Lung Injury or Acute Respiratory Distress Syndrome (The EDEN-Omega Study)

NCT00609180

COMPLETED

Relation of White Blood Cell Function to Diabetes

NCT00570154

COMPLETED

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions

NCT01322165

COMPLETED

Effect of Fasting on the Size of Abdominal Lymphatic Tumors in Women

NCT00552955

COMPLETED Phase 1

Safety of ON 01910.Na in Patients With Myelodysplasia

NCT00533416

COMPLETED NA

Longitudinal Studies of HIV-Associated Lung Infections and Complications (Lung HIV)

NCT00933595

COMPLETED

Association Between Abdominal Body Composition, Inflammation, and Risk for Cardiovascular Disease (The MESA ABD Study)

NCT00612365

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Phase Distribution

PhaseTrial count
Phase 1 87
Phase 2 118
Phase 3 29
Phase 4 4

What the Pipeline for National Heart, Lung, and Blood Institute (NHLBI) Shows

According to the ClinicalTrials.gov registry, National Heart, Lung, and Blood Institute (NHLBI) is linked to 501 US clinical trials across every stage of research activity. Of those, 62 studies are currently recruiting, about 12% of the sponsor's indexed portfolio, and 381 are already marked complete, representing roughly 76% of the total.

The phase mix for National Heart, Lung, and Blood Institute (NHLBI) reports 33 late-stage studies (Phase 3 and Phase 4 combined) and 205 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for National Heart, Lung, and Blood Institute (NHLBI) is Atherosclerosis with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.