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Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)
NCT02208037 · View on ClinicalTrials.gov ↗
Study Summary
Acute Graft-versus-Host-Disease (GVHD) is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). This study aims to determine if any of three new GVHD prophylaxis approaches improves the rate of GVHD and relapse free survival at one year after transplant compared to the current standard prophylaxis regimen.
Conditions Studied
Interventions
- DRUG Maraviroc
- DRUG Tacrolimus (ARM with Methotrexate)
- DRUG Tacrolimus (ARM with MMF and Cyclophosphamide)
- DRUG Methotrexate (ARM with Maraviroc)
- DRUG Methotrexate (ARM with Bortezomib)
Study Locations (20)
California
- City of Hope National Medical Center — Duarte
- Stanford Hospital and Clinics — Stanford
Florida
- University of Florida College of Medicine (Shands) — Gainesville
- H. Lee Moffitt Cancer Center — Tampa
Georgia
- Emory University — Atlanta
- BMT Program at Northside Hospital — Atlanta
Massachusetts
- Dana Farber Cancer Institute/Massachusetts General Hospital — Boston
- Dana Farber Cancer Institute/Brigham & Women's — Boston
Minnesota
- University of Minnesota — Minneapolis
- Mayo Clinic - Rochester — Rochester
New York
- Roswell Park Cancer Institute — Buffalo
- Memorial Sloan-Kettering Cancer Center — Manhattan
Illinois
- Loyola University Medical Center — Maywood
Iowa
- University of Iowa Hospitals and Clinics — Iowa City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 279 participants |
| Start Date | 2014-08 |
| Est. Completion | 2017-10 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT02208037
The ClinicalTrials.gov registry entry for NCT02208037 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 279 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Heart, Lung, and Blood Institute (NHLBI), which has 381 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 9 conditions, with Chronic Lymphocytic Leukemia appearing as the primary indexed condition, and to 5 interventions — of which Maraviroc is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT02208037 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Florida, Georgia. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT02208037 about?
NCT02208037 is a clinical study titled "Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)". Acute Graft-versus-Host-Disease (GVHD) is an important cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). This study aims to determine if any of three new GVHD prophylaxis approaches improves the rate of GVHD and relapse free survival at one year after ...
What is the current status of trial NCT02208037?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 279 participants. The study started on 2014-08. Estimated completion is 2017-10.
What conditions does trial NCT02208037 study?
This clinical trial studies the following conditions: Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, Acute Leukemia, Lymphoma, B-Cell, Chronic Myelogenous Leukemia. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT02208037?
The interventions under investigation include: Maraviroc (DRUG), Tacrolimus (ARM with Methotrexate) (DRUG), Tacrolimus (ARM with MMF and Cyclophosphamide) (DRUG), Methotrexate (ARM with Maraviroc) (DRUG), Methotrexate (ARM with Bortezomib) (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT02208037?
This trial is sponsored by National Heart, Lung, and Blood Institute (NHLBI), which has 381 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT02208037 being conducted?
This trial has 20 study locations across California, Florida, Georgia, Illinois, Iowa. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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