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NCT00055029 · ClinicalTrials.gov registry record
Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis
A clinical trial of Retinoschisis, sponsored by National Eye Institute (NEI).
- Active
- Registry status
- 351
- Enrollment target
- 2
- Study locations
NCT00055029 is a study of Retinoschisis that is active but no longer recruiting, run by National Eye Institute (NEI). The registered enrollment target is 351 participants. The trial reports 2 study locations across 2 states.
The verdict
NCT00055029, a study of Retinoschisis, is active but no longer recruiting, sponsored by National Eye Institute (NEI).
- ACTIVE NOT RECRUITING
- Registry status
- 351 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study will explore the causes and eye problems of X-linked juvenile retinoschisis (XLRS), an inherited disease that causes vision loss primarily in young males. The vision loss, which worsens over time, is a result of schisis, or splitting, of the layers of the retina (tissue that lines the back of the eye). A better understanding of why and how XLRS develops might lead to improved treatments. Patients 9 months of age and older with XLRS and females who are suspected carriers of the gene responsible for the disease (such as the mother of the patient) may be eligible for this study. Other family members of patients also may be enrolled. Patients will undergo the following tests and procedures: * Personal and family medical history to review past and current medical conditions and treatments, particularly regarding eye disease, and to construct a family tree. * Eye examination to assess visual acuity (eye chart test) and examine pupils, lens, retina, and eye movements. The pupils will be dilated with drops for this examination. * Photography of the retina to help evaluate the status of the retina. * Specialized eye tests to evaluate color vision, field of vision, and ability to see in the dark. * Electroretinogram (ERG) to examine what happens to the eyes after a flash of bright light. For this test, the patient sits in a dark room for 30 minutes with his or her eyes patched. Then, a small silver disk electrode is taped to the forehead, the eye patches are removed, the surface of the eye is numbed with eye drops and contact lenses are placed on the eyes. The patient looks inside a large empty bowl and then a light flashes, first in the dark and then with a light turned on inside the bowl. The contact lenses sense small electrical signals generated by the retina when the light flashes. * Blood test to examine DNA for genetic study of XLRS. Family members will provide a blood sample for genetic study.
Conditions Studied
Study Locations (2)
Maryland
- National Institutes of Health Clinical Center - Bethesda
Michigan
- William Beaumont Hospital - Rochester
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 351 participants |
| Start Date | 2003-05-19 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00055029
The ClinicalTrials.gov registry entry for NCT00055029 describes a study currently listed as active not recruiting, categorized as an unspecified phase. The registered enrollment target is 351 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Eye Institute (NEI), which has 221 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Retinoschisis appearing as the primary indexed condition, and to 0 interventions.
NCT00055029 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Maryland, Michigan.
Frequently Asked Questions
What is clinical trial NCT00055029 about?
NCT00055029 is a clinical study titled "Clinical and Genetic Studies of X-Linked Juvenile Retinoschisis". This study will explore the causes and eye problems of X-linked juvenile retinoschisis (XLRS), an inherited disease that causes vision loss primarily in young males. The vision loss, which worsens over time, is a result of schisis, or splitting, of the layers of the retina (tissue that lines the bac...
What is the current status of trial NCT00055029?
This trial is currently active not recruiting. The enrollment target is 351 participants. The study started on 2003-05-19.
What conditions does trial NCT00055029 study?
This clinical trial studies the following conditions: Retinoschisis.
Who is sponsoring clinical trial NCT00055029?
This trial is sponsored by National Eye Institute (NEI), which has 221 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00055029 being conducted?
This trial has 2 study locations across Maryland, Michigan. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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