Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 7 recruiting now official registry

Castration-resistant Prostate Cancer clinical trials

7 of 16 indexed Castration-resistant Prostate Cancer trials are currently recruiting.

16 US clinical trials · 7 currently recruiting

Castration-resistant Prostate Cancer is the subject of 16 registered US clinical trials on ClinicalTrials.gov, 7 of them currently open to new participants. 2 are in Phase 3-4 (later-stage) and 12 in Phase 1-2 (earlier-stage). The most active sponsor is Exelixis, running 2 of these trials.

The research picture

Castration-resistant Prostate Cancer has 16 registered US clinical trials, 7 of them open to new participants right now, about 44% of the total.

7
recruiting participants now
44%
of trials open to enrollment
2
in Phase 3–4 (later-stage)
2
top sponsor: Exelixis
Phase 16Phase 26Phase 31Phase 41

Active & Recent Trials

16 total, page 1 of 1

RECRUITING Phase 2 532 participants

Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE Trial

Mayo Clinic

NCT06378866

RECRUITING 120 participants

ARCTIC: Liquid Biomarkers in the Prospective Androgen Receptor Signaling Inhibitors (ARSI) Resistance Clinical Trials

Duke University

NCT06141993

RECRUITING Phase 2 100 participants

Study of Apalutamide With Carotuximab in Metastatic, Castration-Resistant Prostate Cancer

Edwin Posadas, MD

NCT05534646

RECRUITING Phase 4 80 participants

Evaluation of the Change in PSMA Expression in Prostate Cancer in Response to Hormonal Therapy

OHSU Knight Cancer Institute

NCT05919329

RECRUITING Phase 1 60 participants

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Deciphera Pharmaceuticals

NCT06966024

RECRUITING Phase 2 47 participants

Study of Cabozantinib and Nivolumab in Metastatic Castration Resistant Prostate Cancer

Rana McKay, MD

NCT05502315

RECRUITING Phase 1 30 participants

GZ17-6.02 in Advanced CRPC After Progression on Anti-Androgen Therapy

Virginia Commonwealth University

NCT06636123

ACTIVE NOT RECRUITING Phase 1 914 participants

Study of Cabozantinib Alone or in Combination With Atezolizumab to Subjects With Locally Advanced or Metastatic Solid Tumors

Exelixis

NCT03170960

ACTIVE NOT RECRUITING Phase 2 60 participants

pTVG-HP DNA Vaccine With or Without pTVG-AR DNA Vaccine and Pembrolizumab in Patients With Castration-Resistant, Metastatic Prostate Cancer

University of Wisconsin, Madison

NCT04090528

COMPLETED Phase 3 1,028 participants

Study of Cabozantinib (XL184) Versus Prednisone in Men With Metastatic Castration-resistant Prostate Cancer Previously Treated With Docetaxel and Abiraterone or MDV3100

Exelixis

NCT01605227

COMPLETED Phase 2 120 participants

I-131-1095 Radioligand Plus Enzalutamide vs Enzalutamide for mCRPC That Progressed During Abiraterone (ARROW).

Progenics Pharmaceuticals

NCT03939689

COMPLETED Phase 1 54 participants

INCB106385 Alone or in Combination With Immunotherapy in Advanced Solid Tumors

Incyte Corporation

NCT04580485

COMPLETED Phase 2 38 participants

Trial of NRX 194204 in Castration- and Taxane-Resistant Prostate Cancer

Io Therapeutics

NCT01540071

COMPLETED Early Phase 1 30 participants

Testosterone Therapy in Castration Resistant Prostate Cancer

University of Colorado, Denver

NCT03734653

COMPLETED Phase 1 24 participants

Crizotinib in Combination With Enzalutamide in Metastatic Castration-resistant Prostate Cancer

Dana-Farber Cancer Institute

NCT02207504

COMPLETED NA 22 participants

Home-based Exercise Intervention for Patients With Metastatic Prostate Cancer

UNC Lineberger Comprehensive Cancer Center

NCT03672396

Phase Distribution

PhaseTrial count
Phase 1 6
Phase 2 6
Phase 3 1
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Castration-resistant Prostate Cancer Trial Landscape

16 indexed Castration-resistant Prostate Cancer studies · 7 recruiting (44%).

Phase mix: 2 late (III/IV) vs 12 early (I/II).

Top sponsor: Exelixis (2 trials), 9 others listed. 16 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Castration-resistant Prostate Cancer?

PlainTrial tracks 16 US clinical trials for Castration-resistant Prostate Cancer, of which 7 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Castration-resistant Prostate Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.