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ClinicalTrials.gov 19 recruiting now official registry

Hormone Receptor-Positive Breast Cancer clinical trials

19 of 24 indexed Hormone Receptor-Positive Breast Cancer trials are currently recruiting.

24 US clinical trials · 19 currently recruiting

Hormone Receptor-Positive Breast Cancer is the subject of 24 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 21 in Phase 1-2 (earlier-stage). The most active sponsor is Exelixis, running 2 of these trials.

The research picture

Hormone Receptor-Positive Breast Cancer has 24 registered US clinical trials, 19 of them open to new participants right now, about 79% of the total.

19
recruiting participants now
79%
of trials open to enrollment
1
in Phase 3–4 (later-stage)
2
top sponsor: Exelixis
Phase 113Phase 28Phase 41

Active & Recent Trials

24 total, page 1 of 1

RECRUITING Phase 1 396 participants

Study of XB010 in Subjects With Solid Tumors

Exelixis

NCT06545331

RECRUITING Phase 2 375 participants

A Single Arm Phase II Study of ADjuvant Endocrine Therapy, Pertuzumab, and Trastuzumab for Patients With Anatomic Stage I Hormone Receptor-positive, HER2-positive Breast Cancer

Dana-Farber Cancer Institute

NCT04569747

RECRUITING Phase 1 300 participants

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

BeiGene

NCT06120283

RECRUITING Phase 2 297 participants

PhII Randomized CAPecitabine + ELAcestrant vs. Capecitabine Alone in ER+ Breast Cancer (CAPELA)

Kristina A. Fanucci

NCT07222215

RECRUITING Phase 1 258 participants

A Study to Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

BeiGene

NCT06257264

RECRUITING Phase 2 200 participants

Ribociclib And Endocrine Treatment of Physician's Choice for Locoregional Recurrent, Resected Hormone Receptor Positive HER2 Negative Breast Cancer

Oana Danciu

NCT05467891

RECRUITING Phase 2 185 participants

Correlation of Clinical Response to Pathologic Response in Patients With Early Breast Cancer

Baylor Breast Care Center

NCT05020860

RECRUITING 170 participants

Study of Screening Brain MRIs in Stage IV Breast Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT05115474

RECRUITING Phase 1 120 participants

BGB-21447 (Bcl-2 Inhibitor) Combinations for Adults With Hormone-Receptor Positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Metastatic Breast Cancer

BeOne Medicines

NCT06756932

RECRUITING 100 participants

DiviTum®TKa: A Biomarker Assay for Efficacy in HR+ Metastatic Breast Cancer Patients

Mayo Clinic

NCT06388122

RECRUITING Phase 1 95 participants

Phase 1/2 Study to Evaluate EP0062 as Monotherapy and in Combination in Patients With Advanced or Metastatic AR+/HER-2-/ER+ Breast Cancer

Ellipses Pharma

NCT05573126

RECRUITING Phase 2 75 participants

Sequencing Antibody Drug Conjugates in ER+/HER2 LOW/ULTRA LOW MBC

Reshma L. Mahtani, D.O.

NCT06263543

RECRUITING Phase 1 63 participants

VS-6766+Abema+Fulv in Met HR+/HER- BC

Adrienne G. Waks

NCT05608252

RECRUITING Phase 4 60 participants

A Study of Revaree Plus in People With Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT07042581

RECRUITING Phase 2 60 participants

ETHAN - ET for Male BC

Jose Pablo Leone

NCT05501704

RECRUITING Phase 2 40 participants

Tirzepatide for Weight Loss Intervention in Early-Stage Hormone Receptor Positive/HER2 Negative Breast Cancer

Rutgers, The State University of New Jersey

NCT06518837

RECRUITING Phase 1 28 participants

A Study of Abemaciclib and Radiation Therapy in People With Metastatic Breast Cancer

Memorial Sloan Kettering Cancer Center

NCT06678269

RECRUITING Phase 1 20 participants

A Study to Assess CLBR001+ABBV-461 in Subjects With Locally Advanced or Metastatic Breast Cancer

Calibr, a division of Scripps Research

NCT06878248

RECRUITING Phase 2 20 participants

Anastrazole, Fulvestrant & Abemaciclib for HR+HER2- Metastatic Breast Cancer

University of California, Irvine

NCT05524584

ACTIVE NOT RECRUITING Phase 1 890 participants

First-in-human Study of DS-1062a for Advanced Solid Tumors (TROPION-PanTumor01)

Daiichi Sankyo Co.

NCT03401385

ACTIVE NOT RECRUITING Phase 1 70 participants

TH1902 in Patients With Advanced Solid Tumors

Theratechnologies

NCT04706962

ACTIVE NOT RECRUITING Phase 1 13 participants

Capecitabine In Combination With Cemiplimab In Patient With Metastatic Breast Cancer

H. Lee Moffitt Cancer Center and Research Institute

NCT05064085

COMPLETED Phase 1 269 participants

Study of XB002 in Subjects With Solid Tumors (JEWEL-101)

Exelixis

NCT04925284

COMPLETED Phase 1 226 participants

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Celgene

NCT01177397

Phase Distribution

PhaseTrial count
Phase 1 13
Phase 2 8
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Hormone Receptor-Positive Breast Cancer Trial Landscape

24 indexed Hormone Receptor-Positive Breast Cancer studies · 19 recruiting (79%).

Phase mix: 1 late (III/IV) vs 21 early (I/II).

Top sponsor: Exelixis (2 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Hormone Receptor-Positive Breast Cancer?

PlainTrial tracks 24 US clinical trials for Hormone Receptor-Positive Breast Cancer, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Hormone Receptor-Positive Breast Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.