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NCT06962332 · ClinicalTrials.gov registry record · Phase 1
Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)
A Phase 1 study of Hepatic Impairment and Moderate Hepatic Impairment, sponsored by Exelixis.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 20
- Enrollment target
- 2
- Study locations
NCT06962332 is a Phase 1 study of Hepatic Impairment and Moderate Hepatic Impairment that is actively recruiting participants, run by Exelixis. The registered enrollment target is 20 participants, below the 36-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (44% lower). The trial reports 2 study locations across 2 states.
The verdict
NCT06962332, a Phase 1 study of Hepatic Impairment and Moderate Hepatic Impairment, is actively recruiting participants, sponsored by Exelixis.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 20 participants
- Enrollment target
- 2
- Study locations
Study Summary
The primary purpose of this study is to evaluate the plasma PK of zanzalintinib following a single dose in participants with moderate liver dysfunction compared to matched healthy participants with normal liver function.
Conditions Studied
Interventions
- DRUG Zanzalintinib
Study Locations (2)
Florida
- Exelixis Clinical Site #1 - Orlando
Texas
- Exelixis Clinical Site #2 - San Antonio
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 20 participants |
| Start Date | 2025-05-13 |
| Est. Completion | 2026-04 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06962332
The ClinicalTrials.gov registry entry for NCT06962332 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 20 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 36-participant average among 48 other Hepatic Impairment trials with a reported enrollment target (44% lower). The listed sponsor is Exelixis, which has 48 total studies on file at ClinicalTrials.gov.
The record links to 2 conditions, with Hepatic Impairment appearing as the primary indexed condition, and to 1 intervention - of which Zanzalintinib is the first listed.
NCT06962332 reports 2 study locations spanning 2 distinct geographic areas - top geographies include Florida, Texas.
Frequently Asked Questions
What is clinical trial NCT06962332 about?
NCT06962332 is a clinical study titled "Pharmacokinetics (PK) and Safety of Zanzalintinib in Participants With Moderate Hepatic Impairment (HI)". The primary purpose of this study is to evaluate the plasma PK of zanzalintinib following a single dose in participants with moderate liver dysfunction compared to matched healthy participants with normal liver function.
What is the current status of trial NCT06962332?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 20 participants. The study started on 2025-05-13. Estimated completion is 2026-04.
What conditions does trial NCT06962332 study?
This clinical trial studies the following conditions: Hepatic Impairment, Moderate Hepatic Impairment.
What interventions are being tested in trial NCT06962332?
The interventions under investigation include: Zanzalintinib (DRUG).
Who is sponsoring clinical trial NCT06962332?
This trial is sponsored by Exelixis, which has 48 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06962332 being conducted?
This trial has 2 study locations across Florida, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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