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COMPLETED Phase 3

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma

NCT01865747 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to evaluate the effect of Cabozantinib (XL184) compared with Everolimus (Afinitor) on progression-free survival (PFS) and overall survival (OS) in subjects with advanced renal cell cancer that has progressed after prior VEGFR tyrosine kinase inhibitor therapy.

Conditions Studied

Interventions

  • DRUG Cabozantinib tablets
  • DRUG Everolimus (Afinitor) tablets

Study Locations (20)

California

  • — Duarte
  • — La Jolla
  • — Los Angeles
  • — Los Angeles
  • — Vallejo

Florida

  • — Boca Raton
  • — Miami
  • — Miami
  • — Orlando
  • — Tampa

Arizona

  • — Gilbert
  • — Scottsdale
  • — Tucson

Colorado

  • — Aurora
  • — Denver

Alabama

  • — Birmingham

Alaska

  • — Anchorage

Connecticut

  • — New Haven

District of Columbia

  • — Washington D.C.

Trial Details

FieldValue
Enrollment Target 658 participants
Start Date 2013-06
Est. Completion 2021-01-15
Phase Phase 3

Sponsor

Exelixis

54 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01865747

The ClinicalTrials.gov registry entry for NCT01865747 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 658 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Exelixis, which has 54 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Renal Cell Carcinoma appearing as the primary indexed condition, and to 2 interventions — of which Cabozantinib tablets is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01865747 reports 20 study locations spanning 9 distinct geographic areas — top geographies include California, Florida, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01865747 about?

NCT01865747 is a clinical study titled "A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma". The purpose of this study is to evaluate the effect of Cabozantinib (XL184) compared with Everolimus (Afinitor) on progression-free survival (PFS) and overall survival (OS) in subjects with advanced renal cell cancer that has progressed after prior VEGFR tyrosine kinase inhibitor therapy.

What is the current status of trial NCT01865747?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 658 participants. The study started on 2013-06. Estimated completion is 2021-01-15.

What conditions does trial NCT01865747 study?

This clinical trial studies the following conditions: Renal Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01865747?

The interventions under investigation include: Cabozantinib tablets (DRUG), Everolimus (Afinitor) tablets (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01865747?

This trial is sponsored by Exelixis, which has 54 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01865747 being conducted?

This trial has 20 study locations across Alabama, Alaska, Arizona, California, Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial