EMD Serono Research & Development Institute

81 total trials 9 currently recruiting 40 completed

EMD Serono Research & Development Institute sponsors 81 registered US clinical trials on ClinicalTrials.gov, 9 of them currently recruiting, and 40 completed. 17 of these trials are in Phase 3-4 (later-stage) and 58 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Advanced Solid Tumor, with 4 trials.

Trial Pipeline

81 total, page 1 of 2

RECRUITING Phase 3

A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)

NCT07549412

RECRUITING Phase 3

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)

NCT07355218

RECRUITING Phase 3

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

NCT07332481

RECRUITING Phase 1

Anti-Ly6E Exatecan ADC M7437 in Advanced Solid Tumors

NCT07360314

RECRUITING Phase 1

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

NCT07166601

RECRUITING Phase 1

Study of Anti-CEACAM5 ADC M9140 in Participants With Advanced Solid Tumors (PROCEADE PanTumor)

NCT06710132

RECRUITING Phase 1

Anti-GD2 ADC M3554 in Advanced Solid Tumors

NCT06641908

RECRUITING

Met Non Small Cell Cancer Registry (MOMENT)

NCT05376891

RECRUITING Phase 1

Anti-CEACAM5 ADC M9140 in Advanced Solid Tumors (PROCEADE-CRC-01)

NCT05464030

ACTIVE NOT RECRUITING Phase 2

Tuvusertib Combined With Niraparib or Lartesertib in Participants With Epithelial Ovarian Cancer (DDRiver EOC 302)

NCT06433219

ACTIVE NOT RECRUITING Phase 1

M9466 Alone or in Combination in Advanced Solid Tumors (DDriver 501)

NCT06421935

ACTIVE NOT RECRUITING Phase 1

Tuvusertib (M1774) in Combination With Cemiplimab in Participants With Non-Squamous NSCLC (DDRiver NSCLC 322)

NCT05882734

ACTIVE NOT RECRUITING Phase 2

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

NCT05327530

ACTIVE NOT RECRUITING Phase 1

Study of Tuvusertib (M1774) in Combination With DNA Damage Response Inhibitor or Immune Checkpoint Inhibitor (DDRiver Solid Tumors 320)

NCT05396833

ACTIVE NOT RECRUITING Phase 1

Tuvusertib (M1774) in Participants With Metastatic or Locally Advanced Unresectable Solid Tumors (DDRiver Solid Tumors 301)

NCT04170153

ACTIVE NOT RECRUITING Phase 2

A Study of Tepotinib Plus Osimertinib in Osimertinib Relapsed MET Amplified NSCLC (INSIGHT 2)

NCT03940703

ACTIVE NOT RECRUITING Phase 3

Avelumab Program Rollover Study

NCT03815643

ACTIVE NOT RECRUITING Phase 2

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

NCT02864992

COMPLETED Phase 1

A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants

NCT07097259

TERMINATED Phase 1

M9466 in Combination With Topoisomerase 1 Inhibitors-based Regimens in Advanced Solid Tumors and Colorectal Cancer (DDRiver 511)

NCT06509906

TERMINATED Phase 1

Phase 1b Safety Study of Xevinapant, Weekly Cisplatin, and RT in Participants With Unresected LA SCCHN (HyperlynX)

NCT06056310

TERMINATED Phase 2

Study of M5049 in DM and PM Participants (NEPTUNIA)

NCT05650567

TERMINATED Phase 3

Phase III Xevinapant (Debio 1143) and Radiotherapy in Resected LA SCCHN, High Risk, Cisplatin-ineligible Participants (XRAY VISION)

NCT05386550

COMPLETED Phase 2

The WILLOW Study With M5049 in SLE and CLE (SCLE and/or DLE) (WILLOW)

NCT05162586

TERMINATED Phase 1

First in Human Study of M1069 in Advanced Solid Tumors

NCT05198349

COMPLETED Phase 3

Bintrafusp Alfa Program Rollover Study

NCT05061823

TERMINATED

Next-Gen MS: Feed-forward PRO Data for MS Research

NCT04907305

COMPLETED Phase 1

First-in-human Study of M4076 in Advanced Solid Tumors (DDRiver Solid Tumors 410)

NCT04882917

COMPLETED Phase 2

Berzosertib + Topotecan in Relapsed Platinum-Resistant Small-Cell Lung Cancer (DDRiver SCLC 250)

NCT04768296

COMPLETED

The MS-LINK™ Outcomes Study

NCT04735406

TERMINATED Phase 2

Study of Tepotinib Combined With Cetuximab in Participants With Left-Sided RAS/BRAF Wild Type Metastatic Colorectal Cancer (PERSPECTIVE)

NCT04515394

COMPLETED Phase 1

M1231 in Participants With Solid Tumors

NCT04695847

COMPLETED Phase 1

Bintrafusp Alfa Combination Therapy in Participants With Cervical Cancer (INTR@PID 046)

NCT04551950

TERMINATED Phase 2

Bintrafusp Alfa in High Mobility Group AT-Hook 2 (HMGA2) Expressing Triple Negative Breast Cancer

NCT04489940

TERMINATED Phase 3

A Study of Xevinapant (Debio 1143) in Combination With Platinum-Based Chemotherapy and Standard Fractionation Intensity-Modulated Radiotherapy in Participants With Locally Advanced Squamous Cell Carcinoma of the Head and Neck, Suitable for Definitive Chemoradiotherapy (TrilynX)

NCT04459715

COMPLETED Phase 2

Study of M5049 in Participants With COVID-19 Pneumonia (ANEMONE)

NCT04448756

COMPLETED Phase 1

First in Human Study of M6223

NCT04457778

COMPLETED Phase 2

Bintrafusp Alfa Monotherapy in Platinum-Experienced Cervical Cancer

NCT04246489

TERMINATED Phase 1

First in Human Dose Escalation of M3258 as a Single Agent and Expansion Study of M3258 in Combination With Dexamethasone

NCT04075721

TERMINATED Phase 2

Gemcitabine Plus Cisplatin With or Without Bintrafusp Alfa (M7824) in Participants With 1L BTC

NCT04066491

TERMINATED Phase 3

Study of Evobrutinib in Participants With RMS

NCT04032171

TERMINATED Phase 3

Study of Evobrutinib in Participants With Relapsing Multiple Sclerosis (RMS)

NCT04032158

COMPLETED Phase 4

Long-Term Outcomes and Durability of Effect Following Treatment With Cladribine Tablets for MS (CLASSIC-MS)

NCT03961204

COMPLETED

A Study of Suboptimally Controlled Participants Previously Taking Oral or Infusion DMDs for RMS (MASTER-2)

NCT03933202

COMPLETED

A Study of Suboptimally Controlled Participants Previously Taking Injectable DMDs for RMS (CLICK-MS)

NCT03933215

TERMINATED Phase 2

M7824 With cCRT in Unresectable Stage III Non-small Cell Lung Cancer (NSCLC)

NCT03840902

COMPLETED Phase 1

M7824 in Combination With Chemotherapy in Stage IV Non-small Cell Lung Cancer (NSCLC)

NCT03840915

COMPLETED Phase 2

M7824 Monotherapy in Locally Advanced or Metastatic Second Line (2L) Biliary Tract Cancer (Cholangiocarcinoma and Gallbladder Cancer)

NCT03833661

COMPLETED Phase 1

Study of Peposertib in Combination With Capecitabine and RT in Rectal Cancer

NCT03770689

COMPLETED Phase 1

Phase Ib/II Study of Carboplatin + M6620 + Avelumab in PARPi-resistant Ovarian Cancer

NCT03704467

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What the Pipeline for EMD Serono Research & Development Institute Shows

According to the ClinicalTrials.gov registry, EMD Serono Research & Development Institute is linked to 81 US clinical trials across every stage of research activity. Of those, 9 studies are currently recruiting, about 11% of the sponsor's indexed portfolio, and 40 are already marked complete, representing roughly 49% of the total.

The phase mix for EMD Serono Research & Development Institute reports 17 late-stage studies (Phase 3 and Phase 4 combined) and 58 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for EMD Serono Research & Development Institute is Advanced Solid Tumor with 4 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.