Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

ACTIVE NOT RECRUITING Phase 2

Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)

NCT02864992 · View on ClinicalTrials.gov ↗

Study Summary

This study looked at how effective the study drug (tepotinib) was at stopping the growth and spread of lung cancer. This study also measures a number of other things including safety of the study drug and the side effects, how body processes the study drug, or how the study drug affects your quality of life. The study also has an optional pharmacogenetic research part. Pharmacogenetic research is an important way to try to understand the role of genetics in human disease and how genes impact the effectiveness of drugs, because differences in genes can change the way a person responds to a particular drug.

Interventions

  • DRUG Tepotinib

Study Locations (20)

California

  • City of Hope Cancer Center — Duarte
  • California Cancer Associates for Research & Excellence, Inc. — Encinitas
  • St. Joseph Hospital — Orange
  • Torrance Health Association — Redondo Beach
  • St Joseph Heritage Healthcare — Santa Rosa

Missouri

  • St. Louis Cancer Care, LLP — Bridgeton
  • Saint Louis University Cancer Center — St Louis
  • Saint Louis University — St Louis

Florida

  • Holy Cross Hospital Inc. — Fort Lauderdale
  • H. Lee Moffitt Cancer Center and Research Institute, Inc — Tampa

Georgia

  • University Cancer & Blood Center, LLC — Athens
  • Winship Cancer Institute — Atlanta

Illinois

  • University of Chicago Medical Center — Chicago
  • Ingalls Hospital — Harvey

New Jersey

  • Summit Medical Group, P.A. — Berkeley Heights
  • Summit Medical Group — Berkeley Heights

Colorado

  • Rocky Mountain Cancer Centers, LLP — Denver

Indiana

  • Community Regional Cancer Care — Indianapolis

Trial Details

FieldValue
Enrollment Target 337 participants
Start Date 2016-09-13
Est. Completion 2026-04-30
Phase Phase 2

Interested in This Trial?

Always speak with your doctor before enrolling in a clinical trial.

Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02864992

The ClinicalTrials.gov registry entry for NCT02864992 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 337 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is EMD Serono Research & Development Institute, which has 51 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 2 conditions, with Lung Adenocarcinoma Stage IIIB/IV appearing as the primary indexed condition, and to 1 intervention — of which Tepotinib is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02864992 reports 20 study locations spanning 10 distinct geographic areas — top geographies include California, Missouri, Florida. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02864992 about?

NCT02864992 is a clinical study titled "Tepotinib Phase II in NSCLC Harboring MET Alterations (VISION)". This study looked at how effective the study drug (tepotinib) was at stopping the growth and spread of lung cancer. This study also measures a number of other things including safety of the study drug and the side effects, how body processes the study drug, or how the study drug affects your quality...

What is the current status of trial NCT02864992?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 337 participants. The study started on 2016-09-13. Estimated completion is 2026-04-30.

What conditions does trial NCT02864992 study?

This clinical trial studies the following conditions: Lung Adenocarcinoma Stage IIIB/IV, Advanced (Stage IIIB/IV) Non-small Cell Lung Cancer (NSCLC) With MET Exon 14 (METex14) Skipping Alterations or MET Amplification. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02864992?

The interventions under investigation include: Tepotinib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02864992?

This trial is sponsored by EMD Serono Research & Development Institute, which has 51 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02864992 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Georgia, Illinois. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial