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ClinicalTrials.gov 5 recruiting now official registry

Relapsing Remitting Multiple Sclerosis clinical trials

5 of 27 indexed Relapsing Remitting Multiple Sclerosis trials are currently recruiting.

27 US clinical trials · 5 currently recruiting

Relapsing Remitting Multiple Sclerosis is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 5 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 7 in Phase 1-2 (earlier-stage). The most active sponsor is Biogen, running 3 of these trials.

The research picture

Relapsing Remitting Multiple Sclerosis has 27 registered US clinical trials, 5 of them open to new participants right now, about 19% of the total.

5
recruiting participants now
19%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
3
top sponsor: Biogen
Phase 14Phase 23Phase 34Phase 42

Active & Recent Trials

27 total, page 1 of 1

RECRUITING 500 participants

Study to Evaluate the Usability and Value of Integrated Digital Solutions in Medical Care of Participants With Multiple Sclerosis

Hoffmann-La Roche

NCT05949580

RECRUITING Phase 3 156 participants

Best Available Therapy Versus Autologous Hematopoietic Stem Cell Transplant for Multiple Sclerosis (BEAT-MS)

National Institute of Allergy and Infectious Diseases (NIAID)

NCT04047628

RECRUITING NA 100 participants

Functional Outcomes From Diets in Multiple Sclerosis

University of Alabama at Birmingham

NCT05327322

RECRUITING 80 participants

Exploratory Study on the Timing of Multiple Sclerosis (MS) Symptoms

University of Louisville

NCT00919217

RECRUITING NA 60 participants

The SetPoint System as a Pro-Remyelination Therapy for Relapsing-Remitting Multiple Sclerosis: A Pilot Study

SetPoint Medical Corporation

NCT06796504

ACTIVE NOT RECRUITING Phase 3 188 participants

A Study to Evaluate Safety and Efficacy of Ocrelizumab in Comparison With Fingolimod in Children and Adolescents With Relapsing-Remitting Multiple Sclerosis (RRMS)

Hoffmann-La Roche

NCT05123703

ACTIVE NOT RECRUITING Phase 4 136 participants

A Multicenter Study of Continued Current Therapy vs Transition to Ofatumumab After Neurofilament (NfL) Elevation

Novartis Pharmaceuticals

NCT05090371

ACTIVE NOT RECRUITING NA 44 participants

Clinically Isolated Syndrome and Relapsing-Remitting Multiple Sclerosis

Terry L. Wahls

NCT04009005

ACTIVE NOT RECRUITING 42 participants

Serum Neurofilament Light in Multiple Sclerosis

Dent Neuroscience Research Center

NCT06282081

ACTIVE NOT RECRUITING 40 participants

Reduced Oligodendrocyte-specific Cytotoxicity and Ofatumumab Treatment

University of Southern California

NCT05171972

ACTIVE NOT RECRUITING Phase 1 31 participants

WEBCAMS: Walking Exercise for Brain and Cognition in Adults With Multiple Sclerosis

Kessler Foundation

NCT05755061

COMPLETED Phase 3 1,234 participants

Efficacy and Safety of Oral BG00012 in Relapsing-Remitting Multiple Sclerosis

Biogen

NCT00420212

COMPLETED Phase 4 881 participants

Evaluation of Patient Retention of Fingolimod vs. Currently Approved Disease Modifying Therapy in Patients With Relapsing Remitting Multiple Sclerosis.

Novartis Pharmaceuticals

NCT01623596

COMPLETED Phase 3 506 participants

A Tolerability Study of ALKS 8700 in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS) EVOLVE-MS-2

Biogen

NCT03093324

COMPLETED Phase 2 297 participants

Safety, Tolerability, Efficacy and Optimal Dose Finding Study of BAF312 in Patients With Relapsing-remitting Multiple Sclerosis

Novartis Pharmaceuticals

NCT00879658

COMPLETED Phase 2 182 participants

Study to Evaluate the Safety and Efficacy of PIPE-307 in Subjects With Relapsing-Remitting Multiple Sclerosis

Contineum Therapeutics

NCT06083753

COMPLETED Phase 2 158 participants

A Combination Trial of Copaxone Plus Estriol in Relapsing Remitting Multiple Sclerosis (RRMS)

University of California, Los Angeles

NCT00451204

COMPLETED 113 participants

A Study to Assess the Effectiveness and Safety of Mayzent in Chinese Patients With Relapsing Forms of Multiple Sclerosis

Novartis

NCT06395909

COMPLETED NA 80 participants

Development of a Motivational Intervention to Improve Treatment Adherence in MS

University of Missouri, Kansas City

NCT01925690

COMPLETED Phase 1 47 participants

Safety Study of BIIB033 in Subjects With Multiple Sclerosis

Biogen

NCT01244139

COMPLETED 45 participants

Utilization of the Ketogenic Diet in Patient With Relapsing Remitting MS

University of Virginia

NCT03718247

COMPLETED 43 participants

Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab

Providence Health & Services

NCT03157830

COMPLETED 34 participants

Retrospective Study to Determine Effect of Rebif and Tecfidera on Infections and Lymphocytes

EMD Serono Research & Development Institute

NCT03284970

COMPLETED Early Phase 1 30 participants

Melatonin in Patients With Multiple Sclerosis (MS).

Providence Health & Services

NCT03498131

COMPLETED NA 30 participants

Tolerability of Acthar for the Treatment of Multiple Sclerosis in Relapses (TAMS)

OhioHealth

NCT02258217

COMPLETED 10 participants

Glatiramer Acetate for Multiple Sclerosis With Autoimmune Comorbidities

University of Southern California

NCT01456416

COMPLETED Phase 1

Vitamin D Pilot Study in Patients With Multiple Sclerosis

University of Wisconsin, Madison

NCT01257958

Phase Distribution

PhaseTrial count
Phase 1 4
Phase 2 3
Phase 3 4
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Relapsing Remitting Multiple Sclerosis Trial Landscape

27 indexed Relapsing Remitting Multiple Sclerosis studies · 5 recruiting (19%).

Phase mix: 6 late (III/IV) vs 7 early (I/II).

Top sponsor: Biogen (3 trials), 9 others listed. 27 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Relapsing Remitting Multiple Sclerosis?

PlainTrial tracks 27 US clinical trials for Relapsing Remitting Multiple Sclerosis, of which 5 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Relapsing Remitting Multiple Sclerosis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.