Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 31 recruiting now official registry

Weight Loss clinical trials

31 of 119 indexed Weight Loss trials are currently recruiting.

119 US clinical trials · 31 currently recruiting

Weight Loss is the subject of 119 registered US clinical trials on ClinicalTrials.gov, 31 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 15 in Phase 1-2 (earlier-stage). The most active sponsor is Drexel University, running 4 of these trials.

The research picture

Weight Loss has 119 registered US clinical trials, 31 of them open to new participants right now, about 26% of the total.

31
recruiting participants now
26%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
4
top sponsor: Drexel University
Phase 13Phase 212Phase 32Phase 43

Active & Recent Trials

119 total, page 2 of 3

ACTIVE NOT RECRUITING Phase 4 40 participants

Lorcaserin in Obesity: Identification of CNS Targets Using FMRI

Beth Israel Deaconess Medical Center

NCT02400359

ACTIVE NOT RECRUITING NA 40 participants

Evaluation of the Effects of a Biostimulator and Dermal Fillers for Cheek Augmentation and Contour Deficiencies

Galderma R&D

NCT06351358

ACTIVE NOT RECRUITING NA 30 participants

Healthy Eating Patterns During a Lifestyle Intervention

The University of Tennessee, Knoxville

NCT01682317

ACTIVE NOT RECRUITING NA 30 participants

Hepatic Energy Fluxes in NASH and NAS Patients

University of Minnesota

NCT03997422

ACTIVE NOT RECRUITING 21 participants

WeighT LOSS Surgery and Comprehensive Cardiometabolic Responses to to EXercise

Massachusetts General Hospital

NCT06576050

ACTIVE NOT RECRUITING NA 20 participants

Evaluation of Bariatric Endoscopic Antral Myotomy (BEAM) as a Treatment for Obesity

Brigham and Women's Hospital

NCT05713071

COMPLETED NA 2,395 participants

Weight Management Demonstration Project: HEALTH

RTI International

NCT01307280

COMPLETED NA 974 participants

Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes

NYU Langone Health

NCT03188094

COMPLETED 588 participants

Health Outcomes After Participating in Exercise (HOPE)

Wake Forest University Health Sciences

NCT03430115

COMPLETED NA 430 participants

Gestational Weight Gain and Postpartum Weight Loss in Active Duty Women (Moms Fit 2 Fight)

University of Tennessee

NCT03057808

COMPLETED NA 373 participants

Study of an International Commercial Program on Weight Loss and Health Outcomes

University of North Carolina, Chapel Hill

NCT03571893

COMPLETED NA 360 participants

Delicious Eating for Life in Southern Homes

University of North Carolina, Chapel Hill

NCT04302727

COMPLETED NA 296 participants

Rural Disparities in Pediatric Obesity: The iAmHealthy Intervention

University of Kansas Medical Center

NCT03304249

COMPLETED Phase 1 294 participants

Effect of Exercise on Prevention of Weight Gain

University of Pittsburgh

NCT00177502

COMPLETED NA 288 participants

Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain

Abramson Cancer Center at Penn Medicine

NCT02906787

COMPLETED NA 287 participants

A Randomized Trial of Recommendations for Exercise to Prevent Weight Regain

University of Kansas

NCT01664715

COMPLETED Phase 2 280 participants

VK2735 for Weight Management Phase 2 (Venture Oral Dosing)

Viking Therapeutics

NCT06828055

COMPLETED NA 276 participants

Project Activate: Mindfulness and Acceptance Based Behavioral Treatment for Weight Loss

Drexel University

NCT04337619

COMPLETED NA 187 participants

Weight Management in Rural Communities

University of Kansas

NCT02932748

COMPLETED NA 176 participants

Spark: Finding the Optimal Tracking Strategy for Weight Loss in a Digital Health Intervention

Stanford University

NCT05249465

COMPLETED Phase 1 174 participants

A Mentor-Based Approach to Long-Term Weight Loss

University of Pittsburgh

NCT00177697

COMPLETED 157 participants

Lorcaserin: Real World Experience in an Insurance-Based Weight Management Clinic

Scripps Whittier Diabetes Institute

NCT03552107

COMPLETED NA 153 participants

Single Arm Trial of a Multi-component Commercial Digital Weight Loss Program

University of Connecticut

NCT04302389

COMPLETED NA 134 participants

Facebook and Friends: Developing an Effective Online Social Network for Weight Loss

University of Connecticut

NCT02656680

COMPLETED NA 132 participants

University Of Pennsylvania Weight Loss Study

University of Pennsylvania

NCT01167634

COMPLETED NA 120 participants

A Study to Evaluate the Effect of SlimBiotics Probiotic Formula on Weight Management and Metabolic Health Outcomes

Slimbiotics

NCT05917314

COMPLETED NA 107 participants

Bitter Taste and Weight Loss in Women

Rutgers University

NCT01856660

COMPLETED NA 106 participants

Partners at Meals - Respite Care and Home (PAM)

Medical University of South Carolina

NCT03622814

COMPLETED NA 102 participants

Healthy Body Healthy Souls in the Marshallese Population

University of Arkansas

NCT03377244

COMPLETED 97 participants

The Collateral Impact of Bariatric Surgery on Families

Geisinger Clinic

NCT02021630

COMPLETED NA 80 participants

The Role of High Intensity Interval Training in the Treatment of Adolescent Obesity

Virginia Commonwealth University

NCT03361644

COMPLETED NA 80 participants

Impact of Volunteer Peer-Led Intervention for Weight Control in Primary Care

Milton S. Hershey Medical Center

NCT01850550

COMPLETED NA 79 participants

Evaluation of Ovarian Morphology and Function in Overweight Women During Weight Loss

Cornell University

NCT01785719

COMPLETED NA 77 participants

Phone Coaching for Weight Loss Maintenance

The Miriam Hospital

NCT04293055

COMPLETED NA 75 participants

A Comparative Effectiveness Study Evaluating the Effects of Thermogenic Supplements on Body Composition

Integrative Health Technologies

NCT01423019

COMPLETED NA 72 participants

Effect of Soy Protein and Colorado Diet on Weight Loss and Maintenance

DuPont Nutrition and Health

NCT02380963

COMPLETED Phase 2 66 participants

Healthy4Baby: Preventing Postpartum Weight Retention Among Low-Income, Black Women

Temple University

NCT01530776

COMPLETED NA 62 participants

Helping Employees Lose Pounds

University of Michigan

NCT02853877

COMPLETED NA 60 participants

The Effect of Weight Loss and Dietary Protein Intake on Bone

Rutgers University

NCT00473031

COMPLETED NA 60 participants

OA Clinic-Community CARE Model

University of North Carolina, Chapel Hill

NCT05349500

COMPLETED NA 60 participants

Effects of Lactobacillus Plantarum KABP-51 Probiotic on Body Composition, Microbiome and Mood in Healthy Overweight Adults

3 Waves Wellness

NCT06808061

COMPLETED NA 60 participants

Effects of Human Milk Oligosaccharide Ingestion on Weight Loss and Markers of Health

Advanced Protein Technologies Corporation

NCT06547801

COMPLETED NA 60 participants

Active Nutrition Program on Weight Loss

University of Memphis

NCT06249698

COMPLETED NA 50 participants

Esophageal Cytology With FISH in Detecting Esophageal Cancer

OHSU Knight Cancer Institute

NCT02100189

COMPLETED NA 48 participants

Eating Mindfully to Prevent Weight Regain

University of Utah

NCT04847843

COMPLETED NA 45 participants

ObeSity and Jobs in SoCioeconomically Disadvantaged CommUnities: A Randomized CLinical Precision Public HealTh Intervention --The SCULPT-Job Study

University of California, San Francisco

NCT04709549

COMPLETED NA 43 participants

Intermittent Fasting, Caloric Restriction and Body Composition in Obese Men and Women

Skidmore College

NCT02525419

COMPLETED NA 42 participants

Effects of Dietary Protein on Musculoskeletal Health During Calorie Deficiency

United States Army Research Institute of Environmental Medicine

NCT01292395

COMPLETED Phase 4 41 participants

Examining the Effect of Ondansetron on Bowel Prep Success

State University of New York - Downstate Medical Center

NCT05439772

COMPLETED NA 40 participants

Sleep Goal-focused Online Access to Lifestyle Support

University of Pittsburgh

NCT05942326

← Previous Page 2 of 3 Next →

Phase Distribution

PhaseTrial count
Phase 1 3
Phase 2 12
Phase 3 2
Phase 4 3

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Weight Loss Trial Landscape

119 indexed Weight Loss studies · 31 recruiting (26%).

Phase mix: 5 late (III/IV) vs 15 early (I/II).

Top sponsor: Drexel University (4 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Weight Loss?

PlainTrial tracks 119 US clinical trials for Weight Loss, of which 31 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Weight Loss?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.