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ClinicalTrials.gov 45 recruiting now official registry

Ulcerative Colitis clinical trials

45 of 123 indexed Ulcerative Colitis trials are currently recruiting.

123 US clinical trials · 45 currently recruiting

Ulcerative Colitis is the subject of 123 registered US clinical trials on ClinicalTrials.gov, 45 of them currently open to new participants. 32 are in Phase 3-4 (later-stage) and 47 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 9 of these trials.

The research picture

Ulcerative Colitis has 123 registered US clinical trials, 45 of them open to new participants right now, about 37% of the total.

45
recruiting participants now
37%
of trials open to enrollment
32
in Phase 3–4 (later-stage)
9
top sponsor: Eli Lilly and Company
Phase 115Phase 232Phase 328Phase 44

Active & Recent Trials

123 total, page 3 of 3

COMPLETED Phase 2 59 participants

Long-term Safety With Vedolizumab Intravenous (IV) in Pediatric Participants With Ulcerative Colitis (UC) or Crohn's Disease (CD)

Takeda

NCT03196427

COMPLETED NA 55 participants

A Comprehensive Self-Management Intervention for Individuals With Inflammatory Bowel Disease

University of Washington

NCT05651542

COMPLETED NA 55 participants

Intestinal Ultrasound for the Evaluation of Pouchitis and Other Outcomes After Ileal Pouch-Anal Anastomosis

Mayo Clinic

NCT06316999

COMPLETED NA 55 participants

Ulcerative Colitis Relapse Prevention Trial, Hypnosis

Northwestern University

NCT00798642

COMPLETED Phase 1 55 participants

Mind/Body Medicine and IBD Flare-Up

Rush University Medical Center

NCT00568256

COMPLETED Phase 1 48 participants

A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of rhuMAb Beta7 in Patients With Ulcerative Colitis

Genentech

NCT00694980

COMPLETED NA 45 participants

SMART-IBD App Trial

Children's Hospital Medical Center, Cincinnati

NCT06023667

COMPLETED Phase 1 43 participants

Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 181.

Amgen

NCT01290042

COMPLETED Phase 1 39 participants

Safety, Tolerability, and Pharmacokinetics of Oral NX-13 in Active Ulcerative Colitis

Landos Biopharma

NCT04862741

COMPLETED Phase 2 38 participants

Efficacy and Safety of Orally Administered BBT-401-1S in Subjects With Ulcerative Colitis

Bridge Biotherapeutics

NCT04596293

COMPLETED Phase 1 33 participants

Evaluation of an Oral Anti-TNF Antibody in Patients With Active Ulcerative Colitis

Avaxia Biologics, Incorporated

NCT01759056

COMPLETED NA 31 participants

Protein Metabolism in Newly Diagnosed Pediatric Inflammatory Bowel Disease

Indiana University

NCT00586352

COMPLETED NA 30 participants

Transcutaneous VNS to Treat Pediatric IBD

Northwell Health

NCT03863704

COMPLETED NA 30 participants

Digital Behavioral Interventions in Inflammatory Bowel Disease

Montefiore Medical Center

NCT04861597

COMPLETED Phase 1 27 participants

Safety and Pharmacokinetics Study of HE3286 in Patients With Active, Mild-to-Moderate Ulcerative Colitis

Harbor Therapeutics

NCT00628433

COMPLETED Phase 2 26 participants

A Study of Mirikizumab (LY3074828) in Children and Teenagers With Ulcerative Colitis (UC)

Eli Lilly and Company

NCT04004611

COMPLETED Phase 1 26 participants

Fecal Transplant for Ulcerative Colitis

University of Minnesota

NCT03948919

COMPLETED Phase 1 24 participants

A Dose-Escalation Study of MDX-1100 in Patients With Active Ulcerative Colitis

Bristol-Myers Squibb

NCT00295282

COMPLETED NA 23 participants

Broccoli Sprouts for Mild Ulcerative Colitis

University of Michigan

NCT05507931

COMPLETED NA 20 participants

Anti-Inflammatory Effects of Mango Polyphenolics in Inflammatory Bowel Disease

Texas A&M University

NCT02227602

COMPLETED Phase 2 18 participants

Interferon-beta1a (AVONEX) Treatment of Ulcerative Colitis

National Institute of Allergy and Infectious Diseases (NIAID)

NCT00048347

COMPLETED Phase 1 15 participants

Fecal Microbiota Transplant (FMT) in Pediatric Active Ulcerative Colitis and Pediatric Active Crohn's Colitis

Stacy A. Kahn

NCT02330653

COMPLETED Phase 1 6 participants

Oral OKT3 for the Treatment of Active Ulcerative Colitis

Brigham and Women's Hospital

NCT01287195

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Phase Distribution

PhaseTrial count
Phase 1 15
Phase 2 32
Phase 3 28
Phase 4 4

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Ulcerative Colitis Trial Landscape

123 indexed Ulcerative Colitis studies · 45 recruiting (37%).

Phase mix: 32 late (III/IV) vs 47 early (I/II).

Top sponsor: Eli Lilly and Company (9 trials), 9 others listed. 23 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Ulcerative Colitis?

PlainTrial tracks 123 US clinical trials for Ulcerative Colitis, of which 45 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Ulcerative Colitis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.