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Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis
NCT06290934 · View on ClinicalTrials.gov ↗
Study Summary
The goal of this study is to learn if GS-1427 is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with GS-1427 with participants treated with placebo. The primary objective of this study is to assess the efficacy of GS-1427, compared with placebo control, in achieving clinical response at Week 12.
Conditions Studied
Interventions
- DRUG GS-1427
- DRUG Placebo-to-match GS-1427
Study Locations (20)
California
- Om Research LLC — Camarillo
- VVCRD Research — Garden Grove
- 310 Clinical Research — Inglewood
- US San Diego Health System — La Jolla
- Om Research LLC — Lancaster
- UCSF Benioff Children's Hospital Oakland — Oakland
- University Of California, Davis — Sacramento
- SDG Clinical Research, LLC — San Diego
- Acclaim Clinical Research — San Diego
Florida
- Gastro Florida — Clearwater
- Best Quality Research, Inc — Hialeah
- United Research Institute LLC — Hialeah
- University of Miami Hospital and Clinics, Sylvester Comprehensive Cancer Center(Drug shipment)-Research Pharmacy — Miami
- Medical Professional Clinical Research Center, Inc. — Miami
- Blessed Health Care & Research, Inc — Miami
- Alliance Clinical Research of Tampa, LLC — New Port Richey
- Digestive and Liver Center of Florida, LLC — Orlando
Colorado
- Peak Gastroenterology Associates — Colorado Springs
- Peak Gastroenterology Associates — Colorado Springs
Arizona
- Onyx Clinical Research (Clinic Location) — Peoria
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 228 participants |
| Start Date | 2024-03-27 |
| Est. Completion | 2028-04 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06290934
The ClinicalTrials.gov registry entry for NCT06290934 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 228 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Gilead Sciences, which has 190 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Ulcerative Colitis appearing as the primary indexed condition, and to 2 interventions — of which GS-1427 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06290934 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Florida, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06290934 about?
NCT06290934 is a clinical study titled "Study of GS-1427 in Participants With Moderately to Severely Active Ulcerative Colitis". The goal of this study is to learn if GS-1427 is effective in treating participants with moderate to severe ulcerative colitis. The study will compare participants in different treatment groups treated with GS-1427 with participants treated with placebo. The primary objective of this study is to as...
What is the current status of trial NCT06290934?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 228 participants. The study started on 2024-03-27. Estimated completion is 2028-04.
What conditions does trial NCT06290934 study?
This clinical trial studies the following conditions: Ulcerative Colitis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06290934?
The interventions under investigation include: GS-1427 (DRUG), Placebo-to-match GS-1427 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06290934?
This trial is sponsored by Gilead Sciences, which has 190 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06290934 being conducted?
This trial has 20 study locations across Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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