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Type 1 Diabetes: early-phase trial registry
79 of 199 indexed Type 1 Diabetes trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #50 of 28,707 conditions by registered trial count.
199 US clinical trials · 79 currently recruiting · #50 of 28,707 conditions by registered trial count
Type 1 Diabetes: 199 US clinical trials tracked, 79 recruiting.
Type 1 Diabetes is the subject of 199 registered US clinical trials on ClinicalTrials.gov, 79 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 54 in Phase 1-2 (earlier-stage). The most active sponsor is University of Colorado, Denver, running 16 of these trials.
Enrollment posture brief
Registry condition type-1-diabetes
OPEN 79 | RECR 40% | LATE 21 | EARLY 54 | RANK #50 | SPON 16
Volume-matched condition peers
Nearest open-share peer: Pregnancy (40% recruiting · 194 trials)
Type 1 Diabetes lists 79 open slots (40% of 199 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Type 1 Diabetes on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Type 1 Diabetes is recruiting above its size-band peers.
79 of 199 indexed trials (39.7%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Type 1 Diabetes trials is spread across many organizations.
University of Colorado, Denver accounts for 16 of 199 trials (8%). 97 distinct sponsors appear on at least one study for this condition label.
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Most Type 1 Diabetes trials plan to enrol fewer than 100 people.
Median target enrolment is 43 among the 199 trials that report a genuine target (sentinel values excluded). 141 of those (70.9%) plan for fewer than 100 participants.
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Type 1 Diabetes research is mostly interventional.
169 interventional and 30 observational studies make up this index (84.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
199 total, page 4 of 4
The Pediatric Artificial Pancreas Automated Initialization Trial
Marc Breton
NCT06017089
Selecting Insulin Analogs for Closed-Loop Control Using Multiplex Pharmacokinetic Profiling
Massachusetts General Hospital
NCT01684943
MyT1DHero: an mHealth Intervention for Type 1 Diabetes
Michigan State University
NCT03521362
The Impact of Fitness and Mineralocorticoid Receptor Blockade on Vascular Dysfunction in Adults With Type 1 Diabetes
University of Virginia
NCT03174288
Pilot Study 3 of Outpatient Control-to-Range: Safety and Efficacy With Day-and-Night In-Home Use
Jaeb Center for Health Research
NCT02137512
Context Aware Data Gathering Study
Oregon Health and Science University
NCT04154904
Effects of Acipimox on Insulin Action, Vascular Function, and Muscle Function in Type 1 Diabetes
University of Colorado, Denver
NCT01816165
The Monitoring Study
Massachusetts General Hospital
NCT02969863
Primary Intervention With Mucosal Insulin
University of Colorado, Denver
NCT02620553
Assessment of a Decision Support Tool in Participants With Type 1 Diabetes
Oregon Health and Science University
NCT04428645
Two Way Crossover Closed Loop Study MPC vs FMPD
Oregon Health and Science University
NCT04771403
The Set-Point Study: Evaluating Effects of Changing Glucose Target on Bionic Pancreas Performance
Massachusetts General Hospital
NCT02509065
Digital Exercise for Middle-Aged Adults With Type 1 Diabetes and Other Absolute Insulin Deficiency Diabetes
Yale University
NCT06098729
A Study of Rapid-Acting Mealtime Insulin in Children and Adolescents With Newly Diagnosed Type 1 Diabetes Mellitus
Emory University
NCT04157738
Evaluation of Extended Infusion Set Wear Using Medtronic Extended Wear Sof-set Infusion Set
Stanford University
NCT02687256
Three-way, Cross-over Closed-loop Exercise Study
Oregon Health and Science University
NCT02241889
A Pilot Study to Assess the Glucose Lowering Effect of Metformin and Sitagliptin in Adolescents With Type 1 Diabetes
Baylor College of Medicine
NCT01718093
Reactive Oxygen Species in the Pathogenesis of Diabetic Complications
Albert Einstein College of Medicine
NCT00703989
Immune Effects of Vedolizumab With or Without Anti-TNF Pre-treatment in T1D
Benaroya Research Institute
NCT05281614
An Outpatient Pump Shutoff Pilot Feasibility and Safety Study
Jaeb Center for Health Research
NCT01736930
The Effect of Prolonged Pramlintide Infusion in Pediatric Diabetes
Baylor College of Medicine
NCT00206297
Web-Based Simulation Tool For Self-Management Support In Type 1 Diabetes Mellitus
University of Virginia
NCT04439903
Study of the Acute Metabolic Effect of Exenatide in Type 1 Diabetes
Yale University
NCT01855490
Support Group Surveys for Individuals Who Have Type 1 Diabetes and an Eating Disorder
HealthPartners Institute
NCT00818142
Evaluating the Benefits of Physiologic Insulin Delivery
Stanford University
NCT04416737
Evaluation of The Postprandial Impact of Automated Priming Bolus for Full Closed Loop Insulin Delivery
Marc Breton
NCT05528770
Cord Blood Plus Vitamin D and Omega 3s in T1D
University of Florida
NCT00873925
Artificial Pancreas With Different Stress Assessments in the Outpatient Setting
Sansum Diabetes Research Institute
NCT04142229
Sensor-Augmented Insulin Delivery: Insulin Plus Glucagon Versus Insulin Alone
Legacy Health System
NCT00797823
Islet Transplantation in Type 1 Diabetic Patients
University of Wisconsin, Madison
NCT00214253
Use of Continuous Glucose Monitoring System With Intensive Feedback in Adolescents With Poorly Controlled Type 1 Diabetes
NYU Langone Health
NCT03020069
Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy
Yale University
NCT01945099
Effect of Prebiotics on the Gut Microbiome Profile and Beta Cell Function
Indiana University
NCT04114357
Combination GRA and SGLT-2i Treatment in Type 1 Diabetes
University of California, San Diego
NCT04545411
Pilot Study of Closed-Loop Glucose Control in People With Type 1 Diabetes (BPK004)
University of Virginia
NCT00977808
Exercise and Diabetes - an Observational Study of Exercise and Blood Glucose Control
Sansum Diabetes Research Institute
NCT02190669
Measurement of Glucose/Glycogen Metabolism in Humans Using Magnetic Resonance at 4 or 7 Tesla
University of Minnesota
NCT00786825
Effect of Canagliflozin in T1DM (Type 1 Diabetes Melitus) After Interruption of Continuous Subcutaneous Insulin Infusion
Yale University
NCT02673138
Autologous Dendritic Cell Therapy for Type 1 Diabetes Suppression: A Safety Study
University of Pittsburgh
NCT00445913
Pramlintide in Adolescents With Type 1 Diabetes
University of Colorado, Denver
NCT00842075
Evaluation of Coffee Therapy for Improvement of Renal Oxygenation
University of Colorado, Denver
NCT03878277
Hybrid Closed Loop Insulin Delivery System in Hypoglycemia
University of Pennsylvania
NCT03215914
Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
Massachusetts General Hospital
NCT01527981
Safety and Feasibility of a Low Carbohydrate Diet in Children With Type 1 Diabetes
Washington University School of Medicine
NCT04228822
Pilot Study to Determine Effects of Salsalate in Type 1 Diabetes and Painful Peripheral Neuropathy
University of Michigan
NCT01480297
Pharmacokinetics (PK)/ Pharmacodynamics (PD) of an Extended Wear Infusion Set for Continuous Subcutaneous Insulin Infusion (CSII) in Type 1 Diabetes Mellitus (T1DM) Patients ("PEXIS")
Capillary Biomedical
NCT04398030
hOKT3γ1 (Ala-Ala) Combined With Sirolimus and Delayed Tacrolimus in Type 1 Diabetic Islet Allograft Recipients
University of Minnesota
NCT00285194
Liraglutide in Adolescents With Type 1 Diabetes
University at Buffalo
NCT02516657
Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients
Yale University
NCT03666065
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 30 |
| Phase 2 | 24 |
| Phase 3 | 11 |
| Phase 4 | 10 |
Top Sponsors
Named interventions
Most-linked intervention names on Type 1 Diabetes records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Type 1 Diabetes trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Type 1 Diabetes page
199 registered trials, 79 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 79 Type 1 Diabetes trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of Colorado, Denver sponsors the most Type 1 Diabetes trials on record, review their full trial history before evaluating a specific study. See University of Colorado, Denver's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Type 1 Diabetes condition card totals 199 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.