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Smoking clinical trials
27 of 124 indexed Smoking trials are currently recruiting.
124 US clinical trials · 27 currently recruiting
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
The research picture
Smoking has 124 registered US clinical trials, 27 of them open to new participants right now, about 22% of the total.
- 27
- recruiting participants now
- 22%
- of trials open to enrollment
- 13
- in Phase 3–4 (later-stage)
- 9
- top sponsor: RAI Services Company
Active & Recent Trials
124 total, page 3 of 3
Combination SBIRT for Emergency Department Patients Who Drink and Smoke
Yale University
NCT01595178
Tumor Markers in Lung Cancer: DCAMLK-1LK-1
University of Oklahoma
NCT01578018
Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics
University of North Carolina, Chapel Hill
NCT01663298
Integrative-omics of the Disordered COPD Small Airway Epithelium
Weill Medical College of Cornell University
NCT02183818
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
RAI Services Company
NCT05294497
Effects of Smoking Environment on Craving and Smoking
Duke University
NCT02416986
Modern Nicotine Oral Product Abuse Liability
RAI Services Company
NCT06777784
Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents (smokeScreen)
Yale University
NCT03722888
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Dartmouth-Hitchcock Medical Center
NCT04481737
A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers
GlaxoSmithKline
NCT01702519
Acute Effects of TCIG vs ECIG in PLWH
University of California, Los Angeles
NCT04568395
CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12
RAI Services Company
NCT05239884
Electronic Hookah and Endothelial Cell Function
University of California, Los Angeles
NCT04133376
Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Medical University of South Carolina
NCT03311646
The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse
Yale University
NCT00773422
Salt-Based E-cigarette
Medical University of South Carolina
NCT04238832
Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV
Kaiser Permanente
NCT05339659
Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
H. Lee Moffitt Cancer Center and Research Institute
NCT05362318
BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
RAI Services Company
NCT06105424
Sensory Perception of Sweet Flavors in E-Cigarette
Oregon State University
NCT03332953
E-cigarette Nicotine Pharmacokinetic Study
British American Tobacco (Investments) Limited
NCT03178981
E-cigarettes for Harm Reduction in Adults With Asthma
Brown University
NCT05278065
Galantamine Effects on Nicotine Responses in Smokers
Yale University
NCT01417429
A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis
Northwell Health
NCT01399112
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Trial Landscape
124 indexed Smoking studies · 27 recruiting (22%).
Phase mix: 13 late (III/IV) vs 22 early (I/II).
Top sponsor: RAI Services Company (9 trials), 9 others listed. 24 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking?
PlainTrial tracks 124 US clinical trials for Smoking, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.