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ClinicalTrials.gov 27 recruiting now official registry

Smoking clinical trials

27 of 124 indexed Smoking trials are currently recruiting.

124 US clinical trials · 27 currently recruiting

Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.

The research picture

Smoking has 124 registered US clinical trials, 27 of them open to new participants right now, about 22% of the total.

27
recruiting participants now
22%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
9
top sponsor: RAI Services Company
Phase 19Phase 213Phase 34Phase 49

Active & Recent Trials

124 total, page 3 of 3

COMPLETED Early Phase 1 50 participants

Combination SBIRT for Emergency Department Patients Who Drink and Smoke

Yale University

NCT01595178

COMPLETED NA 49 participants

Tumor Markers in Lung Cancer: DCAMLK-1LK-1

University of Oklahoma

NCT01578018

COMPLETED 44 participants

Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics

University of North Carolina, Chapel Hill

NCT01663298

COMPLETED 42 participants

Integrative-omics of the Disordered COPD Small Airway Epithelium

Weill Medical College of Cornell University

NCT02183818

COMPLETED NA 42 participants

CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches

RAI Services Company

NCT05294497

COMPLETED NA 41 participants

Effects of Smoking Environment on Craving and Smoking

Duke University

NCT02416986

COMPLETED NA 40 participants

Modern Nicotine Oral Product Abuse Liability

RAI Services Company

NCT06777784

COMPLETED NA 40 participants

Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents (smokeScreen)

Yale University

NCT03722888

COMPLETED NA 40 participants

Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery

Dartmouth-Hitchcock Medical Center

NCT04481737

COMPLETED Phase 1 40 participants

A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers

GlaxoSmithKline

NCT01702519

COMPLETED NA 37 participants

Acute Effects of TCIG vs ECIG in PLWH

University of California, Los Angeles

NCT04568395

COMPLETED NA 36 participants

CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12

RAI Services Company

NCT05239884

COMPLETED NA 33 participants

Electronic Hookah and Endothelial Cell Function

University of California, Los Angeles

NCT04133376

COMPLETED NA 31 participants

Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking

Medical University of South Carolina

NCT03311646

COMPLETED Phase 2 30 participants

The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse

Yale University

NCT00773422

COMPLETED NA 24 participants

Salt-Based E-cigarette

Medical University of South Carolina

NCT04238832

COMPLETED NA 22 participants

Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV

Kaiser Permanente

NCT05339659

COMPLETED NA 21 participants

Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free

H. Lee Moffitt Cancer Center and Research Institute

NCT05362318

COMPLETED NA 21 participants

BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability

RAI Services Company

NCT06105424

COMPLETED NA 19 participants

Sensory Perception of Sweet Flavors in E-Cigarette

Oregon State University

NCT03332953

COMPLETED NA 18 participants

E-cigarette Nicotine Pharmacokinetic Study

British American Tobacco (Investments) Limited

NCT03178981

COMPLETED NA 17 participants

E-cigarettes for Harm Reduction in Adults With Asthma

Brown University

NCT05278065

COMPLETED Phase 1 12 participants

Galantamine Effects on Nicotine Responses in Smokers

Yale University

NCT01417429

COMPLETED NA 11 participants

A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis

Northwell Health

NCT01399112

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Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 13
Phase 3 4
Phase 4 9

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Smoking Trial Landscape

124 indexed Smoking studies · 27 recruiting (22%).

Phase mix: 13 late (III/IV) vs 22 early (I/II).

Top sponsor: RAI Services Company (9 trials), 9 others listed. 24 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Smoking?

PlainTrial tracks 124 US clinical trials for Smoking, of which 27 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Smoking?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.