Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Smoking: early-phase trial registry
27 of 124 indexed Smoking trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #96 of 28,707 conditions by registered trial count.
124 US clinical trials · 27 currently recruiting · #96 of 28,707 conditions by registered trial count
Smoking: 124 US clinical trials tracked, 27 recruiting.
Smoking is the subject of 124 registered US clinical trials on ClinicalTrials.gov, 27 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is RAI Services Company, running 9 of these trials.
Enrollment posture brief
Registry condition smoking
OPEN 27 | RECR 22% | LATE 13 | EARLY 22 | RANK #96 | SPON 9
Volume-matched condition peers
Nearest open-share peer: Plaque Psoriasis (22% recruiting · 46 trials)
Smoking lists 27 open slots (22% of 124 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking is recruiting below its size-band peers.
27 of 124 indexed trials (21.8%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking trials is spread across many organizations.
RAI Services Company accounts for 9 of 124 trials (7.3%). 62 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking enrolment sits around 165 participants.
Median target enrolment is 165 among the 124 trials that report a genuine target (sentinel values excluded). 48 of those (38.7%) plan for fewer than 100 participants.
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Smoking research is mostly interventional.
113 interventional and 11 observational studies make up this index (91.1% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
124 total, page 3 of 3
Combination SBIRT for Emergency Department Patients Who Drink and Smoke
Yale University
NCT01595178
Tumor Markers in Lung Cancer: DCAMLK-1LK-1
University of Oklahoma
NCT01578018
Gene Expression Variation and Implant Wound Healing Among Smokers and Diabetics
University of North Carolina, Chapel Hill
NCT01663298
Integrative-omics of the Disordered COPD Small Airway Epithelium
Weill Medical College of Cornell University
NCT02183818
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
RAI Services Company
NCT05294497
Effects of Smoking Environment on Craving and Smoking
Duke University
NCT02416986
Modern Nicotine Oral Product Abuse Liability
RAI Services Company
NCT06777784
Development of a Videogame Prototype Targeting Cigarette and Marijuana Smoking, and Tobacco Product Prevention Among Young Adolescents (smokeScreen)
Yale University
NCT03722888
Peer-delivered and Technology-Assisted Integrated Illness Management and Recovery
Dartmouth-Hitchcock Medical Center
NCT04481737
A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers
GlaxoSmithKline
NCT01702519
Acute Effects of TCIG vs ECIG in PLWH
University of California, Los Angeles
NCT04568395
CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12
RAI Services Company
NCT05239884
Electronic Hookah and Endothelial Cell Function
University of California, Los Angeles
NCT04133376
Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking
Medical University of South Carolina
NCT03311646
The Effect of Naltrexone and Varenicline on Alcohol-Mediated Smoking Lapse
Yale University
NCT00773422
Salt-Based E-cigarette
Medical University of South Carolina
NCT04238832
Randomized Pilot Study of a mHealth App for Ambivalent Smokers Living With HIV
Kaiser Permanente
NCT05339659
Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
H. Lee Moffitt Cancer Center and Research Institute
NCT05362318
BRP1602: Evaluation of Technical and Logistical Feasibility to Measure Lung Permeability
RAI Services Company
NCT06105424
Sensory Perception of Sweet Flavors in E-Cigarette
Oregon State University
NCT03332953
E-cigarette Nicotine Pharmacokinetic Study
British American Tobacco (Investments) Limited
NCT03178981
E-cigarettes for Harm Reduction in Adults With Asthma
Brown University
NCT05278065
Galantamine Effects on Nicotine Responses in Smokers
Yale University
NCT01417429
A Usability Study of a Smoking Cessation Decision Aid in People With a Recent First Episode of Psychosis
Northwell Health
NCT01399112
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 9 |
| Phase 2 | 13 |
| Phase 3 | 4 |
| Phase 4 | 9 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking page
124 registered trials, 27 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 27 Smoking trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- RAI Services Company sponsors the most Smoking trials on record, review their full trial history before evaluating a specific study. See RAI Services Company's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking condition card totals 124 registered trials; most-linked intervention Placebo; top US site state New York. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.