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Smoking Cessation: full-pipeline trial registry
57 of 189 indexed Smoking Cessation trials are currently recruiting.
Corpus placement: #57 of 28,707 conditions by registered trial count.
189 US clinical trials · 57 currently recruiting · #57 of 28,707 conditions by registered trial count
Smoking Cessation: 189 US clinical trials tracked, 57 recruiting.
Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.
Enrollment posture brief
Registry condition smoking-cessation
OPEN 57 | RECR 30% | LATE 33 | EARLY 30 | RANK #57 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Heart Diseases (30% recruiting · 86 trials)
Smoking Cessation lists 57 open slots (30% of 189 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking Cessation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking Cessation is recruiting below its size-band peers.
57 of 189 indexed trials (30.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking Cessation trials is spread across many organizations.
University of California, San Francisco accounts for 10 of 189 trials (5.3%). 84 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking Cessation enrolment sits around 200 participants.
Median target enrolment is 200 among the 189 trials that report a genuine target (sentinel values excluded). 71 of those (37.6%) plan for fewer than 100 participants.
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Smoking Cessation research is mostly interventional.
181 interventional and 8 observational studies make up this index (95.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
189 total, page 3 of 4
Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).
Pfizer
NCT00285012
Pharmacoeconomic Assessment in Nabi-4514 and Nabi-4515 Phase 3 Studies
Nabi Biopharmaceuticals
NCT01178346
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
Pfizer
NCT01244061
Quit Smoking Program for Lung Cancer Patients' Families (The Family Ties Project)
Duke University
NCT00345891
Promoting Smoking Cessation in Carpenters
Washington University School of Medicine
NCT01878214
Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants
NYU Langone Health
NCT03187730
Latinos Kick Buts: Mobile Engagement and Cessation Support for Latino Smokers
University of Rochester
NCT05278481
Increasing Physical Activity as Part of a Smoking Cessation Program
National Heart, Lung, and Blood Institute (NHLBI)
NCT00403312
Individualizing Pharmacotherapy for African American Smokers
University of Kansas Medical Center
NCT03897439
Cigarette Pack Inserts for Smoking Cessation
University of South Carolina
NCT04075682
Patient Navigation and Financial Incentives to Promote Smoking Cessation
Boston Medical Center
NCT02351609
Efficacy of Naltrexone in Women's Smoking Cessation
University of Chicago
NCT00271024
Nicotine Mouth Film for Craving Relief.
GlaxoSmithKline
NCT01702532
Varenicline OTC Trial on Efficacy and Safety
Arizona State University
NCT03557294
Efficacy of Two Novel Behavioral Post-cessation Weight Gain Interventions
University of Tennessee
NCT03156660
Integrating Tobacco Treatment Into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial
Massachusetts General Hospital
NCT01871506
A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation
Nabi Biopharmaceuticals
NCT01304810
Smoking Reduction and Cessation Interventions for Chinese
University of California, San Francisco
NCT00714532
Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain
Abramson Cancer Center at Penn Medicine
NCT02906787
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
University of Kansas Medical Center
NCT02244918
Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer (PIP)
Yale University
NCT02658032
Cognition and Smoking Relapse (HCS)
University of Pennsylvania
NCT03169101
Pager-Assisted Smoking Cessation Treatment
University of California, San Francisco
NCT01207310
P60 Program Project Grant-Outreach for Smoke-Free Homes
University of Minnesota
NCT01574560
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
Smoking Cessation Via Text Messaging: Feasibility Testing of Stop My Smoking USA
Center for Innovative Public Health Research
NCT01516632
Smoking Cessation After Hospitalization for a Cardiopulmonary Illness
North Shore Medical Center
NCT01791803
Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
H. Lee Moffitt Cancer Center and Research Institute
NCT02796391
Examining Outcome Expectancies and Behavioral Reinforcers Among Young Adult Smokers
American University
NCT04383782
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
WeChat Quit Coach Pilot Study
NYU Langone Health
NCT05130788
Smoking Cessation in NYC
Temple University
NCT04489524
Phone-Based Postpartum Continuing Care for Smoking Cessation
Battelle Memorial Institute
NCT01684592
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
Joseph Valentino, MD
NCT04634071
Auriculotherapy for Smoking Cessation: Pilot
US Department of Veterans Affairs
NCT01189110
Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults
University of Minnesota
NCT01497158
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
University of Arizona
NCT02968381
Guanfacine Clinical Trial for Smoking Cessation
Yale University
NCT02051309
Shared Decision Making in Rural Primary Care Lung Cancer Screening and Smoking Cessation
University of Colorado, Denver
NCT04897568
Provoked Craving Relief Study by NRT
GlaxoSmithKline
NCT01476202
Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence
National Institute on Drug Abuse (NIDA)
NCT01034384
Development and Pilot Testing of a Multimodal Web-based Program to Address Heavy Drinking During Smoking Cessation
Brown University
NCT03068611
Relapse Prevention With Varenicline
Johns Hopkins University
NCT00944554
Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV
Butler Hospital
NCT01886924
Hollings Cancer Center Varenicline Sampling Study
Medical University of South Carolina
NCT03742154
Neuroimaging Studies of Smoking and Treatment
University of Kansas Medical Center
NCT03085602
Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation
Lindner Center of HOPE
NCT00280839
Contingency Management for Smoking Cessation
University of California, San Francisco
NCT04982952
Mechanisms of Mindfulness for Smoking Cessation
Brown University
NCT02943499
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Virginia Commonwealth University
NCT00390559
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking Cessation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking Cessation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking Cessation page
189 registered trials, 57 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 57 Smoking Cessation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of California, San Francisco sponsors the most Smoking Cessation trials on record, review their full trial history before evaluating a specific study. See University of California, San Francisco's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking Cessation condition card totals 189 registered trials; most-linked intervention Varenicline; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.