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Smoking Cessation clinical trials
57 of 189 indexed Smoking Cessation trials are currently recruiting.
189 US clinical trials · 57 currently recruiting
Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.
The research picture
Smoking Cessation has 189 registered US clinical trials, 57 of them open to new participants right now, about 30% of the total.
- 57
- recruiting participants now
- 30%
- of trials open to enrollment
- 33
- in Phase 3–4 (later-stage)
- 10
- top sponsor: University of California, San Francisco
Active & Recent Trials
189 total, page 3 of 4
Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).
Pfizer
NCT00285012
Pharmacoeconomic Assessment in Nabi-4514 and Nabi-4515 Phase 3 Studies
Nabi Biopharmaceuticals
NCT01178346
A Multi-National Study To Assess How Effective And Safe The Smoking Cessation Medicine Varenicline Is In Smokers Who Have Already Tried Varenicline In The Past As A Prescription Medicine From Their Usual Healthcare Provider
Pfizer
NCT01244061
Quit Smoking Program for Lung Cancer Patients' Families (The Family Ties Project)
Duke University
NCT00345891
Promoting Smoking Cessation in Carpenters
Washington University School of Medicine
NCT01878214
Integrating Financial Management Counseling and Smoking Cessation Counseling to Reduce Health and Economic Disparities in Low-Income Immigrants
NYU Langone Health
NCT03187730
Latinos Kick Buts: Mobile Engagement and Cessation Support for Latino Smokers
University of Rochester
NCT05278481
Increasing Physical Activity as Part of a Smoking Cessation Program
National Heart, Lung, and Blood Institute (NHLBI)
NCT00403312
Individualizing Pharmacotherapy for African American Smokers
University of Kansas Medical Center
NCT03897439
Cigarette Pack Inserts for Smoking Cessation
University of South Carolina
NCT04075682
Patient Navigation and Financial Incentives to Promote Smoking Cessation
Boston Medical Center
NCT02351609
Efficacy of Naltrexone in Women's Smoking Cessation
University of Chicago
NCT00271024
Nicotine Mouth Film for Craving Relief.
GlaxoSmithKline
NCT01702532
Varenicline OTC Trial on Efficacy and Safety
Arizona State University
NCT03557294
Efficacy of Two Novel Behavioral Post-cessation Weight Gain Interventions
University of Tennessee
NCT03156660
Integrating Tobacco Treatment Into Cancer Care: A Randomized Controlled Comparative Effectiveness Trial
Massachusetts General Hospital
NCT01871506
A Follow-up Study to Assess Long-term Immunogenicity and Safety of NicVAX/Placebo as an Aid to Smoking Cessation
Nabi Biopharmaceuticals
NCT01304810
Smoking Reduction and Cessation Interventions for Chinese
University of California, San Francisco
NCT00714532
Behavioral Activation for Smoking Cessation and the Prevention of Post-Cessation Weight Gain
Abramson Cancer Center at Penn Medicine
NCT02906787
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
University of Kansas Medical Center
NCT02244918
Personalized Intervention Program: Tobacco Treatment for Patients at Risk for Lung Cancer (PIP)
Yale University
NCT02658032
Cognition and Smoking Relapse (HCS)
University of Pennsylvania
NCT03169101
Pager-Assisted Smoking Cessation Treatment
University of California, San Francisco
NCT01207310
P60 Program Project Grant-Outreach for Smoke-Free Homes
University of Minnesota
NCT01574560
A Facebook Intervention for Young Sexual and Gender Minority Smokers
University of California, San Francisco
NCT03259360
Smoking Cessation Via Text Messaging: Feasibility Testing of Stop My Smoking USA
Center for Innovative Public Health Research
NCT01516632
Smoking Cessation After Hospitalization for a Cardiopulmonary Illness
North Shore Medical Center
NCT01791803
Facilitating Smoking Cessation With Reduced Nicotine Cigarettes
H. Lee Moffitt Cancer Center and Research Institute
NCT02796391
Examining Outcome Expectancies and Behavioral Reinforcers Among Young Adult Smokers
American University
NCT04383782
Innovative Digital Therapeutic for Smoking Cessation
My Digital Study
NCT03694327
WeChat Quit Coach Pilot Study
NYU Langone Health
NCT05130788
Smoking Cessation in NYC
Temple University
NCT04489524
Phone-Based Postpartum Continuing Care for Smoking Cessation
Battelle Memorial Institute
NCT01684592
Tobacco Treatment Optimization and Preferences During Concurrent Cancer Treatment
Joseph Valentino, MD
NCT04634071
Auriculotherapy for Smoking Cessation: Pilot
US Department of Veterans Affairs
NCT01189110
Promoting Home Smoking Restrictions: Biomarker Feedback to Smoking and Non-Smoking Adults
University of Minnesota
NCT01497158
A Guided Imagery Tobacco Cessation Intervention Delivered by a Quit Line and Website
University of Arizona
NCT02968381
Guanfacine Clinical Trial for Smoking Cessation
Yale University
NCT02051309
Shared Decision Making in Rural Primary Care Lung Cancer Screening and Smoking Cessation
University of Colorado, Denver
NCT04897568
Provoked Craving Relief Study by NRT
GlaxoSmithKline
NCT01476202
Physiological, Cognitive and Cerebral Activity Changes as a Function of Cigarette Smoking (With or Without Nicotine) and Tobacco Abstinence
National Institute on Drug Abuse (NIDA)
NCT01034384
Development and Pilot Testing of a Multimodal Web-based Program to Address Heavy Drinking During Smoking Cessation
Brown University
NCT03068611
Relapse Prevention With Varenicline
Johns Hopkins University
NCT00944554
Computer MI for Tobacco Quitline Engagement in Smokers Living With HIV
Butler Hospital
NCT01886924
Hollings Cancer Center Varenicline Sampling Study
Medical University of South Carolina
NCT03742154
Neuroimaging Studies of Smoking and Treatment
University of Kansas Medical Center
NCT03085602
Safety and Efficacy Study of Topiramate to Aid in Smoking Cessation
Lindner Center of HOPE
NCT00280839
Contingency Management for Smoking Cessation
University of California, San Francisco
NCT04982952
Mechanisms of Mindfulness for Smoking Cessation
Brown University
NCT02943499
Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3
Virginia Commonwealth University
NCT00390559
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Smoking Cessation Trial Landscape
189 indexed Smoking Cessation studies · 57 recruiting (30%).
Phase mix: 33 late (III/IV) vs 30 early (I/II).
Top sponsor: University of California, San Francisco (10 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Smoking Cessation?
PlainTrial tracks 189 US clinical trials for Smoking Cessation, of which 57 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Smoking Cessation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.