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Smoking Cessation: full-pipeline trial registry
57 of 189 indexed Smoking Cessation trials are currently recruiting.
Corpus placement: #57 of 28,707 conditions by registered trial count.
189 US clinical trials · 57 currently recruiting · #57 of 28,707 conditions by registered trial count
Smoking Cessation: 189 US clinical trials tracked, 57 recruiting.
Smoking Cessation is the subject of 189 registered US clinical trials on ClinicalTrials.gov, 57 of them currently open to new participants. 33 are in Phase 3-4 (later-stage) and 30 in Phase 1-2 (earlier-stage). The most active sponsor is University of California, San Francisco, running 10 of these trials.
Enrollment posture brief
Registry condition smoking-cessation
OPEN 57 | RECR 30% | LATE 33 | EARLY 30 | RANK #57 | SPON 10
Volume-matched condition peers
Nearest open-share peer: Heart Diseases (30% recruiting · 86 trials)
Smoking Cessation lists 57 open slots (30% of 189 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Smoking Cessation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Smoking Cessation is recruiting below its size-band peers.
57 of 189 indexed trials (30.2%) are open to enrollment, against a 37.1% average across 139 conditions with 100+ trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Smoking Cessation trials is spread across many organizations.
University of California, San Francisco accounts for 10 of 189 trials (5.3%). 84 distinct sponsors appear on at least one study for this condition label.
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Typical Smoking Cessation enrolment sits around 200 participants.
Median target enrolment is 200 among the 189 trials that report a genuine target (sentinel values excluded). 71 of those (37.6%) plan for fewer than 100 participants.
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Smoking Cessation research is mostly interventional.
181 interventional and 8 observational studies make up this index (95.8% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
189 total, page 2 of 4
Deep rTMS Modulating Insula Synaptic Density and Smoking Behavior in Schizophrenia
Stony Brook University
NCT05724810
Preliminary Effectiveness of Enhanced Text Message + Incentives
University of Kansas Medical Center
NCT07420621
A Culturally Tailored Smartphone Application for African American Smokers
University of Oklahoma
NCT05188287
Trauma-Informed Care for Smoking Cessation for Pregnancy
University of California, San Francisco
NCT07129590
Contingency Management to Promote Smoking Cessation
University of Kansas Medical Center
NCT06456242
Development of a MHBC Intervention for Weight Loss and Smoking Cessation for Pre-Bariatric Surgery Patients
Yale University
NCT07224087
A Study Evaluating the Use of an Indoor Air Quality Monitor to Promote a Smoke-free Home
Memorial Sloan Kettering Cancer Center
NCT06693700
Evaluation of an "Opt-Out" Inpatient Smoking Cessation Service on Smoking Behavior Study #1
Medical University of South Carolina
NCT04827914
A Randomized Clinical Trial Assessing Smoking Cessation Interventions In Dental Clinic Smokers
Memorial Sloan Kettering Cancer Center
NCT00591175
Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites
Memorial Sloan Kettering Cancer Center
NCT03315910
A Pragmatic Trial of Chronic Disease Approaches to Ameliorate Tobacco Related Cardiovascular Disease Health Disparities
University of Minnesota
NCT05671380
Automated Video-Assisted Smoking Treatment for People Living With HIV
H. Lee Moffitt Cancer Center and Research Institute
NCT05014282
Smoking Cessation Intervention During Low Dose CT (LDCT) Screening for Lung Cancer
M.D. Anderson Cancer Center
NCT03059940
Mobile Contingency Management for Smoking Cessation
University of Oklahoma
NCT04881630
Partnering With Food Bank to Provide Tobacco Treatment to Underserved Smokers
H. Lee Moffitt Cancer Center and Research Institute
NCT05004662
Telephone All Nations Breath of Life
Lehigh University
NCT04764175
VR Smoking Cessation During a Dental Hygiene Visit
Boston University
NCT04524533
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)
H. Lee Moffitt Cancer Center and Research Institute
NCT05645146
Construal Level as a Novel Pathway for Affect Regulation and Cancer Control
University of Oregon
NCT04620915
Implementation of a System-level Tobacco Treatment Intervention
Dana-Farber Cancer Institute
NCT02816697
Improving the Reach & Effectiveness of Smoking Cessation Services Targeted to Veterans Living With HIV
Seattle Institute for Biomedical and Clinical Research
NCT04505371
Digitally Enhanced Smoking Cessation for High Risk Smokers
Dana-Farber Cancer Institute
NCT04691297
Smoking Cessation Treatment for Head & Neck Cancer Patients
M.D. Anderson Cancer Center
NCT01098955
Forward to Quit: A Person-centered Mobile Technology Intervention for Smoking Cessation Among Transgender Adults
University of Colorado, Denver
NCT07181551
Acceptability of Mobile Applications (Apps) to Enhance Smoking Cessation in a Clinical Tobacco Treatment Program - A Pilot Study
M.D. Anderson Cancer Center
NCT05038852
Randomized Clinical Trial to Reduce Harm From Tobacco
University of Pennsylvania
NCT02328794
Young Adult Smoker's Treatment Demand
University of Illinois at Chicago
NCT01569529
Latinos Kick Buts: Mobile Engagement and Cessation Support for Latinos Who Smoke
University of Rochester
NCT05722132
A 52-Week Multicenter Study Evaluating the Safety and Efficacy of Varenicline for the Maintenance of Smoking Cessation
Pfizer
NCT00143286
Helping Poor Smokers Quit
Washington University School of Medicine
NCT03194958
Facilitating Implementation of the PHS Smoking Cessation Guidelines - RESET
US Department of Veterans Affairs
NCT00057070
Dissemination of Tobacco Tactics for Hospitalized Smokers
University of Michigan
NCT01309217
Spanish-Language Smoking Cessation Trial
H. Lee Moffitt Cancer Center and Research Institute
NCT02945787
Evaluating a Telephone-Based Smoking Cessation Program Among People in the Military (The AFIII Study)
University of Tennessee
NCT00632411
Expert System and Family Assisted Interventions for Chinese Smokers
University of California, San Francisco
NCT00714467
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
Medical University of South Carolina
NCT01509586
A Comparative Effectiveness & Long Term Health Study in Wisconsin Smokers
University of Wisconsin, Madison
NCT01553084
Improving the Population-Wide Effectiveness of U.S. Tobacco Cessation Quitlines
University of Wisconsin, Madison
NCT01087905
Twitter-enabled Mobile Messaging for Smoking Relapse Prevention (Tweet2Quit)
University of California, Irvine
NCT02823028
Computer-Facilitated 5A's for Smoking Cessation in Primary Care
University of California, San Francisco
NCT02046408
Genetically Informed Smoking Cessation Trial
Washington University School of Medicine
NCT02351167
Disease Management for Smoking Cessation
University of Kansas Medical Center
NCT00440115
An Open Label Study That Compares Varenicline to Transdermal Nicotine Patch for Smoking Cessation
Pfizer
NCT00143325
Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking
Pfizer
NCT00282984
Randomized Study Comparing the Efficacy and Safety of Varenicline Tartrate to Placebo in Smoking Cessation When Subjects Are Allowed to Set Their Own Quit Date
Pfizer
NCT00691483
Pharmacogenetics, Emotional Reactivity and Smoking
M.D. Anderson Cancer Center
NCT00507728
Combining Varenicline and Bupropion for Smoking Cessation
M.D. Anderson Cancer Center
NCT00943618
Connect to Quit for Smoking
University of Pittsburgh
NCT01299896
Evaluation of a Tailored Smoking Cessation Treatment Algorithm Based on Initial Treatment Response and Genotype
Duke University
NCT00894166
Identifying Treatments to Motivate Smokers to Quit
University of Wisconsin, Madison
NCT01122238
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 15 |
| Phase 2 | 15 |
| Phase 3 | 14 |
| Phase 4 | 19 |
Top Sponsors
Named interventions
Most-linked intervention names on Smoking Cessation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Smoking Cessation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Smoking Cessation page
189 registered trials, 57 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 57 Smoking Cessation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- University of California, San Francisco sponsors the most Smoking Cessation trials on record, review their full trial history before evaluating a specific study. See University of California, San Francisco's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Smoking Cessation condition card totals 189 registered trials; most-linked intervention Varenicline; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.